Results 71 to 80 of about 7,346 (216)
Causes of and diagnostic approach to methylmalonic acidurias [PDF]
, 2018 Summary: Several mutant genetic classes that cause isolated methylmalonic acidurias (MMAuria) are known based on biochemical, enzymatic and genetic complementation analysis. The mut0 and mut− defects result from deficiency of MMCoA mutase apoenzyme which
Baumgartner, M., Fowler, B., Leonard, J.
core
Drug-therapy networks and the predictions of novel drug targets [PDF]
, 2008 Recently, a number of drug-therapy, disease, drug, and drug-target networks have been introduced. Here we suggest novel methods for network-based prediction of novel drug targets and for improvement of drug efficiency by analysing the effects of drugs on
Csermely, Peter +2 more
core +3 more sources
Catheterization and Cardiovascular Interventions, Volume 106, Issue 3, Page 1740-1745, September 1, 2025.ABSTRACT Vasoplegic syndrome (VS) is a common complication after cardiac surgery with cardiopulmonary bypass (CPB). The main pathophysiology mechanism of VS includes a systemic inflammatory response syndrome due to surgical trauma, release of pro‐inflammatory mediators caused by blood contact with foreign surfaces of heart‐lung machine (pump and tubing)
Matteo Lucchelli +3 more
wiley +1 more source
Cyanide intoxication by apricot kernels: A case report and literature review
Emergency Care Journal, 2019 Acute cyanide intoxication is a serious healthcare problem due to its potentially life threatening and fatal toxic effects. Ingestion of cyanide containing foods is an important source of cyanide poisoning and apricot kernels contain significant amounts ...
Faruk Ekinci +3 more
doaj +1 more source
Journal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.ABSTRACT Cobalamin (vitamin B12) is an essential cofactor for two human enzymes, methionine synthase and methylmalonyl‐CoA mutase. Inborn errors of cobalamin metabolism (IECMs) are inherited genetic defects resulting in improper transport, modification, or utilization of cobalamin and include inherited methylmalonic acidurias, a group of IECMs most ...
Almut Heinken +5 more
wiley +1 more source
Microbial demethylation of dimethylsulfoniopropionate and methylthiopropionate [PDF]
, 2000 As discussed in chapter 1 , there is an increased interest in the production of certain natural sulfur-containing flavor compounds or flavor precursors.
Jansen, Michael,
core +3 more sources
An integrated perspective on RNA aptamer ligand-recognition models : clearing muddy waters [PDF]
, 2017 Riboswitches are short RNA motifs that sensitively and selectively bind cognate ligands to modulate gene expression. Like protein receptor-ligand pairs, their binding dynamics are traditionally categorized as following one of two paradigmatic mechanisms:
McCluskey, K., Penedo, J. Carlos
core +1 more source
Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning
The FASEB Journal, Volume 39, Issue 12, 30 June 2025.Cyanide is coined “the classic metabolic poison”; however, FDA‐approved cyanide chelators do not counteract cyanide's metabolic damage. Here, we review the mechanisms of cyanide toxicity, with a focus on intermediary metabolism. We present the theory that, within the innate plasticity of the metabolome, there may reside metabolic pathways that can ...
Vik S. Bebarta, Anjali K. Nath
wiley +1 more source
An In Vitro Model of Gastric Inflammation and Treatment with Cobalamin
International Journal of Inflammation, 2017 Pernicious anaemia (PA) is an autoimmune condition where antibodies target intrinsic factor and parietal cells, reducing the patient’s ability to absorb cobalamin promoting atrophic gastritis.
T. R. Elliott, A. L. Guildford
doaj +1 more source
BMC Pediatrics, 2022 Background Transcobalamin deficiency is a rare inborn metabolic disorder, characterized by pancytopenia, megaloblastic anemia, failure to thrive, diarrhea, and psychomotor retardation.
Pongpak Pongphitcha +5 more
doaj +1 more source