Results 61 to 70 of about 5,905,176 (286)

Blood metabolic fingerprinting of rats, subjected to subchronic lead exposure

Public Health and Toxicology, 2021
Introduction Environmental pollution with heavy metals is vital issue in the present time. Lead, as one of the environmental contaminators, deserves attention due to its applicability in human activity and its xenobiotic character. Methods In this study
Aleksei I. Chemezov, Marina P. Sutunkova, Ilzira A. Minigalieva, Svetlana V. Klinova, Iulia V. Ryabova   +4 more
doaj   +1 more source

Deuterated Arachidonic Acids Library for Regulation of Inflammation and Controlled Synthesis of Eicosanoids: An In Vitro Study

Molecules, 2018
The synthesis of signal lipids, including eicosanoids, is not fully understood, although it is key to the modulation of various inflammatory states.
Dmitry V. Chistyakov, Ivan S. Filimonov, Nadezhda V. Azbukina, Sergei V. Goriainov, Viktor V. Chistyakov, Maksim A. Fomich, Andrei V. Bekish, Vadim V. Shmanai, Marina G. Sergeeva, Mikhail S. Shchepinov   +9 more
doaj   +1 more source

Eicosanoids in Nonalcoholic Fatty Liver Disease (NAFLD) Progression. Do Serum Eicosanoids Profile Correspond with Liver Eicosanoids Content during NAFLD Development and Progression?

Molecules, 2020
Nonalcoholic fatty liver disease (NAFLD) is becoming a major public health problem worldwide. The study aimed to evaluate the concentration of eicosanoids in serum and liver tissue during steatosis progression and to assess whether eicosanoid change ...
Dominika Maciejewska, Arleta Drozd, Karolina Skonieczna-Żydecka, Marta Skórka-Majewicz, Karolina Dec, Karolina Jakubczyk, Anna Pilutin, Ewa Stachowska   +7 more
doaj   +1 more source

Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice [PDF]

, 2014
Lipid composition, particularly membrane unsaturation, has been proposed as being a lifespan determinant, but it is currently unknown whether caloric restriction (CR), an accepted life-extending intervention, affects cellular lipid profiles.
Jové, Mariona, Naudí, Alba, Pamplona, Reinald, Portero-Otín, Manuel, Ramírez-Núñez, Omar, Selman, Colin, Withers, Dominic J.   +6 more
core   +3 more sources

Proliferative effects of insulin and epidermal growth factor on mouse mammary epithelial cells in primary culture. Enhancement by hydroxyeicosatetraenoic acids and synergism with prostaglandin E2.

Journal of Biological Chemistry, 1988
Linoleate metabolism via the cyclooxygenase pathway enhances the proliferation of mammary epithelial cells in serum-free culture in the presence of epidermal growth factor and insulin (Bandyopadhyay, G.K., Imagawa, W., Wallace, D., and Nandi, S. (1987) J.
G. Bandyopadhyay, W. Imagawa, D. Wallace, S. Nandi   +3 more
semanticscholar   +1 more source

Cellular Oxygenation of 12-Hydroxyeicosatetraenoic Acid and 15-Hydroxyeicosatetraenoic Acid by 5-Lipoxygenase Is Stimulated by 5-Lipoxygenase-activating Protein [PDF]

Journal of Biological Chemistry, 1998
It has been proposed that 5-lipoxygenase (5-LO)-activating protein (FLAP) is an arachidonate transfer protein for leukotriene biosynthesis. Using the Spodoptera frugiperda (Sf9) insect cells, we demonstrate that FLAP causes a large stimulation (190-fold) of the conversion of 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) to 5, 12-diHETE when co ...
J A, Mancini, H, Waterman, D, Riendeau
openaire   +2 more sources

N–3 fatty acid deficiency in the rat pineal gland: effects on phospholipid molecular species composition and endogenous levels of melatonin and lipoxygenase products

Journal of Lipid Research, 1998
N–3 essential fatty acid deficiency affects a number of biological and physiological processes. In this study, we investigated the effect of n–3 essential fatty acid status on two key pineal biochemical functions, melatonin production and lipoxygenation,
Hongjian Zhang, Jillonne H. Hamilton, Norman Salem, Jr., Hee-Yong Kim   +3 more
doaj   +1 more source

5-Lipooxygenase Derivatives as Serum Biomarkers of a Successful Dietary Intervention in Patients with NonAlcoholic Fatty Liver Disease

Medicina, 2020
Background: It was previously shown that a bodyweight reduction among patients with nonalcoholic fatty liver (NAFLD) was connected to the lower concentration of arachidonic and linoleic acid derivatives in their blood.
Marcin Banaszczak, Dominika Maciejewska, Arleta Drozd, Karina Ryterska, Dominika Jamioł Milc, Joanna Raszeja-Wyszomirska, Ewa Wunsch, Pedro González-Muniesa, Ewa Stachowska   +8 more
doaj   +1 more source

Arachidonic Acid as a Possible Negative Feedback Inhibitor of Nicotinic Acetylcholine Receptors on Neurons [PDF]

, 1995
Neuronal acetylcholine receptors, being highly permeable to calcium, are likely to regulate calcium-dependent events in neurons. Arachidonic acid is a membrane-permeant second messenger that can be released from membrane phospholipids by phospholipases ...
Berg, Darwin K., Blumenthal, Edward M, Huang, Bo, Vijayaraghavan, Sukumar   +3 more
core   +2 more sources

Regulation of KCa2.3 andendothelium-dependent hyperpolarization (EDH) in the rat middle cerebral artery: the role of lipoxygenase metabolites and isoprostanes [PDF]

, 2014
Background and Purpose. In rat middle cerebral arteries, endothelium-dependent hyperpolarization (EDH) is mediated by activation of calcium-activated potassium(KCa) channels specifically KCa2.3 and KCa3.1.
Campbell, William B, Gauthier, Kathryn M, McNeish, Alister J   +2 more
core   +1 more source