Results 101 to 110 of about 21,152 (225)

Epigenetic polypharmacology: from combination therapy to multitargeted drugs [PDF]

, 2016
The modern drug discovery process has largely focused its attention in the so-called magic bullets, single chemical entities that exhibit high selectivity and potency for a particular target.
A Anighoro, A Dey, A Ganesan, A Mai, A Nudelman, AF Fliri, B Al-Lazikani, B Knoechel, B Meunier, BC Smith, BC Smith, BC Smith, BE Gryder, C Choudhary, C Corminboeuf, C Liu, C Qian, C Tang, C Yu, C Zwergel, C-W Chen, CM Fillmore, CM Grozinger, CY Fong, D Bixby, D Gallenkamp, D Matei, D Passarella, D Rotili, D Sharma, DA Mele, E Bicaku, E Borretto, E Nicodeme, F Sun, F-W Peng, G Zhang, G-L Chen, GE Winter, GL Verdine, H Patel, HS Bandukwala, HS Takhar, J Fischer, J Lu, J Schneider, J Zhao, J Zuber, J-B Chen, J-F Couture, J-PJ Issa, JC Culhane, JL Avalos, JM Burg, JS Kirk, K Agger, K Chen, K K-p, K Pruitt, K Zhao, KB Daniel, KT Thurn, L Chen, L Chen, LK Gediya, M Buchwald, M De los Santos, M Yang, M Zuo, MA Dawson, MA Dawson, MA Park, MB Poulin, MC Chen, MJ Keiser, MM Singh, MS Finnin, N Geva-Zatorsky, OW Rokhlin, P Anand, P Bamborough, P Filippakopoulos, P Hu, P Hu, P Jones, P Rathert, PA Marks, PK Mazur, PN Munster, Q Wang, R Anand, R Morphy, R Morphy, R Nimmanapalli, R Pereira, R Pili, R Álvarez, RA Copeland, RA Juergens, RL Momparler, S Daujat, S Klimasauskas, S Mahboobi, S Mahboobi, S Zhao, SC Hodawadekar, SJ Atkinson, SS Ng, T Beckers, T Finkel, T Kokkola, T Qiu, T Vaissiere, T-G Lee, TH Luu, TJ Galloway, TM Pitts, W Guerrant, WF Hawse, X Cai, X Cheng, X Sun, X Zhang, Y Ling, Y Zhang, Z Chen   +125 more
core   +1 more source

Novel Hydroxamic Acids Containing Aryl-Substituted 1,2,4- or 1,3,4-Oxadiazole Backbones and an Investigation of Their Antibiotic Potentiation Activity. [PDF]

Int J Mol Sci, 2023
Zhukovets AA, Chernyshov VV, Al'mukhametov AZ, Seregina TA, Revtovich SV, Kasatkina MA, Isakova YE, Kulikova VV, Morozova EA, Cherkasova AI, Mannanov TA, Anashkina AA, Solyev PN, Mitkevich VA, Ivanov RA.   +14 more
europepmc   +1 more source

Enzymatic Synthesis and Application of Palm Oil-Based Fatty Hydroxamic Acids [PDF]

, 2004
Fatty hydroxamic acids (FHA) have been successfully synthesized from palm oils by a one-step lipase catalyzed reaction. Conversion of palm oils into the FHA was carried out by treating the substrate with hydroxylamine at 300C and neutral pH for 30 h ...
Suhendra, Dedy
core  

Cobalt complexes with tripodal ligands: implications for the design of drug chaperones [PDF]

, 2012
Extensive research is currently being conducted into metal complexes that can selectively deliver cytotoxins to hypoxic regions in tumours. The development of pharmacologically suitable agents requires an understanding of appropriate ligand–metal systems
Bonnitcha, Paul D., Clegg, Jack K., Hambley, Trevor W., Hocking, Rosalie K., Kim, Byung J., Neville, Suzanne M., Turner, Peter   +6 more
core   +1 more source

Hydroxamic Acids Containing a Bicyclic Pinane Backbone as Epigenetic and Metabolic Regulators: Synergizing Agents to Overcome Cisplatin Resistance. [PDF]

Cancers (Basel), 2023
Aleksandrova Y, Munkuev A, Mozhaitsev E, Suslov E, Volcho K, Salakhutdinov N, Neganova M.   +6 more
europepmc   +1 more source

Synthesis and Evaluation of Cytotoxic Activity of 2-Aryl-2-(3-Indolyl)Propionic Acid Derivatives

Organics
2-Aryl-2-(3-indolyl)acetohydroxamic acids have emerged as promising antitumor agents; however, their poor pharmacokinetic profile remains a significant drawback.
Alexander V. Aksenov, Nicolai A. Aksenov, Nikolai A. Arutiunov, Dmitrii A. Aksenov, Anna M. Zatsepilina, Daria I. Murashkina, Maksim O. Shcheglov, Sergei N. Ovcharov   +7 more
doaj   +1 more source

Antimycobacterial Activities of Hydroxamic Acids and Their Iron(II/III), Nickel(II), Copper(II) and Zinc(II) Complexes. [PDF]

Microorganisms, 2023
Yang D, Zhang Y, Sow IS, Liang H, El Manssouri N, Gelbcke M, Dong L, Chen G, Dufrasne F, Fontaine V, Li R.   +10 more
europepmc   +1 more source

Multitarget Drugs: an Epigenetic Epiphany [PDF]

, 2016
Epigenetics refers to changes in a biological phenotype that are not due to an underlying change in genotype. In eukaryotes, epigenetics involves a set of chemical modifications of the DNA and the histone proteins in nucleosomes.
Atkinson, Baell, Baud, Beckers, Bentley, Blagodatski, Borretto, Bowman, Brand, Burg, Cai, Chen, Chen, Chen, Chen, Ciceri, Dancy, Deans, Fahy, Filippakopoulos, Finley, Fischer, Fuhrmann, Galloway, Gjertsen, Griffith, Guerrant, Guerrant, Hantschel, He, Huang, Hui, Hurley, Jing, Kaniskan, Kingston, Ko, Kortüm, Kozikowski, Lamblin, Lan, Ling, Liu, Lu, Lu, Maes, Mahboobi, Mahboobi, Mai, McGinty, McPherson, Micelli, Moore, Mottamal, Pachaiyappan, Pastor, Patel, Pereira, Pińa, Qian, Rask-Andersen, Rose, Rothbart, Rotili, Saijo, Saijo, Samatar, Schapira, Suganuma, Tavera-Mendoza, Villalba, Wagner, Winter, Wright, Yu, Yuan, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zheng, Zuo, Álvarez   +84 more
core   +1 more source

Elaboration of the Effective Multi-Target Therapeutic Platform for the Treatment of Alzheimer's Disease Based on Novel Monoterpene-Derived Hydroxamic Acids. [PDF]

Int J Mol Sci, 2023
Aleksandrova Y, Munkuev A, Mozhaitsev E, Suslov E, Tsypyshev D, Chaprov K, Begunov R, Volcho K, Salakhutdinov N, Neganova M.   +9 more
europepmc   +1 more source

Synthesis of elastomers for use with liquid fluorine Final report [PDF]

Synthesis and chemical properties of elastomeric polymers resistant to effects of fluorine, oxygen difluoride, nitrogen tetroxide, and similar ...
Brown, H. C., Mukherjee, A. R.
core   +1 more source