Garcinia cambogia (Hydroxycitric Acid) as a Potential Antiobesity Agent [PDF]
JAMA, 1998 Hydroxycitric acid, the active ingredient in the herbal compound Garcinia cambogia, competitively inhibits the extramitochondrial enzyme adenosine triphosphate-citrate (pro-3S)-lyase. As a citrate cleavage enzyme that may play an essential role in de novo lipogenesis inhibition, G cambogia is claimed to lower body weight and reduce fat mass in humans ...
Heymsfield SB +5 more
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In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase. [PDF]
Apoptosis, 2020 Caloric restriction mimetics (CRMs) are promising molecules to prevent age-related diseases as they activate pathways driven by a true caloric restriction.
Baroni MD +5 more
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Hydroxycitric Acid Alleviated Lung Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress and Ferroptosis through the Hif-1α Pathway. [PDF]
Curr Issues Mol Biol, 2023 Lung ischemia-reperfusion injury (LIRI) is a prevalent occurrence in various pulmonary diseases and surgical procedures, including lung resections and transplantation. LIRI can result in systemic hypoxemia and multi-organ failure. Hydroxycitric acid (HCA)
Lu ZL +6 more
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(-)-Hydroxycitric acid reduced fat deposition via regulating lipid metabolism-related gene expression in broiler chickens. [PDF]
Lipids Health Dis, 2016 Han J, Li L, Wang D, Ma H.
europepmc +2 more sources
Hydroxycitric acid ameliorates inflammation and oxidative stress in mouse models of multiple sclerosis. [PDF]
Neural Regen Res, 2016 Hydroxycitric acid (HCA) is derived primarily from the Garcinia plant and is widely used for its anti-inflammatory effects. Multiple sclerosis can cause an inflammatory demyelination and axonal damage.
Goudarzvand M +11 more
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High-Expansion Natural Composite Films for Controlled Delivery of Hydroxycitric Acid in Obesity Therapy. [PDF]
Polymers (Basel)Expandable films represent a promising gastroretentive drug delivery system, offering prolonged gastric retention and sustained drug release features particularly advantageous for obesity treatment.
Fungfoung K +3 more
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Hibiscus acid and hydroxycitric acid dimethyl esters from Hibiscus flowers induce production of dithiolopyrrolone antibiotics by Streptomyces Strain MBN2-2. [PDF]
Nat Prod BioprospectPlants and microbes are closely associated with each other in their ecological niches. Much has been studied about plant–microbe interactions, but little is known about the effect of phytochemicals on microbes at the molecular level.
Sumang FA +3 more
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Production of Hydroxycitric Acid by Microorganisms
Bioscience, Biotechnology, and Biochemistry, 2005 Hydroxycitric acid (HCA) is a major acid component of the tropical plants Garcinia cambogia and Hibiscus subdariffa. (2S,3S)-HCA from G. cambogia was shown to be a potent inhibitor of ATP citrate lyase (EC4.1.3.8), which catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA. (2S,3R)-HCA from H.
HIDA, Hiroyuki +2 more
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Biological effect of hydroxycitric acid within a Garcinia Cambogia extract on the nutrient metabolism [PDF]
, 2019 ArticleAmong plant supplements, which once included in a food regimen, induce a favorable evolution in persons seeking to lose some weight, Garcinia cambogia fruit containing hydroxycitric acid deserves close attention.
Baluyan, Kh.A. +5 more
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Isolation and Characterisation of Hydroxy Citric Acid from the Fruit Extract Graciana Cambogia [PDF]
, 2023 The Garcinia cambogia fruit rind, often referred to as Garcinia gummi-gutta, has long been used as a flavoring and as an anti-inflammatory, particularly in the treatment of obesity. Many active chemical ingredients, including terpenoids and hydroxycitric
Chetan Ghulaxe, Laxmikant N Barde
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