Results 71 to 80 of about 35,744 (252)

Advancing antihypertensive drug development

British Journal of Pharmacology, EarlyView.
Hypertension affects more than a billion individuals worldwide and remains a major cause of cardiovascular morbidity and mortality. Despite advances in therapies, optimal blood pressure control remains elusive for many patients because of treatment resistance, adverse effects, and adherence challenges.
Fay Pu, Yanrong Liu, Fozia Zahir Ahmed, Xin Wang, Darren Green, Hongyuan Zhang   +5 more
wiley   +1 more source

The combination therapy in arterial hypertension: opportunities of the fixed combination of irbesartan andhydrochlorothiazide(Koaprovel’) [PDF]

Системные гипертензии, 2014
The article deals with the various aspects of the combinationtherapyin arterial hypertension. We showed the complementary effects and benefits of the combination of angiotensin II receptor antagonistsand diuretics; also we described clinical caseswhere ...
O D Ostroumova, T F Guseva, O V Bondarets   +2 more
doaj  

Study protocol for a cluster-randomized controlled trial of an NCD access to medicines initative: Evaluation of Novartis Access in Kenya [PDF]

, 2016
INTRODUCTION: Novartis recently launched Novartis Access, an initiative to provide a basket of reduced price medicines for non-communicable diseases (NCDs) to be sold through the public and private nonprofit sectors in programme countries.
Ashigbie, Paul G., Laing, Richard, Onyango, Monica A., Rockers, Peter C., Vian, Taryn, Wirtz, Veronika J.   +5 more
core   +1 more source

Lymphocyte Transformation Tests and Patch Tests to Identify Drugs Potentially Associated With Bullous Pemphigoid Development

International Journal of Dermatology, EarlyView.
ABSTRACT Background Bullous pemphigoid (BP) is the most common autoimmune blistering disease, with a rising incidence in the elderly. BP is associated with multiple triggering factors, including drug exposure. However, evidence in this respect is limited, and the underlying immune mechanisms remain unknown.
Belen de Nicolas‐Ruanes, Carlos Fernandez‐Lozano, Patricia Gutierrez‐Canales, Asuncion Ballester‐Martinez, Natalia Rodriguez‐Otero, Javier Martinez‐Botas, Belén de la Hoz Caballer, Ana Andres‐Martin, Emilio Solano‐Solares, Maria Esther Gomez‐Salazar Lopez‐Silanes, Laura Gisella Diaz‐Montalvo, Diana M. Arrebola, Vivian Lizeth Stewart‐Delcid, Emilio Garcia‐Mouronte, Carlos Azcarraga‐Llobet, Emilio Berna‐Rico, Sonia Ortega‐Sanchez, Montserrat Fernandez‐Guarino   +17 more
wiley   +1 more source

The choice of antihypertensive therapy in correction of cognitive impairments and prevention of dementia: possibilities of valsartan and fixed-dose combination of valsartan and hydrochlorothiazide [PDF]

Системные гипертензии, 2016
This article discusses the definition, classification and pathogenetic mechanisms of cognitive functions in arterial hypertension. The authors discuss the capabilities of the different classes of antihypertensive drugs in correction of cognitive ...
O D Ostroumova, I A Garelik, E A Karavashkina   +2 more
doaj  

Roselle (Hibiscus sabdariffa L.) extract as an adjunct to valsartan in patients with mild chronic kidney disease: A double-blind randomized controlled clinical trial [PDF]

Avicenna Journal of Phytomedicine
Objective: The objective of this study was to evaluate theeffectiveness of Hibiscus sabdariffa L. extract (HS) as an adjunctto valsartan in the treatment of high blood pressure in patients withmild chronic kidney disease (CKD).Materials and Methods: This
Behdad Dehkhoda, Ayesheh Enayati, Hassan Mirzaei, Somayeh Ghorbani, Mohammad Hadi Soleimani, Saeid Amirkhanlou, Amirhossein Sahebkar   +6 more
doaj   +1 more source

Real‐World Complexity of Prescribing Cascades

Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 1, July 2025.
ABSTRACT Prescribing cascades occur when an adverse drug reaction (ADR) to one medication is treated with additional medication. Most literature focusses on this simplistic singular concept of one medication followed by another. However, ADRs in clinical practice may appear less straightforward, making prescribing cascades difficult to identify and ...
J. T. H. Nielen, K. van der Walle, S. H. Spronk, F. J. H. Magdelijns, P. Denig, F. Karapinar‐Çarkıt   +5 more
wiley   +1 more source

Calcium channel blockers, more than diuretics, enhance vascular protective effects of angiotensin receptor blockers in salt-loaded hypertensive rats. [PDF]

PLoS ONE, 2012
The combination therapy of an angiotensin receptor blocker (ARB) with a calcium channel blocker (CCB) or with a diuretic is favorably recommended for the treatment of hypertension.
Eiichiro Yamamoto, Keiichiro Kataoka, Yi-Fei Dong, Nobutaka Koibuchi, Kensuke Toyama, Daisuke Sueta, Tetsuji Katayama, Osamu Yasuda, Hisao Ogawa, Shokei Kim-Mitsuyama   +9 more
doaj   +1 more source

Sporadic Porphyria Cutanea Tarda, Cutaneous Sarcoidosis, and Compound Heterozygosity of HFE Mutations Cys282Tyr and His63Asp—A Case Report

eJHaem, Volume 6, Issue 3, June 2025.
ABSTRACT Porphyria cutanea tarda (PCT) is caused by inherited or acquired defects of uroporphyrinogen decarboxylase (UROD) in the heme biosynthetic pathway. Altered iron homeostasis via hemochromatosis gene (HFE) mutations is one of many susceptibility factors associated with the sporadic form of PCT.
Jowon L. Kim, Richard Crawford, Ian Marie Lano, Hayley Merkeley   +3 more
wiley   +1 more source

FIXED COMBINATION OF RAMIPRIL AND HYDROCHLOROTHIAZIDE: TO WHOM AND WHAT FOR?

Российский кардиологический журнал, 2016
The article focuses on the "pros" and "contras" of thiazide containing combinations usage for treatment of arterial hypertension in real clinical practice.
S. V. Nedogoda
doaj   +1 more source