Results 191 to 200 of about 272,012 (351)

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2025 Update

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Thiopurine methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) are key enzymes that catabolize thiopurines. Decreased or no‐function alleles in TPMT and NUDT15 are associated with reduced or no enzyme activity and predictive of pronounced adverse effects, including severe myelosuppression, that may occur among individuals treated with standard ...
Maud Maillard   +18 more
wiley   +1 more source

The Topology of the Substrate Binding Clefts of Glycosyl Hydrolase Family 10 Xylanases Are Not Conserved [PDF]

open access: hybrid, 1998
Simon J. Charnock   +7 more
openalex   +1 more source

Increased levels of two distinct elastase-like hydrolases in plasma during septicemia [PDF]

open access: yes, 1983
Duswald, Karl-Heimo   +4 more
core   +1 more source

Selective Modification of the Product Profile of Biocatalytic Hydrolyzed PET via Product‐Specific Medium Engineering

open access: yesChemSusChem, Volume 18, Issue 6, March 15, 2025.
The product profile of enzymatically hydrolyzed PET can be modified by medium engineering and thereby adapted to a desired product. TPA, MHET or BHET can be forced as the predominant product using a basic pH (blue), 25 % ethylene glycol (EG) and IsPETasewt (green) or ≥25 % EG and LCCICCG (pink), respectively.
Tobias Heinks   +8 more
wiley   +1 more source

Chemoproteomic Profiling of Gut Microbiota-Associated Bile Salt Hydrolase Activity

open access: diamond, 2019
Bibudha Parasar   +5 more
openalex   +1 more source

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