Results 61 to 70 of about 875,486 (317)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Significant Quantum Effects in Hydrogen Activation

ACS Nano, 2014
Dissociation of molecular hydrogen is an important step in a wide variety of chemical, biological, and physical processes. Due to the light mass of hydrogen, it is recognized that quantum effects are often important to its reactivity. However, understanding how quantum effects impact the reactivity of hydrogen is still in its infancy.
Kyriakou, G, Davidson, ER, Peng, G, Roling, LT, Singh, S, Boucher, MB, Marcinkowski, MD, Mavrikakis, M, Michaelides, A, Sykes, EC   +9 more
openaire   +3 more sources

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Effect of hydrogen on the corrosion behavior of the Mg–xZn alloys

Journal of Magnesium and Alloys, 2014
Hydrogen evolution reaction is inevitable during the corrosion of Mg alloys. The effect of hydrogen on the corrosion behavior of the Mg–2Zn and Mg–5Zn alloys is investigated by charging hydrogen treatment.
Yingwei Song, En-Hou Han, Kaihui Dong, Dayong Shan, Chang Dong Yim, Bong Sun You   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Study on the influence of ultrasound on the kinetic behaviour of hydrogen bubbles produced by proton exchange membrane electrolysis with water

Ultrasonics Sonochemistry
Ultrasonic technology has a significant degassing effect and can increase the efficiency of hydrogen production in the proton exchange membrane electrolysis of water.
Hongqian Su, Jindong Sun, Caizhu Wang, Haofeng Wang   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Fourth-Generation Fluid Effect In Geothermal-Based Hydrogen Production Combined System

International Journal Of Hydrogen EnergyIn this study, hydrogen production using a Proton Exchange Membrane Electrolyser (PEME) integrated with a geothermal based dual Organic Rankine Cycle (ORC) designed using different organic fluids is investigated ...

core   +1 more source

Hydrogen Embrittlement Susceptibility of Super Duplex Stainless Steels [PDF]

, 2010
This thesis describes the metallurgical and environmental factors that influence hydrogen embrittlement of super duplex stainless steels and presents a model to predict the rate at which embrittlement occurs.
Alsarraf, Jalal
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source