Results 61 to 70 of about 523,256 (269)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Methodological Problems and Strategic Goals of the Work on Creation of the Theory and Technology of New Generation Intelligent Computer Systems

Цифровая трансформация
The main methodological problems and strategic goals of work on creating the theory and technology of intelligent computer systems of a new generation are considered.
V. V. Golenkov, N. A. Guliakina, D. V. Shunkevich   +2 more
doaj   +1 more source

A survey on the studies employing machine learning (ML) for enhancing artificial bee colony (ABC) optimization algorithm

Cogent Engineering, 2020
Nature-inspired optimization (NIO) algorithms have gained quite a popularity among the researchers due to their good performance on difficult optimization problems.
Dervis Karaboga, Bahriye Akay, Nurhan Karaboga   +2 more
doaj   +1 more source

Hunting behavior and feeding ecology of Mojave rattlesnakes (Crotalus scutulatus), prairie rattlesnakes (Crotalus viridis), and their hybrids in southwestern New Mexico

Ecology and Evolution, 2023
Predators must contend with numerous challenges to successfully find and subjugate prey. Complex traits related to hunting are partially controlled by a large number of co‐evolved genes, which may be disrupted in hybrids.
Dylan W. Maag, Yannick Z. Francioli, Noelle Shaw, Ashana Y. Soni, Todd A. Castoe, Gordon W. Schuett, Rulon W. Clark   +6 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Membrana metropolitana costera. Estrategias para proyectar una ciudad híbrida

Area
Muchas de nuestras ciudades latinoamericanas se caracterizan por ser espacios fragmentados en continua expansión, no sólo en términos urbanos, sino también en lo social, económico y político.
Luisa Acosta Scandela, Juan Carlos Arismendi, Jesús Cabrera, Stephany Sánchez, Nelymar Vera   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Anthropogenic Hybridization Contributes to the Naturalization of Introduced Domestic Mallards (Anas platyrhynchos) at the Expense of Native New Zealand Gray Ducks (A. s. superciliosa)

Ecology and Evolution
Anthropogenically mediated hybridization can lead to several outcomes, with the most severe being hybrid swarms and the genetic extirpation of local populations.
Joshua I. Brown, Jennifer L. Sheppard, Jonathon Mohl, Irene E. Engilis, Andrew Engilis Jr., Philip Lavretsky   +5 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source