Results 21 to 30 of about 175,705 (335)

Effect of Hydrocortisone on 21-Day Mortality or Respiratory Support Among Critically Ill Patients With COVID-19: A Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2020
Importance Coronavirus disease 2019 (COVID-19) is associated with severe lung damage. Corticosteroids are a possible therapeutic option. Objective To determine the effect of hydrocortisone on treatment failure on day 21 in critically ill patients with ...
P. Dequin, Nicholas Heming, F. Meziani, G. Plantefeve, G. Voiriot, J. Badie, B. François, C. Aubron, J. Ricard, S. Ehrmann, Y. Jouan, A. Guillon, M. Leclerc, Carine Coffre, H. Bourgoin, C. Lengellé, Caroline Caille-Fénérol, E. Tavernier, S. Zohar, B. Giraudeau, D. Annane, A. Le Gouge   +21 more
semanticscholar   +1 more source

A prospective, randomised clinical study comparing triple therapy regimen to hydrocortisone monotherapy in reducing mortality in septic shock patients

International journal of clinical practice, 2021
This prospective, comparative and randomised clinical study evaluated the effectiveness of triple therapy regimen (hydrocortisone, thiamine and vitamin C) versus hydrocortisone alone in reducing the mortality rate and preventing progressive organ ...
Abdelrhman A Hussein, N. Sabry, Maged Abdalla, S. Farid   +3 more
semanticscholar   +1 more source

Hydrocortisone fails to abolish NF-κB1 protein nuclear translocation in deletion allele carriers of the NFKB1 promoter polymorphism (-94ins/delATTG) and is associated with increased 30-day mortality in septic shock. [PDF]

PLoS ONE, 2014
BACKGROUND:Previous investigations and meta-analyses on the effect of glucocorticoids on mortality in septic shock revealed mixed results. This heterogeneity might be evoked by genetic variations. Such candidate is a promoter polymorphism (-94ins/delATTG)
Simon T Schäfer, Sophia Gessner, André Scherag, Katharina Rump, Ulrich H Frey, Winfried Siffert, Astrid M Westendorf, Jörg Steinmann, Jürgen Peters, Michael Adamzik   +9 more
doaj   +1 more source

Variations in the management of acute illness in children with congenital adrenal hyperplasia: An audit of three paediatric hospitals [PDF]

, 2018
Objective: Episodes of acute adrenal insufficiency (AI)/adrenal crises (AC) are a serious consequence of congenital adrenal hyperplasia (CAH). This study aimed to assess morbidity from acute illness in CAH and identify factors associated with use of IV ...
Allolio, Bornstein, El-Maouche, Falhammar, Falhammar, Falhammar, Fleming, Gidlof, Gleeson, Hahner, Hahner, Huynh, Ishii, Kampmeyer, Khalid, Leblicq, Maguire, Merke, Neumann, Reisch, Rushworth, Rushworth, Rushworth, Rushworth, Speiser, Swerdlow   +25 more
core   +2 more sources

Evaluation of prophylactic intravenous hydrocortisone for the prevention of postdural puncture headache following spinal anesthesia for cesarean section

Journal of Clinical Sciences, 2020
Context: Postdural puncture headache (PDPH) is a common complication following spinal anesthesia. No medication is currently used on routine basis for its prevention despite its high incidence.
Alaba Olusola Ogunsiji, Babatunde Babasola Osinaike, Simbo Daisy Amanor-Boadu, Gbolahan Oladele Obajimi   +3 more
doaj   +1 more source

A study of impurity profiling via method development and force degradation in hydrocortisone butyrate at low concentration

Future Journal of Pharmaceutical Sciences, 2023
Background Since long, triamcinolone and fluocinolone, fluorinated derivatives, have been used for treating various types of dermatitis. Rosacea and perioral dermatitis are the most common side effects observed with prolonged use of fluorinated ...
Harshwardhan G. Gunjal, Vivek V. Byahatti   +1 more
doaj   +1 more source

Cutaneous Permeation of a Percutaneously Applied Glucocorticoid Using Plant-Based Anionic Phospholipids in Hydrogenated Vegetable Oil: A Preliminary Study

Medicina, 2022
Purpose: It is important that, when corticosteroids are used therapeutically, concentrations be reduced as much as possible to mitigate potential adverse events and side effects.
Jack V. Greiner, Hridaya N. Bhargava, Thomas Glonek, Donald R. Korb, Michael E. Lindsay, Paula J. Oliver   +5 more
doaj   +1 more source

Transcriptome modulation by hydrocortisone in severe burn shock: ancillary analysis of a prospective randomized trial

Critical Care, 2017
Background Despite shortening vasopressor use in shock, hydrocortisone administration remains controversial, with potential harm to the immune system. Few studies have assessed the impact of hydrocortisone on the transcriptional response in shock, and we
Jonathan Plassais, Fabienne Venet, Marie-Angélique Cazalis, Diane Le Quang, Alexandre Pachot, Guillaume Monneret, Sylvie Tissot, Julien Textoris   +7 more
doaj   +1 more source

Mechanisms of burst release from pH-responsive polymeric microparticles. [PDF]

, 2011
Microencapsulation of drugs into preformed polymers is commonly achieved through solvent evaporation techniques or spray drying. We compared these encapsulation methods in terms of controlled drug release properties of the prepared microparticles and ...
Donaldson, M, Green, Rebecca J, Khutoryanskaya, O, Rizi, K, Williams, Adrian C   +4 more
core   +1 more source

Vitamin C Therapy for Routine Care in Septic Shock (ViCTOR) Trial: Effect of Intravenous Vitamin C, Thiamine, and Hydrocortisone Administration on Inpatient Mortality among Patients with Septic Shock

Indian Journal of Critical Care Medicine, 2020
Background Sepsis remains a leading cause of death worldwide despite advances in management strategies. Preclinical and observational studies have found mortality benefit with high-dose vitamin C in sepsis.
Z. Mohamed, Pratibha Prasannan, M. Moni, F. Edathadathil, P. Prasanna, Anup Menon, Sabarish B Nair, C. Greeshma, D. Sathyapalan, Veena P Menon, Vidya P Menon   +10 more
semanticscholar   +1 more source