Results 191 to 200 of about 13,633 (275)

Novel hydrazine molecules as tools to understand the flexibility of vascular adhesion protein-1 ligand-binding site: toward more selective inhibitors [PDF]

, 2011
Fülöp Ferenc, Lázár László, Nurminen Elisa M., Pentikainen Olli T., Pentikainen Ulla, Pihlavisto Marjo   +5 more
core   +1 more source

Synthesis, Characterization, and Cytotoxic Activity Properties of Some Novel Purine Derivatives

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 5, May 2026.
Nine novel purine derivatives were successfully synthesized and its cytotoxic activities were evaluated against HepG2 and MDA‐MB‐231 cancer cell lines. ABSTRACT This study reports the synthesis of nine new compounds with purine scaffolds. It thoroughly analyzes them using a variety of spectroscopic methods, including high‐resolution mass spectrometry ...
Nurdan Akdoğan, Ayşenur Işgüzar, Senem Akkoc, Muhammed Tilahun Muhammed, Sadeq K. Alhag, Laila A. Al‐Shuraym, Ali Dişli   +6 more
wiley   +1 more source

Photo-induced selective N-N bond construction via harnessing nitrene release and transfer. [PDF]

Nat Commun
Yu M, Feng J, Wang X, Xiang X, Hu Y, Wang ZH, Xu ZF, Jie J, Su H, Tang H, Li CY.   +10 more
europepmc   +1 more source

Discovery of 4‐Quinazolinone‐Containing Phenylalanine Derivatives as Potent, Resistant‐Tolerant HIV Capsid Inhibitors

MedComm, Volume 7, Issue 5, May 2026.
Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Xujie Zhang, Lin Sun, Laura Walsham, Yuexi Ma, Dang Ding, Mei Wang, Fabao Zhao, Jian Zhang, Zhao Wang, Shujing Xu, Xiangyi Jiang, Yang Zhou, Erik De Clercq, Christophe Pannecouque, Chin‐Ho Chen, David C. Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan   +18 more
wiley   +1 more source

High-pressure activation for the solvent- and catalyst-free syntheses of heterocycles, pharmaceuticals and esters. [PDF]

Beilstein J Org Chem
Plasse K, Wright V, Xie G, Vlocskó RB, Lazarev A, Török B.   +5 more
europepmc   +1 more source

Fluctuating β‐Sheet Secondary Structure in DS119 Explains the Small Effects of Backbone N‐Amination on Thermal Stability

Journal of Peptide Science, Volume 32, Issue 5, May 2026.
Residues with backbone N‐amination have been introduced into a region of parallel β‐sheet secondary structure. Contrary to predictions, the N‐amination of Trp9 or Phe33 did not give an increase in the thermal stability of DS119. MD simulations suggest this is due to the highly fluctuating nature of the β‐sheet region. ABSTRACT The miniprotein DS119 has
Yushi Qiao, Syrah K. Starnes, Jožica Dolenc, Juan R. Del Valle, Lorna J. Smith   +4 more
wiley   +1 more source

Synthesis of Substituted Acyclic and Cyclic N-Alkylhydrazines by Enzymatic Reductive Hydrazinations. [PDF]

Chembiochem
Borlinghaus N, Calabrese D, Lauterbach L, Nestl BM.   +3 more
europepmc   +1 more source

Dimensionality Engineering of 1D, 2D, and 3D High‐Entropy Alloys for Advanced Electrocatalysis

Small Structures, Volume 7, Issue 5, May 2026.
This review summarizes recent advances in the synthesis and electrocatalytic applications of high‐entropy alloys (HEAs) in 1D, 2D, and 3D forms. We highlight the unique structural advantages and superior performance of dimensionally engineered HEA in key electrocatalytic reactions, including water splitting, hydrogen oxidation, alcohol oxidation, CO2 ...
Jing Yang, Deyang Xu, Peixin Zhang, Congxu Wang, Shuang Wang, Zhigang Hu, Tian Tian   +6 more
wiley   +1 more source

Visible-light induced trifluoromethylation/cyclization cascade to access CF₃-containing pyrazolones by EDA complex. [PDF]

RSC Adv
Liu Z, Hu M, Gao S, Wei P, Zhao M, Sun Y, Zhang ZH.   +6 more
europepmc   +1 more source

In Vitro Metabolism and Analytical Characterization of SLU‐PP‐332 and SLU‐PP‐915: Novel Pan‐ERR Agonists With Doping Potential

Rapid Communications in Mass Spectrometry, Volume 40, Issue 8, 30 April 2026.
ABSTRACT Rationale Estrogen‐related receptor (ERR) agonists such as the drug candidates SLU‐PP‐332 and SLU‐PP‐915 are currently being investigated as exercise mimetics, given their ability to trigger human physiological processes similar to those initiated by actual physical activity.
Tristan Möller, Oliver Krug, Mario Thevis   +2 more
wiley   +1 more source