Results 1 to 10 of about 21,823 (203)

Bioequivalence and Food Effect Assessment of Two Fixed‐Dose Combination Formulations of Telmisartan‐Hydrochlorothiazide Tablets in Chinese Healthy Subjects [PDF]

Clinical and Translational Science
This study assessed the bioequivalence and food effect of two fixed‐dose combination (FDC) formulations of telmisartan‐hydrochlorothiazide tablets (telmisartan 40 mg, hydrochlorothiazide 12.5 mg) in healthy Chinese subjects.
Minwan Hu, Man Yang, Shuyu Zhang, Jiangfan Li, Hongxian Pang, Yingzi Pei, Chao Guo, Xuhong Wang   +7 more
doaj   +2 more sources

Dual antihypertensive strategies: A real-world comparative study of efficacy and safety of fixed-dose combinations in a tertiary care setting [PDF]

Perspectives in Clinical Research
Aim: The aim of this study was to evaluate the comparative efficacy and safety of fixed-dose combinations of amlodipine 5 mg + hydrochlorothiazide 12.5 mg (A+H) (Group 1), telmisartan 40 mg + hydrochlorothiazide 12.5 mg (T+H) (Group 2), and ramipril 5 mg
Madhumita Dixit, Rakesh Chandra Chaurasia, Dwividendra Kumar Nim, Manoj Kumar Mathur   +3 more
doaj   +2 more sources

The probiotic <i>Limosilactobacillus fermentum</i> CECT5716 enhances the antihypertensive response to hydrochlorothiazide in spontaneously hypertensive rats. [PDF]

Gut Microbes
González-Correa C, Miñano S, Moleón J, Toral M, Robles-Vera I, Sánchez M, Jiménez R, Olivares M, Martín-Morales N, O'Valle F, Guerra-Hernández E, Romero M, Gómez-Guzmán M, Duarte J.   +13 more
europepmc   +2 more sources

Long-term hydrochlorothiazide use and risk of cutaneous neoplasms

Current Medical Issues, 2021
Background: Hydrochlorothiazide is a diuretic commonly used in the treatment of hypertension. Recently, there have been published reports of hydrochlorothiazide-induced cutaneous neoplasms among Caucasians.
Heber Rew Bright, Sujith J Chandy, Renu George, Meera Thomas, Pradeep Rajkumar, Anju George   +5 more
doaj   +1 more source

Chronic Use of Hydrochlorothiazide and Risk of Skin Cancer in Caucasian Adults: A PharmLines Initiative Inception Cohort Study

Acta Dermato-Venereologica, 2023
Photosensitizing properties of hydrochlorothiazide may increase skin cancer risk. To date, study findings on the association between hydrochlorothiazide use and skin cancer risk are inconsistent, notably regarding confounding and dose-response.
Marjolijn S. Haisma, Nathalie Greven, Mathanhy Logendran, Jens Bos, Bert v.d. Vegt, Barbara Horváth, Stijn de Vos, Geertruida H. de Bock, Eelko Hak, Emőke Rácz   +9 more
doaj   +1 more source

Additional risk factors associated with symptomatic hydrochlorothiazide-induced hyponatremia in hypertensive patients

Arterial Hypertension, 2020
BACKGROUND: Hydrochlorothiazide is a cheap and effective antihypertensive agent but may cause hyponatremia. Even though several risk factors for hydrochlorothiazide-induced hyponatremia have been reported, this study aimed to evaluate additional risk ...
Paiboon Chattakul, Panuwat Napinkul, Sittichai Khamsai, Panita Limpawattana, Jarin Chindaprasirt, Verajit Chotmongkol, Songkwan Silaruks, Vichai Senthong, Laddawan Yuenyaow, Supasson Wansutha, Akkaranee Timinkul, Chalongchai Phitsanuwong, Kittisak Sawanyawisuth   +12 more
doaj   +1 more source

Chemometric Methods for Simultaneous Determination of Candesartan Cilexetil and Hydrochlorothiazide in Binary Combinations

Journal of Analytical Methods in Chemistry, 2023
Simple, accurate, precise, and cost-effective chemometric techniques for the measurement of candesartan cilexetil and hydrochlorothiazide in synthetic mixtures were improved and validated.
Diyar Salahuddin Ali
doaj   +1 more source

Simultaneous Determination of Candesartan and Hydrochlorothiazide in Human Plasma by HPLC-MS/MS

Разработка и регистрация лекарственных средств, 2021
Introduction. Combined drugs have the greatest efficacy and safety in arterial hypertension treatment. The combination of candesartan and hydrochlorothiazide (AT1-receptor antagonist and a thiazide diuretic, respectively) provides high efficiency of ...
P. K. Karnakova, T. N. Komarov, O. A. Archakova, D. S. Shchelgacheva, A. A. Aleshina, N. S. Bagaeva, P. A. Karpova, I. E. Shohin   +7 more
doaj   +1 more source

Vitamin B12 protects against DNA damage induced by hydrochlorothiazide

Saudi Pharmaceutical Journal, 2018
DNA damage induced by hydrochlorothiazide was previously reported in cultured human lymphocytes. In this study, we aimed to investigate the harmful effects of hydrochlorothiazide on DNA by measuring the spontaneous frequency of sister chromatid exchanges
Karem H. Alzoubi, Erva Bayraktar, Omar Khabour, Sayer I. Al-Azzam   +3 more
doaj   +1 more source

Hydrochlorothiazide Potentiates Contractile Activity of Mouse Cavernosal Smooth Muscle

Sexual Medicine, 2016
Introduction: Hydrochlorothiazide has a negative influence on penile erection but little is known about the mechanism(s) involved. Aims: To characterize the effects of this diuretic on mouse corpus cavernosum (CC) smooth muscle in vitro and ex vivo ...
Thiago Gagliano-Jucá, MD, PhD, Mauro Napolitano, PhD, Fernanda Del Grossi Ferraz Carvalho, PhD, Rafael Campos, MPhil, Fabíola Zakia Mónica, PhD, Mário Angelo Claudino, PhD, Edson Antunes, PhD, Anibal Gil Lopes, MD, PhD, Gilberto De Nucci, MD, PhD   +8 more
doaj   +1 more source