Results 61 to 70 of about 2,558 (239)

Synthesis of Trifluoromethylated Pyrazolidines, Pyrazolines and Pyrazoles via Divergent Reaction of CF31,3-Enynes with Hydrazines

, 2021
Three types of trifluoromethylated pyrazolidines, pyrazolines, and pyrazoles can be synthesized via divergent reaction of β-CF3-1, 3-enyne with hydrazines. The reaction with simple hydrazine monohydrate or sulfonyl hydrazines as nucleophiles produces 1,3,
Zongxiang Yu, Zongxiang Yu (11457573), Yuanjing Xiao (1821772), Mingqing Liu, Lan Wei, Lan Wei (244030), Yuanjing Xiao, Mingqing Liu (9356242), Shiteng Ding, Shiteng Ding (11457570)   +9 more
core   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Selenium Nanomaterials for Wound Healing: Synergistic Strategies from Anti‐Infection to Tissue Regeneration

Advanced NanoBiomed Research, EarlyView.
Selenium nanoparticles (SeNPs) are emerging as multifunctional platforms for wound healing, integrating antimicrobial, anti‐inflammatory, and proregenerative activities. This review summarises key mechanisms and recent advances in SeNP‐enabled composite dressings, immunomodulatory nanocomposites, microenvironment‐responsive hydrogels, photothermal and ...
Yangxia Chen, Xiaoshuang Liang, Sirui Li, Shuoshan Li, Wei Liu, Yingping Lin, Siqi Li, Zehang Zhang, Judun Zheng, Tianfeng Chen, Rongyi Chen   +10 more
wiley   +1 more source

Auf dem Weg zu chromoselektiven Transformationen in biologischen Systemen: Perspektiven und Herausforderungen

Angewandte Chemie, EarlyView.
Die Kontrolle biologischer Systeme mit organischen Chromophoren hat sich zu einer vielversprechenden Strategie entwickelt und findet Anwendung von der chemischen Biologie bis hin zur Medizin. Die Komplexität von In‐vivo‐Systemen lässt sich jedoch nicht mit nur einer einzigen Lichtwellenlänge adäquat abbilden.
Nadja A. Simeth
wiley   +1 more source

Copper-Catalysed Ring Opening of Polycyclic meso-Hydrazines with Trialkylaluminium Reagents and SimplePhos Ligands

, 2010
meso-Hydrazines could be desymmetrised by ring-opening reactions by using various metal catalysts to form substituted cyclopentenes, which have a high synthetic potential.
Palais, Laetitia, Alexakis, Alexandre, Bournaud, Chloée, Micouin, Laurent   +3 more
core   +1 more source

Funktionalisierung von Peptiden auf der festen Phase im späten Synthesestadium

Angewandte Chemie, EarlyView.
Peptidmodifikationen sind für die Kontrolle der Eigenschaften von Peptidwirkstoffen von entscheidender Bedeutung. Daher sind Strategien, die einen effizienten und schnellen Einbau nicht‐kanonischer Modifikationen in Peptide in Parallelformaten ermöglichen, sehr gefragt.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

The synthesis and properties of some hydrazines [PDF]

A new synthetic method, applicable to the preparation of a wide range of hydrazine derivatives, is described. This involves the diborane reduction of a hydrazone, or, more conveniently, the reductive-condensation of a hydrazine and the appropriate ...
Gardner, R.J.
core  

Desymmetrization of meso-Bicyclic Hydrazines by Rhodium-Catalyzed Enantioselective Hydroformylation

, 2008
International audienceAn asymmetric hydroformylation of three meso-bicyclic hy-drazines followed by the reduction of the formyl product afforded the corresponding desymmetrized optically enriched hydroxymethyl hydrazines (up to 77.5 % ee)
Francine Agbossou‐Niedercorn, Agbossou-Niedercorn, Francine, Laurent Micouin, Lecourt, Thomas, Chloée Bournaud, Bournaud, Chloée, Micouin, Laurent, Méliet, Catherine, Thomas Lecourt, Catherine Méliet   +9 more
core   +1 more source

Copper-catalysed enantioconvergent N-alkylation of hydrazines with racemic α-haloamides to access enantioenriched hydrazines

Nature Communications
Chiral hydrazines are important building blocks in chiral drug molecules, N-amino peptides, and aza-heterocycles. The catalytic enantioconvergent N-alkylation of readily available hydrazine derivatives with various racemic alkyl halides offers a highly ...
Nan Li, Sheng-Yu He, Peng-Fei Wang, Qiang-Shuai Gu, Zhong-Liang Li, Ji-Jun Chen, Xin-Yuan Liu   +6 more
doaj   +1 more source

Combinatorial Libraries on Rigid Scaffolds: Solid Phase Synthesis of Variably Substituted Pyrazoles and Isoxazoles

Molecules, 1997
The synthesis of combinatorial compound libraries has become a powerful lead finding tool in modern drug discovery. The ability to synthesize rapidly, in high yield, new chemical entities with low molecular weight on a solid support has a recognized ...
Eduard R. Felder, Andreas L. Marzinzik
doaj   +1 more source