Results 121 to 130 of about 650 (168)

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Physical mechanism of core-collapse supernovae that neutrinos drive. [PDF]

Proc Jpn Acad Ser B Phys Biol Sci
Yamada S, Nagakura H, Akaho R, Harada A, Furusawa S, Iwakami W, Okawa H, Matsufuru H, Sumiyoshi K.   +8 more
europepmc   +1 more source

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

Advanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao, Bin Gu, Hui Zhao, Kun Tan, Qin Zhao, Zhengjun Shang   +5 more
wiley   +1 more source

Photothermal Amplification via Nanorobotic Swarming Dynamics

Advanced Science, EarlyView.
This study explores a novel approach to enhance photothermal therapy using magnetically regulated microswarms. It details the development of magnetic nanoparticles organized into dynamic structures that improve heat retention and conversion efficiency.
Qinglong Wang, Lin Su, Zhengxin Yang, Yihang Jiang, Haojin Yang, Qianqian Wang, Li Zhang, Ben Wang, Jiajia Wang   +8 more
wiley   +1 more source

Active billiards: Engineering boundaries for the spatial control of confined active particles. [PDF]

Proc Natl Acad Sci U S A
Di Leonardo R, Búzás A, Kelemen L, Tóth D, Tóth SZ, Ormos P, Vizsnyiczai G.   +6 more
europepmc   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Neuronal Synchronization and Bidirectional Activity Spread Explain Efficient Swimming in a Whole-Body Model of Hydrozoan Jellyfish. [PDF]

J Neurosci
Pallasdies F, Norton P, Schleimer JH, Schreiber S.   +3 more
europepmc   +1 more source

Tumor Microenvironment‐Responsive Nanoreactor Induces Disulfidptosis in Pancreatic Cancer via Metabolic Interference and Redox Catalysis

Advanced Science, EarlyView.
Schematic illustration of a tumor microenvironment‐responsive nanoreactor for imaging‐guided induction of disulfidptosis in pancreatic cancer via metabolic interference and redox catalysis. (A) Stepwise fabrication of Pht@HMnO2‐HA, including MnO2 growth on a SiO2 template, template removal to form hollow mesoporous MnO2, Pht loading, and subsequent ...
Rui Fu, Qing Li, Guanzhong Zhao, Qingyan Gao, Huantong Chen, Khemayanto Hidayat, Jiaying Xu, Liqiang Qin, Chunhong Hu, Yu Chong, Su Hu   +10 more
wiley   +1 more source

Effects of inbound attendees of a mass gathering event on the COVID-19 epidemic using individual-based simulations. [PDF]

PLoS One
Saito MM, Katayama K, Naruse A, Ruan P, Murakami M, Okuda T, Ysutaka T, Naito W, Tsubokura M, Imoto S.   +9 more
europepmc   +1 more source

Wood‐Based Bioelectronics: Lignosulfonate‐Based Conductive Biocomposites for Paper Organic Electrochemical Transistors

Advanced Electronic Materials, EarlyView.
Biodegradable wood‐based bioelectronics are realized by integrating poly (2,3‐ethylenedioxythiopene:lignosulfonate (PEDOT:LigS) as a mixed ionicelectronic channel in organic electrochemical transistors fabricated on paper substrates. The biocomposite exhibits high conductivity, biocompatibility, and strong transistor performance, while devices built on
Katharina Matura, Tobias Grabner, Sarka Hradilova, Munise Cobet, Ariana Opletalova, Katerina Polakova, Alessandra Operamolla, Niyazi Serdar Sariciftci, Serpil Tekoglu   +8 more
wiley   +1 more source