Results 71 to 80 of about 97,085 (317)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Homogeneous palladium-catalyzed asymmetric hydrogenation
, 2013 The transition metal catalyzed asymmetric hydrogenation of unsaturated compounds arguably presents one of the most attractive methods for the synthesis of chiral compounds.
Duan, Ying +4 more
core +2 more sources
"Emulsifier-regulated synthesis of nitrile rubber and its catalytic hydrogenation in emulsion"
Hecheng xiangjiao gongyeThe primary challenge in emulsion hydrogenation resides in maintaining emulsion stability under specific temperature and pressure conditions. This study proposed a strategy involving the incorporation of emulsifiers during the hydrogenation process to ...
GUO Zong-lei1 a, YU Ming-ming2, LI Yan-yan1 b, WANG Hui1 a, WANG Cheng-dong1 a
doaj +1 more source
Hydrogen microscopy – Distribution of hydrogen in buckled niobium hydrogen thin films
International Journal of Hydrogen Energy, 2013 Abstract Hydrogen absorption in thin metal films clamped to rigid substrates results in mechanical stress that changes the hydrogen's chemical potential by ΔμH(σ) = −1.124σ kJ/molH for σ measured in [GPa]. In this paper we show that local stress relaxation by the detachment of niobium hydrogen thin films from the substrate affects the chemical ...
Wagner, Stefan +6 more
openaire +3 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Developments in the hydrogenation of challenging substrates utilising transition metal complexes
, 2014 This thesis describes the developments of new protocols for the hydrogenation of challenging substrates. Three specific substrates were highlighted for study after an initial review of the literature; benzofurans, esters and bulky ketones.
Ian Carpenter, Carpenter, Ian
core
Atomic Three-Dimensional Investigations of Pd Nanocatalysts for Acetylene Semi-hydrogenation
, 2023 Deciphering the three-dimensional (3D) insight into nanocatalyst surfaces at the atomic level is crucial to understanding catalytic reaction mechanisms and developing high-performance catalysts.
Tianyi Li (111582) +14 more
core +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Development of catalysts for asymmetric hydrogenation [PDF]
The application of tetradentate aminoalcohol ligands to the KOtBu-catalysed hydrogenation of benzophenone has been studied. Hydrogenation was found to proceed via a transfer hydrogenation process with the ligands acting as hydrogen donors.
Jolley, Katherine E.
core