Recent advances in glutarimide chemistry for cereblon-mediated targeted protein degradation: developments in synthesis and diversification. [PDF]
RSC Med ChemBa X +3 more
europepmc +1 more source
Second step of hydrolytic dehalogenation in haloalkane dehalogenase investigated by QM/MM methods
Proteins: Structure, Function and Bioinformatics, 2008 AbstractMechanistic studies on the hydrolytic dehalogenation catalyzed by haloalkane dehalogenases are of importance for environmental and industrial applications. Here, Car‐Parrinello (CP) and ONIOM hybrid quantum‐mechanical/molecular mechanics (QM/MM) are used investigate the second reaction step of the catalytic cycle, which comprises a general base‐
Michal Otyepka +2 more
exaly +6 more sources
Novel enzymic hydrolytic dehalogenation of a chlorinated aromatic
Science, 1991 Microbial enzyme systems may be used in the biodegradation of persistent environmental pollutants. The three polypeptide components of one such system, the 4-chlorobenzoate dehalogenase system, have been isolated, and the chemical steps of the 4-hydroxybenzoate-forming reaction that they catalyze have been identified.
Patricia C Babbitt +2 more
exaly +5 more sources
Syntheses of marine ochtodane antifeedants via hydrolytic dehalogenation
Tetrahedron Letters, 1985 Abstract The syntheses of five naturally occurring antifeedants of the ochtodane ring system (1-ethyl-3,3-dimethylcyclohexane), previously isolated from the marine red alga Ochtodes crockeri , are reported. A key synthetic step involves the hydrolytic debromination of 6-bromo-1,4-ochtodien-3-ol.
Zegarski Joseph, Bruce M. Howard
exaly +3 more sources
Role of reduced flavin in dehalogenation reactions
Archives of Biochemistry and Biophysics, 2021 Halogenated organic compounds are extensively used in the cosmetic, pharmaceutical, and chemical industries. Several naturally occurring halogen-containing natural products are also produced, mainly by marine organisms.
Pablo Sobrado
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Hydrolytic dehalogenation of the chlorothalonil isomer o-tetrachlorophthalonitrile by Pseudochrobactrum sp. BSQ-1 [PDF]
International Biodeterioration and Biodegradation, 2016 Abstract Microbial dehalogenation plays key roles in the biodegradation and detoxification of halogenated aromatics. Although the hydrolytic dehalogenation of halogenated aliphatic hydrocarbons and carboxylic acids has been extensively studied, there are few reports on the hydrolytic dehalogenation of halogenated aromatics. In this study, the aerobic
Shunpeng Li, Jiandong Jiang
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Computer modelling of microbial hydrolytic dehalogenation
Pure and Applied Chemistry, 1998Abstract
Jiří Damborsky
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Identification of genes coding for hydrolytic dehalogenation in the metagenome derived from a denitrifying 4-chlorobenzoate degrading consortium [PDF]
FEMS Microbiology Letters, 2008 A metagenomic approach was taken to investigate the genetic basis for the ability of an anaerobic consortium to grow on either 4-chlorobenzoate or 4-bromobenzoate under denitrifying conditions. Degenerate PCR primers were designed for the family of 4-chlorobenzoyl-CoA dehalogenase genes.
Jong-Chan Chae +2 more
exaly +3 more sources
Microbial dehalogenation [PDF]
Current Opinion in Biotechnology, 2001 Novel dehalogenases have been identified recently in various bacteria that utilise halogenated substrates. X-ray studies and sequence analysis have revealed insight into the molecular mechanisms of hydrolytic dehalogenases.
Dick B Janssen, Gerrit J Poelarends
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