Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using <sup>1</sup>H NMR spectroscopy. [PDF]
FEBS Open BioWe investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Davies EC +3 more
europepmc +2 more sources
No evidence demonstrating hepatotoxicity associated with hydroxycitric acid [PDF]
World Journal of Gastroenterology, 2009 Although a number of cases of hepatotoxicity are associated with the use of Hydroxycut weight management products, it has been alleged that their effects are primarily due to the presence of hydroxycitric acid (HCA, as Super CitriMax) in the formulations.
Sidney J Stohs +6 more
europepmc +3 more sources
Hydroxycitric acid prevents hyperoxaluric-induced nephrolithiasis and oxidative stress via activation of the Nrf2/Keap1 signaling pathway. [PDF]
Cell Cycle, 2023 Nephrolithiasis is a common and frequently-occurring disease in the urinary system with high recurrence. The present study aimed to explore the protective effect and underlying mechanism of hydroxycitric acid (HCA) in hyperoxaluria-induced ...
Yang B +6 more
europepmc +2 more sources
Effects of Hydroxycitric Acid Supplementation on Body Composition, Obesity Indices, Appetite, Leptin, and Adiponectin of Women with NAFLD on a Calorie-Restricted Diet [PDF]
International Journal of Clinical Practice, 2023 Background. This trial assessed the effects of a calorie-restricted diet (CRD) with hydroxycitric acid (HCA) supplementation on appetite-regulating hormones, obesity indices, body composition, and appetite in women with nonalcoholic fatty liver disease ...
Helda Tutunchi +3 more
doaj +2 more sources
High-Expansion Natural Composite Films for Controlled Delivery of Hydroxycitric Acid in Obesity Therapy. [PDF]
Polymers (Basel)Expandable films represent a promising gastroretentive drug delivery system, offering prolonged gastric retention and sustained drug release features particularly advantageous for obesity treatment.
Fungfoung K +3 more
europepmc +2 more sources
In VitroandIn VivoToxicity ofGarciniaor Hydroxycitric Acid: A Review [PDF]
Evidence-Based Complementary and Alternative Medicine, 2012 Obesity is one of the pandemic chronic diseases commonly associated with health disorders such as heart attack, high blood pressure, diabetes or even cancer. Among the current natural products for obesity and weight control,Garciniaor more specifically hydroxycitric acid (HCA) extracted fromGarciniahas been widely used.
Chuah, Li Oon +4 more
europepmc +4 more sources
Comparison of the effects of three different (-)-hydroxycitric acid preparations on food intake in rats [PDF]
Nutrition & Metabolism, 2005 Background Studies on the effects of (-)-hydroxycitric acid (HCA) in humans are controversial. As differences in the HCA preparations may contribute to this apparent discrepancy, the aim of the current study is to compare different HCA-containing ...
Scheurink Anton JW +3 more
doaj +3 more sources
Hydroxycitric acid does not promote inflammation or liver toxicity [PDF]
World Journal of Gastroenterology, 2013 Garcinia cambogia extract (GC) with its active component consisting of hydroxycitric acid (HCA) is widely utilized for weight loss. Various HCA salts are available, including calcium, magnesium, potassium and mixtures of these. Experimentally, these salts exhibit different properties with some, but not all, improving glucose tolerance and blood ...
Dallas L, Clouatre, Harry G, Preuss
openaire +3 more sources
Applicability of <i>Hibiscus sabdariffa</i> L. Extract With Anti-Inflammatory Potential in Human Health: A Review. [PDF]
Food Sci NutrO artigo de revisão explora os potenciais benefícios anti‐inflamatórios do extrato de Hibiscus sabdariffa L. para a saúde humana. O objetivo é fornecer uma análise detalhada das propriedades terapêuticas da planta e sua aplicabilidade no tratamento de condições relacionadas à inflamação. ABSTRACT Studies demonstrate the health benefits of H. sabdariffa
Nogueira da Cruz ACS +10 more
europepmc +2 more sources
A clinical and computational study on anti-obesity effects of hydroxycitric acid [PDF]
RSC Advances, 2019 Hydroxycitric acid (HCA), a major active ingredient ofGarcinia cambogiaextracts, is known to suppress body weight gain and fat synthesis in animals and humans.
Manu Tomar +9 more
openaire +4 more sources