Results 41 to 50 of about 97,085 (317)

[Pd(NHC)(PR3)] complexes : versatile tools for tandem dehydrogenation-hydrogenation processes

, 2013
This work is supported in part by funding from the EPSRC UKHomogeneous Pd(0) complexes are powerful tools for numerous catalytic reactions. Recent work has demonstrated the unique properties displayed by [Pd(NHC)(PR3)] catalysts in the activation of ...
Cazin, Catherine, Cazin, Catherine S.J., Songis, Olivier   +2 more
core   +1 more source

Ligand-controlled regiodivergent and enantioselective C–H cyanation of secondary amines

Nature Communications
Aliphatic amines, such as N,N-dialkyl secondary amines, represent important scaffolds in bioactive molecules, driving significant interest in their regio- and stereoselective C–H functionalisation.
Yang-Jie Mao, Xiahe Chen, Huan-Le Li, Qi Pan, Kun Zhou, Zhen-Yuan Xu, Yun-Fang Yang, Shao-Jie Lou, Dan-Qian Xu   +8 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

C2H2 semi-hydrogenation on the PdxMy cluster/graphdiyne catalysts: Effects of cluster composition and size on the activity and selectivity

Green Energy & Environment, 2022
C2H2 semi-hydrogenation has been widely applied in industry to eliminate trace C2H2 from C2H4 feed. C2H2 semi-hydrogenation to C2H4 on a series of the newly designed catalysts, graphdiyne (GDY) as a new carbon allotrope supported different sizes of PdxMy
Ying Wang, Yamin Qi, Maohong Fan, Baojun Wang, Lixia Ling, Riguang Zhang   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Monolayer via Hydrogenation

, 2022
The realization of two-dimensional (2D) magnetism opens an unprecedented possibility for building future magnetoelectric nanodevices; however, wide application is still restricted by the lack of a material platform with a simultaneously large magnetic ...
Munirah Alsubaie, Tang, Cheng, Munirah, Munirah, Wijethunge, Dimuthu, Aijun Du, Cheng Tang, Dongchen Qi, Qi, Dongchen, Dimuthu Wijethunge, Du, Aijun   +9 more
core   +1 more source

Recent Advances in Iridium-Catalyzed Asymmetric Hydrogenation: New Catalysts, Substrates and Applications in Total Synthesis

CHIMIA, 2012
Iridium-catalyzed asymmetric hydrogenation has emerged as a highly efficient method for the synthesis of enantiomerically pure compounds. This account summarizes our recent efforts in this field.
Adnan Ganić, Denise Rageot, Lars Tröndlin, Andreas Pfaltz   +3 more
doaj   +1 more source

Improvement of the selectivity of isophorone hydrogenation by Lewis acids [PDF]

Royal Society Open Science, 2018
The selective hydrogenation of isophorone (3,5,5-trimethyl-2- cyclohexen-1-one) to produce 3,3,5-trimethylcyclohexanone (TMCH), an important organic solvent and pharmaceutical intermediate, is of significance in industry.
Yucui Hou, Shuhang Ren, Muge Niu, Weize Wu   +3 more
doaj   +1 more source