Results 81 to 90 of about 822,424 (341)

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Theoretical Studies on Hydrogen Bonds in Anions Encapsulated by an Azamacrocyclic Receptor

Crystals, 2016
Hydrogen bonds in two halides encapsulated by an azamacrocyclic receptor were studied in detail by the density functional theory (DFT) approaches at B3LYP/6-311++G(d,p) and M06-2X/6-311++G(d,p) levels. The atoms in molecules (AIM) theory and the electron
Jing Wang, Jiande Gu, Md. Alamgir Hossain, Jerzy Leszczynski   +3 more
doaj   +1 more source

Purification and characterization of a thermophilic NAD+‐dependent lactate dehydrogenase from Moorella thermoacetica

FEBS Open Bio, EarlyView.
The thermophilic acetogenic model organism Moorella thermoacetica can utilize lactate as substrate. The formation of lactate by reduction of pyruvate is energetically favorable, but the reverse reaction, the oxidation of lactate to pyruvate with NAD+ as electron acceptor is challenging.
Florian P. Rosenbaum, Volker Müller
wiley   +1 more source

Mechanism of deep eutectic solvent on coal spontaneous combustion

Meitan xuebao
Chemical inhibition is one of the important measures for the prevention and control of coal spontaneous combustion. This paper proposed a quasi-ionic liquid inhibition method based on deep eutectic solvents (DES).
Xuyao QI, Tao WANG, Lanjun ZHANG, Jie HU, Haihui XIN, Zhongqiu LIANG   +5 more
doaj   +1 more source

Dimethyl 5-acetyl-1-hydroxy-4-methyl-1H-pyrrole-2,3-dicarboxylate, an oxidation-resistant N-hydroxypyrrole

Acta Crystallographica Section E, 2014
The title compound, C11H13NO6, exhibits an intramolecular O–H...O=C hydrogen bond between the N-hydroxyl H atom and carbonyl O atom of the neighboring acetyl group.
Gerald M. Rosen, Sukumaran Muralidharan, Peter Y. Zavalij, Joseph P. Y. Kao   +3 more
doaj   +1 more source

Golden sections of inter-atomic distances as exact ionic radii of atoms [PDF]

, 2009
The Golden ratio which appears in the geometry of a variety of creations in Nature is found to arise right in the Bohr radius of the hydrogen atom due to the opposite charges of the electron and proton.
Raji Heyrovska
core   +1 more source

IR Spectrum of the O-H$...$O Hydrogen Bond of Phthalic Acid Monomethylester in Gas Phase and in CCl$_4$ Solution

, 2009
The absorption spectrum of the title compound in the spectral range of the Hydrogen-bonded OH-stretching vibration has been investigated using a five-dimensional gas phase model as well as a QM/MM classical molecular dynamics simulation in solution.
Becke, Bratos, Bratos, Carter, Csaszar, Dickey, Gaigeot, Giese, Gireesh M. Krishnan, Henri-Rousseau, Heyne, Jezierska, Jezierska, Kühn, Laio, Lee, Locker, M. Petković, Madsen, Marston, Maréchal, Nibbering, Nibbering, Novak, Oliver Kühn, Paramonov, Rousseau, Sauer, Schneider, Scott, Stare, Stenger, Stenger, Troullier, Yan, Yun-an Yan   +35 more
core   +1 more source

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

FEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma   +7 more
wiley   +1 more source

Imaging Hydrogen Bond in Real Space [PDF]

arXiv, 2013
Hydrogen bond is often assumed to be a purely electrostatic interaction between a electron-deficient hydrogen atom and a region of high electron density. Here, for the first time, we directly image hydrogen bond in real space by room-temperature scanning tunneling microscopy (STM) with the assistance of resonant tunneling effect in double barrier mode.
arxiv  

Adhesion theory review [PDF]

, 1972
Bonding theories reviewed include physical adsorption, hydrogen bonding, chemisorption and surface energy; bond failure mechanisms include phase discontinuity, swelling and corrosion.
Delollis, N. J.
core   +1 more source