ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids [PDF]
Nature, 2022 AbstractBranched fatty acid (FA) esters of hydroxy FAs (HFAs; FAHFAs) are recently discovered lipids that are conserved from yeast to mammals1,2. A subfamily, palmitic acid esters of hydroxy stearic acids (PAHSAs), are anti-inflammatory and anti-diabetic1,3.
Rudolf Zechner +2 more
exaly +4 more sources
Construction of a Library of Fatty Acid Esters of Hydroxy Fatty Acids [PDF]
MoleculesFatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) have emerged as extraordinary bioactive lipids, exhibiting diverse bioactivities, from the enhancement of insulin secretion and the optimization of blood glucose absorption to anti-inflammatory effects ...
Olga G. Mountanea +4 more
doaj +5 more sources
Enantioselective Organocatalysis-Based Synthesis of 3-Hydroxy Fatty Acids and Fatty γ-Lactones [PDF]
Molecules, 2019 3-Hydroxy fatty acids have attracted the interest of researchers, since some of them may interact with free fatty acid receptors more effectively than their non-hydroxylated counterparts and their determination in plasma provides diagnostic information ...
Asimina Bourboula +4 more
doaj +4 more sources
Lipids, fatty acids and hydroxy-fatty acids of Euphausia pacifica. [PDF]
Sci Rep, 2017 AbstractEuphausia pacifica is a good candidate for a resource of marine n-3 PUFA. However, few reports exist of the lipid and fatty acid composition of E. pacifica. To examine the potential of E. pacifica as a resource of marine n-3 PUFA, we analyzed E. pacifica oil. We extracted lipids from E.
Yamada H +8 more
europepmc +4 more sources
Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Are Associated With Diet, BMI, and Age [PDF]
Frontiers in Nutrition, 2021 Background: Fatty acid esters of hydroxy fatty acids (FAHFAs) are a group of fatty acids with potential anti-inflammatory and anti-diabetic effects. The blood levels of FAHFAs and their regulation in humans have hardly been studied.Objective: We aimed to investigate serum FAHFA levels in well-characterized human cohorts, to evaluate associations with ...
Hans Hauner +2 more
exaly +6 more sources
Anti-allergic Hydroxy Fatty Acids from Typhonium blumei Explored through ChemGPS-NP [PDF]
Frontiers in Pharmacology, 2017 Increasing prevalence of allergic diseases with an inadequate variety of treatment drives forward search for new alternative drugs. Fatty acids, abundant in nature, are regarded as important bioactive compounds and powerful nutrients playing an important
Michal Korinek +29 more
doaj +4 more sources
A dataset of branched fatty acid esters of hydroxy fatty acids diversity in foods. [PDF]
Sci Data, 2023 AbstractBranched fatty acid esters of hydroxy fatty acids (FAHFAs) are a class of bioactive lipids that show therapeutic potential for diabetes, anti-cancer and inflammation. These FAHFAs can be obtained through dietary intake, potentially improving human health.
An N +5 more
europepmc +4 more sources
Elucidation of the Role of 3-Hydroxy Fatty Acids in Cryptococcus-amoeba Interactions [PDF]
Frontiers in Microbiology, 2017 We previously reported that 3-hydroxy fatty acids promoted the survival of cryptococcal cells when acted upon by amoebae. To expand on this, the current study sought to explain how these molecules may protect cells.
Olihile M. Sebolai +4 more
doaj +2 more sources
The Metabolomic Characteristics and Dysregulation of Fatty Acid Esters of Hydroxy Fatty Acids in Breast Cancer. [PDF]
Metabolites, 2023 Lipid reprogramming metabolism is crucial for supporting tumor growth in breast cancer and investigating potential tumor biomarkers. Fatty acid esters of hydroxy fatty acids (FAHFAs) are a class of endogenous lipid metabolites with anti-diabetic and anti-inflammatory properties that have been discovered in recent years.
Qin L, An N, Yuan B, Zhu Q, Feng Y.
europepmc +4 more sources
Asymmetric Synthesis of Saturated Hydroxy Fatty Acids and Fatty Acid Esters of Hydroxy Fatty Acids
European Journal of Organic Chemistry, 2019 The recent discovery of a novel class of endogenous lipids, named Fatty Acid esters of Hydroxy Fatty Acids (FAHFAs), that present antidiabetic and anti‐inflammatory activities, has attracted the interest on hydroxy fatty acids (HFAs) and their derivatives.
Maroula G Kokotou, George Kokotos
exaly +3 more sources