Results 121 to 130 of about 1,823 (170)
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International Journal of Neuropharmacology, 1964
Abstract The author presents a general review of the pharmacology of sodium 4-hydroxybutyrate, the principal elements of which are: (a) very low toxicity, and metabolic application; (b) the hypnotic activity, which does not cause a decrease in the intensity of oxidative processes; (c) the potentiating action on anaesthetics and neuroplegics ...
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Abstract The author presents a general review of the pharmacology of sodium 4-hydroxybutyrate, the principal elements of which are: (a) very low toxicity, and metabolic application; (b) the hypnotic activity, which does not cause a decrease in the intensity of oxidative processes; (c) the potentiating action on anaesthetics and neuroplegics ...
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A potential new metabolite of gamma-hydroxybutyrate: sulfonated gamma-hydroxybutyric acid
International Journal of Legal Medicine, 2015Detection of gamma-hydroxybutyric acid (GHB) became crucial in many clinical and forensic settings due to its increasing use for recreational purposes and drug-facilitated sexual assault. Its narrow window of detection of about 3-12 h in urine represents a major problem. Analogous to ethyl glucuronide, the recently identified GHB-glucuronide exhibits a
Stephanie, Hanisch +2 more
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Biodeuteration of poly(β-hydroxybutyrate)
International Journal of Biological Macromolecules, 1992The formation of poly(beta-hydroxybutyrate), PHB, by Rhodobacter sphaeroides and Alcaligenes eutrophus was studied using the following carbon sources and solvents: (1), acetate in H2O; (2), D3-acetate in H2O; (3), acetate in 90 to 92% D2O; and (4), D3-acetate in 90 to 92% D2O. The growth of Rb.
R A, Gross +6 more
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2009
Abstract Properties of Special Interest Biocompatibility and biodegradability. Biologically produced PHB is a semicrystalline isotactic stereoregular polymer of 100% R configuration that allows a high level of degradability. PHB is obtained by fermentation of bacteria capable of biosynthesizing polyesters as energy storage media.
Isao Noda +2 more
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Abstract Properties of Special Interest Biocompatibility and biodegradability. Biologically produced PHB is a semicrystalline isotactic stereoregular polymer of 100% R configuration that allows a high level of degradability. PHB is obtained by fermentation of bacteria capable of biosynthesizing polyesters as energy storage media.
Isao Noda +2 more
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Gamma hydroxybutyrate is not a GABA agonist
Progress in Neurobiology, 1996Gamma hydroxybutyrate (GHB) is primarily known and used as a relatively specific inhibitor of central DA release. However, it is also widely assumed to be an agonist or prodrug of gamma-aminobutyric acid (GABA) and its central activity has been attributed to an action exerted at GABA receptors.
J J, Feigenbaum, S G, Howard
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Beta-hydroxybutyrate assay does not cross-react with gamma-hydroxybutyrate
Annals of Emergency Medicine, 2002Eran Elinav, MD Zvi Ackerman, MD Nathan P. Gottehrer, MD Samuel N. Heyman, MD ness. On arrival, the patient’s examination revealed hypoventilation and a Glasgow Coma Scale score of 3. He was intubated and mechanically ventilated and recovered within several hours. Serum GHB returned at 336.1 mg/L, urine GHB returned at 5,293.3 mg/L.
Stephen W. Smith +2 more
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γ-hydroxybutyrate as a treatment for alcoholism
The Lancet, 2005-
CAPUTO, FABIO +3 more
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Gamma-hydroxybutyrate – a drug of abuse
Acta Neurologica Scandinavica, 2006Gamma-hydroxybutyrate (GHB) is a drug of abuse that causes euphoria, anxiolysis, and hypnosis. The recent rise in the recreational intake of GHB, as well as its association with 'drug rape', has turned the attention to GHB in acute hospital settings. Acutely admitted GHB intoxicated patients may display various levels of sedation or coma, but may also ...
K R, Drasbek, J, Christensen, K, Jensen
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Gamma-Hydroxybutyrate Abuse and Dependence
2016Item does not contain ...
Noorden, M.S. van +4 more
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Gamma-hydroxybutyrate withdrawal syndrome
Annals of Emergency Medicine, 2001Gamma-hydroxybutyrate (GHB) withdrawal syndrome is increasingly encountered in emergency departments among patients presenting for health care after discontinuing frequent GHB use. This report describes the characteristics, course, and symptoms of this syndrome.A retrospective review of poison center records identified 7 consecutive cases in which ...
J E, Dyer, B, Roth, B A, Hyma
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