Results 81 to 90 of about 285 (209)
Can Small Molecules Provide Clues on Disease Progression in Cerebrospinal Fluid from Mild Cognitive Impairment and Alzheimer’s Disease Patients? [PDF]
Alzheimer’s Disease (AD) is a complex and multifactorial neurodegenerative disease, which is currently diagnosed via clinical symptoms and non-specific biomarkers (such as Aβ1-42, t-Tau, and p-Tau) measured in cerebrospinal fluid (CSF), which alone do ...
Leonid, Zaslavsky +7 more
core +2 more sources
Integrative Zoology, EarlyView.High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang +6 more
wiley +1 more source
Integrative Zoology, EarlyView.Based on metagenome‐assembled genomes (MAGs), the gut microbiota of the gray snub‐nosed monkeys recovered 1229 non‐redundant MAGs. The gut microbiota showed an enhanced capacity to produce energy substrates with increased conversion activity of these substrates during winter.
Yue Sun +17 more
wiley +1 more source
What anabolic–androgenic steroids reveal about the limits of current harm reduction models
Addiction, EarlyView.Abstract Background Harm reduction has largely been shaped by responses to psychoactive drug use where the most urgent harms are acute. These models focus on overdose, blood‐borne viruses, and rapid‐onset toxicity related harms. When applied wholesale to anabolic–androgenic steroids (AAS), they obscure the distinctive pharmacology, consumer typologies,
Timothy Piatkowski +2 more
wiley +1 more source
Addiction, EarlyView.Abstract Aims To determine: (1) Population rates of fatal methylenedioxymethamphetamine (MDMA)‐related poisoning over the period 2016–2023, years with high closure rates in the National Coronial Information System (NDIS); (2) the case characteristics of known cases of fatal MDMA‐related poisoning, 2016–2025; and (3) whether there have been changes in ...
Shane Darke +5 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli +6 more
wiley +1 more source
Naturally coloured poly(3‐hydroxybutyrate)
Coloration Technology, EarlyView.Abstract This study reports an innovative approach for producing intrinsically coloured poly(3‐hydroxybutyrate) [P(3HB)] films by incorporating natural dyes—turmeric, paprika, annatto, beetroot and hibiscus—directly into the fermentation medium of Ralstonia solanacearum RS.
Maria Luiza de Oliveira Zanini +5 more
wiley +1 more source
Polyhydroxyalkanoates (PHAs) production from saponified sunflower oil in mixed cultures under aerobic condition [PDF]
, 2008 A laboratory study was conducted to assess the optimal conditions for polyhyroxyalkanoates (PHA) production using saponified sunflower oil (SO). The system was operated under continuous sequential phase of growth and accumulation conditions.
Ahmad, Mohd. Azlan +3 more
core +1 more source
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.SUMMARY Prurigo pigmentosa (PP) is a rare inflammatory dermatosis, clinically characterized by intensely pruritic, erythematous papules and papulovesicles, with reticular hyperpigmentation upon healing. We herein report four cases in adults of different ethnic backgrounds, in which the disease was associated with ketogenic metabolic states due to ...
Antigona Aliu +7 more
wiley +1 more source