Results 61 to 70 of about 3,055 (201)

Synthesis and Biological Evaluation of Some Dipeptide Derivatives and Their Heterocyclic Compounds

Science Journal of University of Zakho, 2015
The protected dipeptide esters (3a-e, 4a-l) is prepared by the reaction of compounds (1a-e, 2a-d) with dicyclohexylcarbodiamide (as coupling reagent) and amino acid esters .Thereafter hydrazides (5a-e, 6a-j) are obtained by the reaction of corresponding ...
Huda A. Basheer, Sabir A. Sabir, Aveen A. Ibrahiem   +2 more
doaj  

New Hydrazone Derivatives Featuring Isatin and Piperazine Moieties: Synthesis, Cytotoxicity Evaluation, and Molecular Modeling Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT In this study, ten novel compounds (IPH1–IPH10) were designed by integrating three pharmacophores (isatin, piperazine, and hydrazone) commonly found in the molecular structures of anticancer agents. The target molecules were obtained by the reaction of in‐house prepared 4‐(4‐(pyridin/pyrimidin‐2‐yl)piperazin‐1‐yl)benzohydrazide with various ...
Semiha Köprü, Münevver Baran, Miyase Gözde Gündüz, Şengül Dilem Doğan   +3 more
wiley   +1 more source

Poly(O‐Propargyl‐N‐Amino Carbamate), a Reactive Polymer to Underpin Biomedical Applications of Poly(acetylene)s

Macromolecular Rapid Communications, EarlyView.
We report here a new methodology to prepare functional poly(acetylene)s under aqueous conditions. This methodology is underpinned by poly(O‐propargyl‐N‐amino carbamate) (P1), a reactive poly(acetylene) carrying acyl hydrazines. Thus, P1 reacts with aldehydes to give functional poly(acetylene)s, including cationic, hydrophobic, and sugar‐loaded poly ...
Tom Leigh, Greta Bellio, Daniel Crisan, Amit Deb, Alba Ramil‐Bouzas, Andrey Romanyuk, Ivan Torreiro‐Leon, Ana Rey‐Rico, Paco Fernandez‐Trillo   +8 more
wiley   +1 more source

Aliphatic Poly(Carbonate)s with Acid Responsive Release Mechanisms for Micellar Anti‐Tumor Drug Delivery

Macromolecular Rapid Communications, EarlyView.
Micellar systems based on biodegradable aliphatic polycarbonates and acid‐responsive triggers enhance drug solubility, stability, and tumor‐selective release. This review covers micelles with acid‐cleavable drug linkages and those that disassemble via acid‐sensitive functionalities.
Adrian V. Hauck, Lutz Nuhn
wiley   +1 more source

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

Journal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.
This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá, Ladislav Androvič, Marcela Filipová, Michal Pechar, Richard Laga   +4 more
wiley   +1 more source

Hydrazinolysis of lipids and analysis of their constituent fatty acids

Journal of Lipid Research, 1983
Treatment of O-acyl lipids with hydrazine degrades them to hydrazides of the constituent fatty acids. These hydrazides react with acetone to yield less polar and more volatile N'-isopropylidenealkanohydrazides, R-CO-NH-N = C(CH3)2, which strongly absorb ...
V P Agrawal
doaj   +1 more source

Enhancing High‐Humidity Stability of CsPbI3 Perovskite Solar Cells Through Strong Bidentate Ligand Coordination

Small, EarlyView.
Inorganic CsPbI3 perovskite solar cells suffer from rapid phase degradation under high humidity. We show that bidentate coordination using 2‐amino‐6‐methoxybenzothiazole (AMBT) provides significantly stronger defect passivation than monodentate p‐toluenesulfonyl hydrazide, achieving a binding energy of −1.91 eV with the perovskite surface.
Karthikeyan Embrose, Thangaraji Vasudevan, Lung‐Chien Chen   +2 more
wiley   +1 more source

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +2 more sources

Recent Advances in Photocatalyst‐Driven Protein Labeling and Proximity Mapping

The Chemical Record, EarlyView.
Photocatalyst‐driven protein labeling and proximity mapping have rapidly advanced as powerful strategies for spatiotemporal control in complex biological environments. This review integrates recent developments across single‐electron transfer and energy transfer‐based mechanisms and highlights how catalyst design, reactive intermediates, and diffusion ...
Shinichi Sato, Kazuki Miura, Juki Nakao, Hiroyuki Nakamura   +3 more
wiley   +1 more source

New 4-(Morpholin-4-Yl)-3-Nitrobenzhydrazide Based Scaffold: Synthesis, Structural Insights, and Biological Evaluation

Molecules
The search for new antimicrobial agents is one of the major challenges in contemporary medicinal chemistry due to the global issue of increasing drug resistance.
Michał Janowski, Sara Janowska, Sylwia Andrzejczuk, Urszula Kosikowska, Radomir Jasiński, Barbara Mirosław, Marcin Feldo, Monika Wujec, Oleg M. Demchuk   +8 more
doaj   +1 more source