Results 191 to 200 of about 9,914 (265)

Severe aplastic anemia as a rare autoimmune complication of ankylosing spondylitis: A rare case report. [PDF]

Medicine (Baltimore)
Alkhen R, Alswij MA, Musleh M, Mohsen Y, ALHusein Q.   +4 more
europepmc   +1 more source

Design, Synthesis, and Biological Evaluation of Pyrazolyl Thioureas (PTUs) as SIRT1 and SIRT2 Inhibitors

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Pyrazolyl thioureas were designed and synthesized as sirtuin 1 (SIRT1) and sirtuin 2 (SIRT2) inhibitors. 6a (IC50 (SIRT1) = 5.3 µM; IC50 (SIRT2) = 2.2 µM) and 7f (IC50 (SIRT1) = 12.4 µM; IC50 (SIRT2) = 13.6 µM) showed micromolar inhibition on target enzymes and HepG2‐based assays confirmed a SIRT2‐mediated effect on tubulin acetylation. Docking studies
Matteo Lusardi, Cecilia Astigiano, Deianira Bellitto, Matteo Raineri, Giorgia Guccione, Annalisa Salis, Elena Cichero, Chiara Brullo, Marco Ponassi, Santina Bruzzone, Andrea Spallarossa   +10 more
wiley   +1 more source

Rational design of tetrahydrotetrazinones as potent nonclassical radical-trapping antioxidants for inhibition of ferroptosis. [PDF]

Sci Adv
Ouyang C, Huang J, Wu Z.
europepmc   +1 more source

Synthetic Strategies of Fused Triazole Frameworks: A Comprehensive Review. [PDF]

ACS Omega
Tamminana R, Mohammed A.
europepmc   +1 more source

Insights on Regioselective Synthesis of Fused Thiazoles: Density Functional Theory Calculations, Local Reactivity Indices, and Molecular Electrostatic Potential Analysis. [PDF]

ChemistryOpen
Al-Hazmi GH, Al-Humaidi JY, Riyadh SM, Ahmed MSM, Zaki MEA, Alruwaili AH, Alanazi KA, Almutairi RH, Gomha SM.   +8 more
europepmc   +1 more source

Access to Nitrogen-nitrogen Bond-Containing Heterocycles Through Substrate Promiscuity of Piperazate Synthases. [PDF]

ACS Catal
Li Y, Osipyan A, de Kok NAW, Schröder S, Founti M, Fodran P, van Merkerk R, Maier A, Tischler D, Schmidt S.   +9 more
europepmc   +1 more source

Expanding the Scope of 1,2‐Diazepines Through Alternative Activation Strategies

European Journal of Organic Chemistry, Volume 29, Issue 35, 19 September 2026.
Often overlooked due to tedious synthetic routes, 1,2‐diazepines can be found in handful of biorelevant molecules. Previous reports from our group lifted the principal synthetic lock: a rapid and user‐friendly protocol to reach monocyclic 1,2‐diazepines from readily available pyridines and electrophilic activating groups. Herein, we extend the scope of
Alexis Leblais, Diego Robles, Aurélie Damond, Xavier Moreau, Clément Ghiazza   +4 more
wiley   +1 more source

From "Undetectable" to "Sensitive Detection": Advances in Derivatization Techniques for LC-MS Analysis of Genotoxic Impurities. [PDF]

Molecules
Wang X, Chen Z, Ji S.
europepmc   +1 more source

Breaking the Ceiling of Boron‐Boron Bonds: Understanding and Fine‐Tuning Basicity in Diborane(4) Complexes

Journal of Computational Chemistry, Volume 47, Issue 24, September 15, 2026.
Diborane(4) can form strong complexes with one or two nitrogen bases, and still behave as a boron base. Complexed with two nitrogen bases, diborane(4) may reach very high proton affinities, overcoming that of the typical 1,8‐bis(dimethylamino)naphthalene super sponge. However, understanding basicity trends is not straightforward, due to the loss of the
Manuel Yáñez, Otilia Mó, M. Merced Montero‐Campillo, Ibon Alkorta   +3 more
wiley   +1 more source

Ti-catalyzed 1,2-Diamination of Alkynes Using 1,1-Disubstituted Hydrazines. [PDF]

J Am Chem Soc
Karmakar PS, Kakiuchi Y, Kim J, Harris MR, Huh DN, Sell AG, Copéret C, Tonks IA.   +7 more
europepmc   +1 more source