Results 61 to 70 of about 9,447 (241)

Potential PET Ligands for Imaging of Cerebral VPAC and PAC Receptors: Are Non-Peptide Small Molecules Superior to Peptide Compounds? [PDF]

, 2015
Pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) have been known for decades to mediate neuroendocrine and vasodilative actions via G-protein-coupled receptors of Class B.
Pissarek, Margit
core   +1 more source

Carrier‐free self‐assembled nanomedicine for combination‐therapy of acute myeloid leukemia

BMEMat, EarlyView.
CPDS combines drugs with three different mechanisms of action to achieve a multi‐mechanism combination therapy for AML by directly killing tumor cells and activating anti‐tumor immunity. Abstract As the main acute myeloid leukemia (AML) clinical treatment, the chemotherapy alone cannot meet the clinical therapeutic needs due to the high heterogeneity ...
Meihong Chai, Rui Zhang, Haiyin Yang, Jiyue Xing, Tianyuan Hu, Mengxi Zhu, Rui Li, Xiaoli Chen, Beibei Zhao, Yang Lan, Stefan Barth, Yuanyu Huang, Li Zhang, Mengjie Zhang, Huining He   +14 more
wiley   +1 more source

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

Synthesis and In Vitro Anticancer Activity of Pyrrolidone Derivatives Bearing 3,4,5-Trimethoxyphenyl Moiety as a Promising Anticancer Scaffold

Applied Sciences
A series of 5-oxo-1-(3,4,5-trimethoxyphenyl)pyrrolidine-3-carboxylic acid derivatives–hydrazones, N-ethylhydrazones, pyrrole, pyrazole, oxadiazole, and triazole were synthesized and evaluated for their anticancer activity using human A549 pulmonary ...
Povilas Kavaliauskas, Birutė Sapijanskaitė-Banevič, Birutė Grybaitė, Eglė Mickevičiūtė, Kazimieras Anusevičius, Andrew Garcia, Ethan Naing, Rūta Petraitienė, Vidmantas Petraitis, Ramunė Grigalevičiūtė, Vytautas Mickevičius   +10 more
doaj   +1 more source

Oxidations of Benzhydrazide and Phenylacetic Hydrazide by Hexachloroiridate(IV): Reaction Mechanism and Structure–Reactivity Relationship

Molecules, 2020
Benz(o)hydrazide (BH) is the basic aryl hydrazide; aryl hydrazides have been pursued in the course of drug discovery. Oxidations of BH and phenylacetic hydrazide (PAH) by hexachloroiridate(IV) ([IrCl6]2−) were investigated by use of stopped-flow ...
Xiaolai Zhang
doaj   +1 more source

Bivalent Enzyme Inhibitors Discovered Using Dynamic Covalent Chemistry [PDF]

, 2012
A bivalent dynamic covalent chemistry (DCC) system has been designed to selectively target members of the homodimeric glutathione-S-transferase (GST) enzyme family.
Ang, Appiah-Opong, Beeren, Beeren, Beeren, Bhat, Bhat, Blanden, Bunyapaiboonsri, Bunyapaiboonsri, Carroll, Cheng, Cho, Corbett, Corbett, Corbett, Cordes, Cousins, Deng, Dirksen, Dorion, Erlanson, Federici, Furlan, Gromova, Habig, Hayes, Hochgürtel, Huc, Jao, Li, Lins, Liu, Liénard, Liénard, Lyon, Maeda, Mahajan, Mannervik, McIlwain, Oakley, Oakley, Oakley, Patskovsky, Poulsen, Poulsen, Ralat, Ramström, Ramström, Roberts, Romieu, Ryoo, Sampsonas, Severin, Sheehan, Shi, Simpson, Simpson, Son, Townsend, Tsuboi, Woon, Xue, Zameo, Zameo   +64 more
core   +1 more source

Self‐Immolative Gels: Programmable Degradation Using Self‐Immolative Linkers and Polymers

Chemistry – A European Journal, EarlyView.
Self‐immolative linkers and polymers undergo bond‐cleaving reaction cascades in response to specific stimuli. Their incorporation into gels can be harnessed to release cargo, induce property changes, or trigger degradation in a highly controlled manner. These functions can be employed in applications such as sensing and drug delivery.
Chuanfeng Li, Elizabeth R. Gillies
wiley   +1 more source

Synthesis and Biological Evaluation of Some Dipeptide Derivatives and Their Heterocyclic Compounds

Science Journal of University of Zakho, 2015
The protected dipeptide esters (3a-e, 4a-l) is prepared by the reaction of compounds (1a-e, 2a-d) with dicyclohexylcarbodiamide (as coupling reagent) and amino acid esters .Thereafter hydrazides (5a-e, 6a-j) are obtained by the reaction of corresponding ...
Huda A. Basheer, Sabir A. Sabir, Aveen A. Ibrahiem   +2 more
doaj  

Biocompatibility and tissue regenerating capacity of crosslinked dermal sheep collagen [PDF]

, 1994
The biocompatibility and tissue regenerating capacity of four crosslinked dermal sheep collagens (DSC) was studied. In vitro, the four DSC versions were found to be noncytotoxic or very low in cytoxicity.
Anselme, Bannenberg, Berry, Bessis, Blaauw, Damink, Damink, Damink, Damink, Damink, Damink, Damink, Flory, Galli, Gorham, Levy, Nedkov, Petite, Schoen, Speer, Srivastava, Steinberg, van der Laan, van der Wal, van Gulik, van Luyn, van Luyn, van Luyn, van Luyn, van Luyn, van Wachem, van Wachem, van Wachem, van Wachem, Wasserman, Weiss, Werkmeister   +36 more
core   +2 more sources

Ultra‐High Strength and Environmentally Stable Fluorinated Solid‐State Ion‐Conductive Elastomers with Folding‐Paper‐Structured Triboelectric Nanogenerators for Wave Energy Harvesting

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
In this work, a polyurethane‐based fluorinated SICEs with excellent mechanical properties (7.35 MPa and 61.4 MJ m−3), conductivity (4.2 × 10−4 S cm−1), and harsh environmental resistance were prepared by a “three birds with one stone” strategy that combines multiple interactions with fluorine effects. The paper‐folding TENG is capable of harvesting not
Zequan Li, Fangyan Ou, Wei Tang, Fuqi Wang, Zhichao Zhang, Ting Xie, Chuang Ning, Wenyu Pan, Wei Gao, Shuangliang Zhao   +9 more
wiley   +1 more source