Results 51 to 60 of about 129,059 (200)

Synthesis and Antibacterial Activity of New Spiro[thiadiazoline‐(pyrazolo[3,4‐d]pyrimidine)] Derivatives

Journal of Chemistry, Volume 2015, Issue 1, 2015., 2015
New heterocyclic compounds spiroderivatives of allopurinol of biological interest were prepared from allopurinol via thionation and 1,3‐dipolar cycloaddition and were produced in high to excellent yields. These compounds were characterized on the basis of spectral and spectroscopic data (1H NMR, 13C, IR, and MS).
Mohammed El Fal, Youssef Ramli, Abdelfettah Zerzouf, Ahmed Talbaoui, Youssef Bakri, El Mokhtar Essassi, Marco Radi   +6 more
wiley   +1 more source

1,3,4-Thiadiazoles of pharmacological interest: Recent trends in their synthesis via tandem 1,3-dipolar cycloaddition: Review

Journal of Advanced Research, 2014
This review article presents a survey of the utility of a new synthetic strategy for 1,3,4-thiadiazole derivatives based on reactions of nitrilimines with various functionalized sulfur dipolarophiles which proceed via tandem in situ 1,3-dipolar ...
Ahmad S. Shawali
doaj   +1 more source

Synthesis, Molecular Docking Study, and Cytotoxic Activity against MCF Cells of New Thiazole–Thiophene Scaffolds

Molecules, 2022
Investigating novel compounds that may be useful in designing new, less toxic, selective, and potent breast anticancer agents is still the main challenge for medicinal chemists.
Sobhi M. Gomha, Sayed M. Riyadh, Bader Huwaimel, Mohie E. M. Zayed, Magda H. Abdellattif   +4 more
doaj   +1 more source

Fused Imidazopyrazoles: Synthetic Strategies and Medicinal Applications

Journal of Chemistry, Volume 2014, Issue 1, 2014., 2014
The current review summarizes the known synthetic routes of fused imidazopyrazoles. This review is classified into two main categories based on the type of annulations, for example, annulation of the imidazole ring onto a pyrazole scaffold or annulation of the pyrazole ring onto an imidazole scaffold. Some medicinal applications of imidazopyrazoles are
Rizk E. Khidre, Bakr F. Abdel-Wahab, Othman Y. Alothman, Liviu Mitu   +3 more
wiley   +1 more source

Benzo[1,5]thiazepine: Synthesis, Reactions, Spectroscopy, and Applications

Organic Chemistry International, Volume 2013, Issue 1, 2013., 2013
This review article deals with synthesis and reactions of benzo[1,5]thiazepines and the related derivatives and their applications, biological activity as well as spectroscopic data. Most of the reported data on the methods of synthesis, chemical reactions, and biological activity of these heterocycles published over the last ten years are reviewed in ...
Khairy A. M. El-Bayouki, William Setzer
wiley   +1 more source

Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole Derivatives

Molecules, 2012
New series of 1,3,4-thiadiazoles have been prepared via reaction of 1,3,4-thiadiazolenaminones 1 with N-phenyl 2-oxopropanehydrazonoyl chloride (2) in dioxane in the presence of triethylamine.
Mohamed R. Abdel Aziz, Magda A. Abdallah, Thoraya A. Farghaly   +2 more
doaj   +1 more source

Synthesis of Pyrido[2,3‐d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor‐Targeted Molecular Docking Toward Novel Anticancer Leads

ChemistryOpen, EarlyView.
New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha, Sami A. Al‐Hussain, Basant Farag, AbdElAziz A. Nayl, Wesam Hussein, Abdelwahed R. Sayed, Magdi E. A. Zaki   +6 more
wiley   +1 more source

Synthetic Methods, Chemistry, and the Anticonvulsant Activity of Thiadiazoles

International Journal of Medicinal Chemistry, Volume 2013, Issue 1, 2013., 2013
The chemistry of heterocyclic compounds has been an interesting field of study for a long time. Heterocyclic nucleus 1,3,4‐thiadiazole constitutes an important class of compounds for new drug development. The synthesis of novel thiadiazole derivatives and investigation of their chemical and biological behavior have gained more importance in recent ...
Bhawna Sharma, Amita Verma, Sunil Prajapati, Upendra Kumar Sharma, Hussein El-Subbagh   +4 more
wiley   +1 more source

3-Amino-8-hydroxy-4-imino-6-methyl-5-phenyl-4,5-dihydro-3H-chromeno [2,3-d ]pyrimidine: An Effecient Key Precursor for Novel Synthesis of Some Interesting Triazines and Triazepines as Potential Anti-Tumor Agents

Molecules, 2012
A number of interesting heterocycles were prepared through interaction of the intermediate 3-amino-8-hydroxy-4-imino-6-methyl-5-phenyl-4,5-dihydro-3H-chromeno-[2,3-d]pyrimidine (1) and reagents such as hydrazonyl halides 2 to furnish triazine derivatives
Sobhi M. Gomha, Mohamed G. Badrey
doaj   +1 more source

Novel Antimicrobial Agents: Fluorinated 2‐(3‐(Benzofuran‐2‐yl) pyrazol‐1‐yl)thiazoles

International Journal of Medicinal Chemistry, Volume 2013, Issue 1, 2013., 2013
A new series of 2‐pyrazolin‐1‐ylthiazoles 8a–d and 13–16 was synthesized by cyclization of N‐thiocarboxamide‐2‐pyrazoline with different haloketones and 2,3‐dichloroquinoxaline. The structures of the new compounds were confirmed by elemental analyses as well as NMR, IR, and mass spectral data.
Hanan A. Mohamed, Ehab Abdel-Latif, Bakr F. Abdel-Wahab, Ghada E. A. Awad, Armando Rossello   +4 more
wiley   +1 more source