Results 91 to 100 of about 1,972 (243)

Protodesnitazene: The identification and tissue distribution of a new nitazene

Journal of Forensic Sciences, EarlyView.
Abstract Multiple new analogues from the 2‐benzyl benzimidazole or “nitazene” class of drugs have emerged on the drug market in recent years. Nitazenes are highly potent μ‐opioid receptor agonists that present a substantial public health concern due to their elevated risk of severe toxicity in overdose and their significant potential for misuse.
Andrew Griffiths, Nathan Milne, Michelle Johnston, Karen Blakey, Rogan Scott   +4 more
wiley   +1 more source

Comparing clinical laboratory beta‐hydroxybutyrate testing of vitreous humor against toxicological blood analyses in ketoacidosis deaths

Journal of Forensic Sciences, EarlyView.
Abstract Beta‐hydroxybutyrate (BHB) is used in investigations to detect ketoacidotic states. Standard chromatographic methods of analysis of blood have traditionally been used to assess BHB levels. More recently, vitreous humor has been an alternative matrix/body fluid in clinical laboratory testing.
Quinn Basso, Jacqueline Parai, Betty L. C. Chow, Christopher Milroy   +3 more
wiley   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

Aging markers in human urine: A comprehensive, non‐targeted LC‐MS study [PDF]

Metabolites in human biofluids document the physiological status of individuals. We conducted comprehensive, non‐targeted, non‐invasive metabolomic analysis of urine from 27 healthy human subjects, comprising 13 young adults (30 ± 3 years) and 14 seniors
Teruya, Takayuki, Yanagida, Mitsuhiro, Goga, Haruhisa   +2 more
core   +1 more source

Gut Microbiota of Gray Snub‐Nosed Monkeys: Adaptation to Seasonal Variations Through Energy Compensation and Thermogenesis

Integrative Zoology, EarlyView.
Based on metagenome‐assembled genomes (MAGs), the gut microbiota of the gray snub‐nosed monkeys recovered 1229 non‐redundant MAGs. The gut microbiota showed an enhanced capacity to produce energy substrates with increased conversion activity of these substrates during winter.
Yue Sun, Mingyi Zhang, Xiaochen Wang, Xiaolong Huang, Yanze Yu, Huijuan Pan, Haibo Li, Lei Shi, Wei Yang, Chen Zhang, Bo Ding, Xun Liu, Jianfeng Li, Changjiang Qian, Boxing Cheng, Chao Zhang, Jingcheng Ran, Ming Li   +17 more
wiley   +1 more source

Accidental overdose admissions and premature death: A large population‐based data‐linkage cohort study in New South Wales, Australia (PAVLOVA 4)

Addiction, EarlyView.
Abstract Background and aims People with substance use disorders have reduced life‐expectancy; however, risks of premature death from injuries and natural causes following an accidental overdose are not well characterised. This study aimed to estimate risk of premature death (by cause and over time), and disease burden following hospitalised accidental
Firouzeh Noghrehchi, Rose Cairns, Darren M. Roberts, Kirsten C. Morley, Paul S. Haber, Nicholas A. Buckley   +5 more
wiley   +1 more source

Methylenedioxymethamphetamine (MDMA)‐related fatal poisoning in Australia, 2016 to 2025: Trends, characteristics and toxicology

Addiction, EarlyView.
Abstract Aims To determine: (1) Population rates of fatal methylenedioxymethamphetamine (MDMA)‐related poisoning over the period 2016–2023, years with high closure rates in the National Coronial Information System (NDIS); (2) the case characteristics of known cases of fatal MDMA‐related poisoning, 2016–2025; and (3) whether there have been changes in ...
Shane Darke, Johan Duflou, Agata Chrzanowska, Michael Farrell, Julia Lappin, Amy Peacock   +5 more
wiley   +1 more source

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source

Naturally coloured poly(3‐hydroxybutyrate)

Coloration Technology, EarlyView.
Abstract This study reports an innovative approach for producing intrinsically coloured poly(3‐hydroxybutyrate) [P(3HB)] films by incorporating natural dyes—turmeric, paprika, annatto, beetroot and hibiscus—directly into the fermentation medium of Ralstonia solanacearum RS.
Maria Luiza de Oliveira Zanini, Ketnen Rieffel Das Chagas, Camila Rios Piecha, Andressa Baptista Nörnberg, André Ricardo Fajardo, Patrícia Silva Diaz   +5 more
wiley   +1 more source

Prurigo Pigmentosa – an increasingly diagnosed dermatological condition associated with ketogenic diet

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
SUMMARY Prurigo pigmentosa (PP) is a rare inflammatory dermatosis, clinically characterized by intensely pruritic, erythematous papules and papulovesicles, with reticular hyperpigmentation upon healing. We herein report four cases in adults of different ethnic backgrounds, in which the disease was associated with ketogenic metabolic states due to ...
Antigona Aliu, Milan Vidakovic, Marcel Krauß, Julia Hyun, Frank Oellig, Thilo Gambichler, Valentina Laura Müller, Alexander Kreuter   +7 more
wiley   +1 more source