Results 71 to 80 of about 1,066,085 (279)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Pre‐ and Post‐Copulatory Sexual Traits Influence Male Fitness Across a Mosaic Hybrid Zone

Ecology and Evolution
Primary and secondary male sexual traits can influence the interspecific interactions of hybridizing populations, yielding fitness consequences and either promoting or restricting gene flow.
Logan M. Maxwell, Jennifer Walsh, Brian J. Olsen, Adrienne I. Kovach   +3 more
doaj   +1 more source

Fluorescent Calcium Imaging and Subsequent In Situ Hybridization for Neuronal Precursor Characterization in Xenopus laevis [PDF]

, 2020
Spontaneous intracellular calcium activity can be observed in a variety of cell types and is proposed to play critical roles in a variety of physiological processes.
Ablondi, Eileen F., Halleran, Andrew D., Kemper, Peter, Marken, John P., Paudel, Sudip, Rahman, Atiqur, Saha, Margaret S., Sehdev, Morgan   +7 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Methodological Problems and Strategic Goals of the Work on Creation of the Theory and Technology of New Generation Intelligent Computer Systems

Цифровая трансформация
The main methodological problems and strategic goals of work on creating the theory and technology of intelligent computer systems of a new generation are considered.
V. V. Golenkov, N. A. Guliakina, D. V. Shunkevich   +2 more
doaj   +1 more source

A survey on the studies employing machine learning (ML) for enhancing artificial bee colony (ABC) optimization algorithm

Cogent Engineering, 2020
Nature-inspired optimization (NIO) algorithms have gained quite a popularity among the researchers due to their good performance on difficult optimization problems.
Dervis Karaboga, Bahriye Akay, Nurhan Karaboga   +2 more
doaj   +1 more source

Hunting behavior and feeding ecology of Mojave rattlesnakes (Crotalus scutulatus), prairie rattlesnakes (Crotalus viridis), and their hybrids in southwestern New Mexico

Ecology and Evolution, 2023
Predators must contend with numerous challenges to successfully find and subjugate prey. Complex traits related to hunting are partially controlled by a large number of co‐evolved genes, which may be disrupted in hybrids.
Dylan W. Maag, Yannick Z. Francioli, Noelle Shaw, Ashana Y. Soni, Todd A. Castoe, Gordon W. Schuett, Rulon W. Clark   +6 more
doaj   +1 more source

Thermodynamic behavior of short oligonucleotides in microarray hybridizations can be described using Gibbs free energy in a nearest-neighbor model

, 2007
While designing oligonucleotide-based microarrays, cross-hybridization between surface-bound oligos and non-intended labeled targets is probably the most difficult parameter to predict. Although literature describes rules-of-thumb concerning oligo length,
Carlon, E., De Vuyst, L., Van Hummelen, P., Weckx, S.   +3 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source