Results 191 to 200 of about 297,801 (378)

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

Proceedings of the National Academy of Sciences of the United States of America, 2001
B. Cravatt, K. Demarest, M. Patricelli, M. Bracey, Dan K. Giang, B. Martin, A. Lichtman   +6 more
semanticscholar   +1 more source

Biochemical Characterization of Multimodular Xylanolytic Carbohydrate Esterases from the Marine Bacterium Flavimarina sp. Hel_I_48

ChemBioChem, EarlyView.
Multimodular carbohydrate‐active enzymes often combine different catalytic activities for efficient polysaccharide degradation. In this work, the structural and functional characterization of three multimodular xylan‐targeting esterases, Fl6, Fll1 and Fll4 from Flavimarina sp. Hel_I_48, are presented.
Michelle Teune, Thorben Döhler, Daniel Bartosik, Thomas Schweder, Uwe T. Bornscheuer   +4 more
wiley   +1 more source

Functional sizes of hepatic enzymes of cholesteryl ester metabolism determined by radiation inactivation.

Journal of Lipid Research, 1994
Cellular cholesteryl ester metabolism is regulated largely by the balance between intracellular esterification catalyzed by acyl-CoA:cholesterol acyltransferase and cholesteryl ester hydrolysis catalyzed by the cholesteryl ester hydrolases.
S.K Erickson, S.R Lear, M.J McCreery
doaj  

Glycyl-l-leucine hydrolase, a versatile ‘master’ dipeptidase from monkey small intestine [PDF]

, 1973
Manjusri Das, A.N. Radhakrishnan
openalex   +1 more source

Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy

Nature, 2017
Jiong Hu, Sarah Dziumbla, Ji-hong Lin, Sofia-Iris Bibli, S. Zukunft, J. Mos, K. Awwad, Timo Frömel, A. Jungmann, K. Devraj, Zhixing Cheng, Liya Wang, S. Fauser, C. Eberhart, Akrit Sodhi, B. Hammock, S. Liebner, O. Müller, C. Glaubitz, H. Hammes, R. Popp, I. Fleming   +21 more
semanticscholar   +1 more source

Exploring the Stability and Substrate Profile of Transaminase from Silicibacter pomeroyi with Ancestral Sequence Reconstruction

ChemBioChem, EarlyView.
This study describes the successful identification of ancestral sequences N50 and N49, which have a longer half‐life of approximately four and two times the wild‐type Sp‐amine transaminase, respectively.. This approach effectively enhances the thermal stability of the transaminase.
Luyao Zhao, Bhu‐Bhud Thongrakon, Trishnamoni Gautom, Viktor Sahlberg, Per Berglund   +4 more
wiley   +1 more source

Distribution of the Activity of Various Hydrolases, Transaminases, and Glutamic Dehydrogenase in the Digestive Tracts of Fed and Fasted Rats

, 1967
Lichu Hsu, H. Tarver
openalex   +1 more source

Acetyl‐CoA Hydrolase; Activity, Regulation and Physiological, Significance of the Enzyme in Brown Adipose Tissue from Hamster [PDF]

, 1976
Vibeke Bernson
openalex   +1 more source

Diversity of ThDP‐Dependent Enzymes Forming Chiral Tertiary Alcohols

ChemBioChem, EarlyView.
Chiral tertiary alcohols are widespread in nature and bioactive compounds; however, their asymmetric synthesis faces several challenges. This review outlines the toolbox of ThDP‐dependent enzymes able to produce tertiary alcohols through the formation of CC bond formation using ketones as acceptor substrates. Herein, the substrate scope, the diversity
Daniela Bjarnesen, Lucrezia Lanza, Francesco Presini, Pier Paolo Giovannini, Michael Müller   +4 more
wiley   +1 more source

Cholesteryl ester hydrolase activity is abolished in HSL macrophages but unchanged in macrophages lacking KIAA1363[S]

Journal of Lipid Research, 2010
Cholesteryl ester (CE) accumulation in macrophages represents a crucial event during foam cell formation, a hallmark of atherogenesis. Here we investigated the role of two previously described CE hydrolases, hormone-sensitive lipase (HSL) and KIAA1363 ...
Marlene Buchebner, Thomas Pfeifer, Nora Rathke, Prakash G. Chandak, Achim Lass, Renate Schreiber, Adelheid Kratzer, Robert Zimmermann, Wolfgang Sattler, Harald Koefeler, Eleonore Fröhlich, Gerhard M. Kostner, Ruth Birner-Gruenberger, Kyle P. Chiang, Guenter Haemmerle, Rudolf Zechner, Sanja Levak-Frank, Benjamin Cravatt, Dagmar Kratky   +18 more
doaj