Results 61 to 70 of about 624,952 (297)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Ambient hydrogenation of solid aromatics enabled by a high entropy alloy nanocatalyst

Nature Communications
Hydrogenation is a versatile chemical process with significant applications in various industries, including food production, petrochemical refining, pharmaceuticals, and hydrogen carriers/safety.
Zekun Jing, Yakun Guo, Qi Wang, Xinrong Yan, Guozong Yue, Zhendong Li, Hanwen Liu, Ruixuan Qin, Changyin Zhong, Mingzhen Li, Dingguo Xu, Yunxi Yao, Yonggang Yao, Maobing Shuai   +13 more
doaj   +1 more source

The Effect of Magnetic Field on Thermal-Reaction Kinetics of a Paramagnetic Metal Hydride Storage Bed

Applied Sciences, 2017
A safe and efficient method for storing hydrogen is solid state storage through a chemical reaction in metal hydrides. A good amount of research has been conducted on hydrogenation properties of metal hydrides and possible methods to improve them ...
Shahin Shafiee, Mary Helen McCay, Sarada Kuravi   +2 more
doaj   +1 more source

Hydrogenation Ability of Mg-Li Alloys

Energies, 2020
The Mg-Li binary system is characterized by the presence of α-Mg(Li) and β-Li(Mg) phases, where magnesium exists in ordered and disordered forms that may affect the hydrogenation properties of magnesium. Therefore, the hydrogenation properties of an AZ31
Magda Pęska, Tomasz Czujko, Marek Polański   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Alloying and confinement effects on hierarchically nanoporous CuAu for efficient electrocatalytic semi-hydrogenation of terminal alkynes

Nature Communications
Electrocatalytic alkynes semi-hydrogenation to produce alkenes with high yield and Faradaic efficiency remains technically challenging because of kinetically favorable hydrogen evolution reaction and over-hydrogenation.
Linghu Meng, Cheng-Wei Kao, Zhen Wang, Jun Ma, Peifeng Huang, Nan Zhao, Xin Zheng, Ming Peng, Ying-Rui Lu, Yongwen Tan   +9 more
doaj   +1 more source

Technology and Industrialization Progress on Methanol Synthesis from Carbon Dioxide and Hydrogen

南方能源建设, 2020
[Introduction] Carbon dioxide hydrogenation to methanol is one of the important pathways to realize the large-scale utilization of carbon dioxide and it will favor the development of CCUS industrial chain. [Method] Thermodynamic characteristics, catalyst
LIN Haizhou, LUO Zhibin, PEI Aiguo, YANG Hui, WANG Xiaobo   +4 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Novel Nanomaterials for Hydrogen Production and Storage: Evaluating the Futurity of Graphene/Graphene Composites in Hydrogen Energy [PDF]

, 2022
Ahmed Hussain Jawhari
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source