Results 61 to 70 of about 1,787 (235)

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source

3D‐Printed Titanium Implants with Bioactive Peptide‐Polysaccharide Scaffolds for Personalized Bone Reconstruction

Advanced Healthcare Materials, EarlyView.
Porous 3D‐printed titanium implants are made bioactive by integration with a supramolecular peptide‐hyaluronic acid nanofibrillar scaffold, without the addition of exogenous cells or growth factors. Uniform filling of the implant architecture promotes vascularized, spatially homogeneous bone regeneration, significantly enhancing osteogenesis throughout
Noam Rattner, Vladimir Perlis, Eran Golden, Ariel Pokhojaev, Rachel Sarig, Itzhak Binderman, Michal Halperin‐Sternfeld, Solomon Dadia, Lihi Adler‐Abramovich   +8 more
wiley   +1 more source

Hydroxyapatites and nano-hydroxyapatites as scaffolds in drug delivery towards efficient bone regeneration: A review

Carbohydrate Polymer Technologies and Applications
Bone regeneration is a complex process that requires materials capable of supporting structural integrity, promoting cell proliferation, and enabling effective drug delivery.
Amir Hatami kaleshtari, Samira Farjaminejad, Melika Hasani, Rosana Farjaminejad, Amin Foroozandeh, Majid Abdouss, Mohammad Hasanzadeh   +6 more
doaj   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source

SILICON RELEASE FROM HYDROXYAPATITES IN WATER AND SIMULATED BODY FLUID

Studia Universitatis Babes-Bolyai Chemia, 2017
Nanostructured hydroxyapatite (HAP) and silicon substituted hydroxyapatites (HAP-Si), with 0.47 and 2.34 wt% Si, were prepared by wet precipitation method.
Oana CADAR, †Petre T. FRANGOPOL, Gheorghe TOMOAIA, Daniel OLTEAN-DAN, Gertrud Alexandra PALTINEAN, Aurora MOCANU, Ossi HOROVITZ, Maria TOMOAIA-COTISEL   +7 more
doaj   +1 more source

Crack Repair in Hydroxyapatite Bioceramics Using an Ultraviolet Ultrafast Laser

Advanced Materials Interfaces, EarlyView.
The study proposes an ultrafast ultraviolet laser approach to repair hidden tooth cracks, which has been preliminarily validated on HAP. Moreover, this technique aims to strengthen the native enamel structure rather than introducing a foreign filling material.
Yan Xue, Kai Zheng, Yang Liao, Jing Cao, Xupeng Yuan, Fusong Yuan, Yuxin Leng   +6 more
wiley   +1 more source

Cytotoxicity of stoichiometric hydroxyapatites with different crystallite sizes

Journal of Asian Ceramic Societies, 2014
Hydroxyapatite (HAp) samples were synthesized by a solution reaction method followed by heat-treatments at three different temperatures. Special attention was given to optimizing the processing parameters to obtain the chemical composition near to the ...
Kazuki Shitara, Hidenobu Murata, Kenji Watanabe, Chie Kojima, Yuki Sumida, Atsutomo Nakamura, Atsushi Nakahira, Isao Tanaka, Katsuyuki Matsunaga   +8 more
doaj   +1 more source

3D Printing of Highly Dense and Translucent Zirconia Parts for Dental Applications: Effect of Filament Overlapping

Advanced Materials Technologies, EarlyView.
This study formulated a 5Y‐PSZ zirconia paste for extrusion‐based additive manufacturing via direct ink writing, producing dense ceramic structures for dental applications. A colloidal approach with 47 vol% nanometric powder and tailored additives optimized rheology and printability.
Juliana de Freitas Gouveia Silva, Manuel Fellipe Rodrigues Pais Alves, Ana Carolina da Silva, Tiago Moreira Bastos Campos, Renata Marques De Melo, Susana Maria Henriques Olhero   +5 more
wiley   +1 more source

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, EarlyView.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source