Results 21 to 30 of about 164,153 (386)

Association of mortality with fludrocortisone addition to hydrocortisone treatment among septic shock patients: a propensity score matching analysis

Frontiers in Medicine, 2023
BackgroundSeveral clinical trials of corticosteroids have been carried out in the treatment of septic shock, however, the therapeutic effect of the most widely used hydrocortisone is still controversial, and no studies have directly compared ...
Xiaoxiao Cheng, Zhiqin Fu, Yiting Liu, Xiaoyu Zheng, Tianyang Hu   +4 more
doaj   +1 more source

Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2021
Importance Sepsis is a common syndrome with substantial morbidity and mortality. A combination of vitamin C, thiamine, and corticosteroids has been proposed as a potential treatment for patients with sepsis. Objective To determine whether a combination
J. Sevransky, R. Rothman, D. Hager, G. Bernard, Samuel M. Brown, T. Buchman, L. Busse, C. Coopersmith, C. DeWilde, E. W. Ely, L. Eyzaguirre, A. Fowler, D. Gaieski, M. Gong, A. Hall, J. Hinson, M. Hooper, G. Kelen, Akram Khan, M. Levine, R. Lewis, C. Lindsell, Jessica S Marlin, A. McGlothlin, Brooks L. Moore, K. Nugent, S. Nwosu, C. Polito, T. Rice, E. Ricketts, C. Rudolph, Fred Sanfilippo, K. Viele, G. Martin, D. Wright   +34 more
semanticscholar   +1 more source

Hydrocortisone to Improve Survival without Bronchopulmonary Dysplasia.

New England Journal of Medicine, 2022
BACKGROUND Bronchopulmonary dysplasia is a prevalent complication after extremely preterm birth. Inflammation with mechanical ventilation may contribute to its development.

semanticscholar   +1 more source

Modified-Release Hydrocortisone in Congenital Adrenal Hyperplasia

Journal of Clinical Endocrinology and Metabolism, 2021
Context Standard glucocorticoid therapy in congenital adrenal hyperplasia (CAH) regularly fails to control androgen excess, causing glucocorticoid overexposure and poor health outcomes.
Merke Dp, M. A, A. W, B. a, Linden Hirschberg A, Juul A, N. J., Perry Cg, Prete A, Rees Da, Reisch N, Stikkelbroeck N, Touraine P, Maltby K, T. Fp, P. J, Rosser Rj   +16 more
semanticscholar   +1 more source

Effect of stress doses of hydrocortisone on S-100B vs. interleukin-8 and polymorphonuclear elastase levels in human septic shock [PDF]

, 2005
Stress doses of hydrocortisone a re known to have immunomodulatory effects in patients with hyperdynamic septic shock. The prognosis correlates with the presence and severity of septic encephalopathy. However, neurological evaluation is influenced by the
Anderson, Annane, Astudillo, Barie, Barie, Bastos, Bertsch, Blomquist, Bollaert, Bolton, Bolton, Bone, Briegel, Briegel, Briegel, Briegel, Danielson, Donato, Eidelman, Endo, Haimoto, Herrmann, Hollenberg, Hund, Hund, Jonsson, Keh, Lindner, Marshall, Metinko, Munck, Mussack, Mussack, Pelinka, Pelinka, Rosen, Schwarz, Stanimirovic, Usui, Vincent, Waage, Weiss, Westaby, Wheeler, Wiesmann, Wunderlich, Young   +46 more
core   +2 more sources

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2020
Importance Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants An ongoing
D. Angus, L. Derde, Farah Al-Beidh, D. Annane, Y. Arabi, A. Beane, Wilma van Bentum-Puijk, L. Berry, Zahra Bhimani, M. Bonten, C. Bradbury, F. Brunkhorst, M. Buxton, Adrian Buzgau, A. Cheng, M. D. de Jong, M. Detry, L. Estcourt, M. Fitzgerald, H. Goossens, Cameron Green, R. Haniffa, A. Higgins, Christopher M. Horvat, Sebastiaan J. Hullegie, P. Kruger, F. Lamontagne, P. Lawler, K. Linstrum, E. Litton, E. Lorenzi, J. Marshall, D. McAuley, Anna McGlothin, S. McGuinness, B. McVerry, S. Montgomery, P. Mouncey, S. Murthy, A. Nichol, R. Parke, Jane C. Parker, K. Rowan, A. Sanil, Marlene S. Santos, Christina T. Saunders, Christopher Seymour, Anne M Turner, F. L. van de Veerdonk, B. Venkatesh, R. Zarychanski, S. Berry, R. Lewis, C. McArthur, S. Webb, A. Gordon   +55 more
semanticscholar   +1 more source

Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2020
Importance Coronavirus disease 2019 (COVID-19) is associated with severe lung damage. Corticosteroids are a possible therapeutic option. Objective To determine the effect of hydrocortisone on treatment failure on day 21 in critically ill patients with ...
P. Dequin, N. Heming, F. Meziani, G. Plantefeve, G. Voiriot, J. Badie, B. François, C. Aubron, J. Ricard, S. Ehrmann, Y. Jouan, A. Guillon, M. Leclerc, Carine Coffre, H. Bourgoin, C. Lengellé, Caroline Caille-Fénérol, E. Tavernier, S. Zohar, B. Giraudeau, D. Annane, A. Le Gouge   +21 more
semanticscholar   +1 more source

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2020
Importance It is unclear whether vitamin C, hydrocortisone, and thiamine are more effective than hydrocortisone alone in expediting resolution of septic shock.
T. Fujii, N. Luethi, P. Young, D. Frei, G. Eastwood, C. French, A. Deane, Y. Shehabi, L. Hajjar, G. Oliveira, A. Udy, N. Orford, S. Edney, A. Hunt, H. Judd, L. Bitker, L. Cioccari, T. Naorungroj, Fumitaka Yanase, S. Bates, F. McGain, Elizabeth P Hudson, W. Al-Bassam, D. B. Dwivedi, C. Peppin, P. Mccracken, J. Orosz, M. Bailey, R. Bellomo   +28 more
semanticscholar   +1 more source

A prospective, randomised clinical study comparing triple therapy regimen to hydrocortisone monotherapy in reducing mortality in septic shock patients

International journal of clinical practice, 2021
This prospective, comparative and randomised clinical study evaluated the effectiveness of triple therapy regimen (hydrocortisone, thiamine and vitamin C) versus hydrocortisone alone in reducing the mortality rate and preventing progressive organ ...
Abdelrhman A Hussein, N. Sabry, Maged Abdalla, S. Farid   +3 more
semanticscholar   +1 more source

Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock. [PDF]

PLoS ONE, 2014
BACKGROUND:Previous investigations and meta-analyses on the effect of glucocorticoids on mortality in septic shock revealed mixed results. This heterogeneity might be evoked by genetic variations. Such candidate is a promoter polymorphism (-94ins/delATTG)
Simon T Schäfer, Sophia Gessner, André Scherag, Katharina Rump, Ulrich H Frey, Winfried Siffert, Astrid M Westendorf, Jörg Steinmann, Jürgen Peters, Michael Adamzik   +9 more
doaj   +1 more source