Results 71 to 80 of about 875,486 (317)

Investigation of Mechano-Electrochemical Effects on Hydrogen Distribution at Corrosion Defects

Hydrogen
This study employed tensile test, hydrogen permeation measurements, and potentiodynamic polarization testing to investigate the mechanical properties, hydrogen diffusion coefficients, and electrochemical behavior of X80 steel. A multifield coupled finite
Zhixiang Dai, Jiamin Tang, Sijia Zheng, Feng Wang, Qin Bie, Pengcheng Kang, Xinyi Wang, Shiwen Guo, Lin Chen   +8 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

New laminar flame speed correlation for lean mixtures of hydrogen combustion with water addition under high pressure conditions [PDF]

Hydrogen may become a substitute for liquid fossil fuels, contributing to greenhouse gas emissions reductions in internal combustion engines. Numerical simulations play a critical role in the advancement of these engines, with laminar flame speed being ...
Axon, CJ, Megaritis, T, Rrustemi, DN, Ganippa, LC   +3 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Understanding of the intensified effect of super gravity on hydrogen evolution reaction

, 2009
Hydrogen evolution reaction (HER) under super gravity field was studied in 0.5 M H(2)SO(4) aqueous solution by cyclic voltammetry (CV), linear sweep voltammetry (LSV), chronoamperometry and electrochemical impedance spectroscopy (EIS).
Wang, Zhi, Wang, MY, Wang, Mingyong, Guo, Zhancheng   +3 more
core   +1 more source

INVESTIGATION OF HYDROGEN KINETICS OF COPPER PELLETS WITH ENG ADDITIVES [PDF]

, 2022
BAU; et al.; INOGEN; Republic of Turkey, Ministry of Energy and Natural Resources; TENMARK; Turkish Airlines23rd World Hydrogen Energy Conference: Bridging Continents by H2, WHEC 2022 -- 26 June 2022 through 30 June 2022 -- Istanbul -- 186176In this ...
Kaplan, Yuksel, Atalmis, Gamze, Demiralp, Mehmet, Yelegen, Nebi   +3 more
core  

Electron Concept of Hydrogen Embrittlement and Hydrogen-Increased Plasticity of Metals

Успехи физики металлов
Based on theoretical and experimental studies of hydrogen effect on the electron structure of iron, nickel and titanium, an electron concept is proposed for hydrogen embrittlement as well as for hydrogen-improved plasticity of engineering metallic ...
V.G. Gavriljuk, V.M. Shyvaniuk, and S.M. Teus
doaj   +1 more source

Antitumor effects of hydrogen peroxide in vivo [PDF]

The Journal of Experimental Medicine, 1981
Glucose oxidase, covalently coupled to polystyrene microspheres (GOL), produced H(2)0(2) at an average rate of 3.6 nmol/min per 10(9) beads under standard assay conditions. Injection of 1.3 × 10(10) to 1.1 × 10(11) GOL i.p. prolonged the survival of mice by 27 percent after injection of 10(6) P388 lymphoma cells in the same site, consistent with ...
C F, Nathan, Z A, Cohn
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source