Results 81 to 90 of about 5,905,176 (286)

Plasma oxylipins and unesterified precursor fatty acids are altered by DHA supplementation in pregnancy: Can they help predict risk of preterm birth? [PDF]

, 2019
Oxidized lipids derived from omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids, collectively known as oxylipins, are bioactive signaling molecules that play diverse roles in human health and disease.
Best, Karen, Gibson, Robert A, Horowitz, Mark S, Jensen, Jennifer, Makrides, Maria, Ramsden, Christopher E, Taha, Ameer Y, Yelland, Lisa N, Yuan, Zhi-Xin, Zamora, Daisy   +9 more
core   +2 more sources

Altered Protein Expression of Cardiac CYP2J and Hepatic CYP2C, CYP4A, and CYP4F in a Mouse Model of Type II Diabetes—A Link in the Onset and Development of Cardiovascular Disease?

Pharmaceutics, 2017
Arachidonic acid can be metabolized by cytochrome P450 (CYP450) enzymes in a tissue- and cell-specific manner to generate vasoactive products such as epoxyeicosatrienoic acids (EETs-cardioprotective) and hydroxyeicosatetraenoic acids (HETEs-cardiotoxic).
Benoit Drolet, Sylvie Pilote, Carolanne Gélinas, Alida-Douce Kamaliza, Audrey Blais-Boilard, Jessica Virgili, Dany Patoine, Chantale Simard   +7 more
doaj   +1 more source

Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-Type 12-Lipoxygenase. [PDF]

, 2019
Human platelet ALOX12 (hALOX12 or h12-LOX) has been implicated in a variety of human diseases. The present study investigates the active site of hALOX12 to more thoroughly understand how it positions the substrate and achieves nearly perfect regio- and ...
Aleem, Ansari Mukhtar, Alvarez, Gabriella, Deschamps, Joshua, Holman, Theodore, Jacobson, Matthew P, Kalyanaraman, Chakrapani, Tena, Jennyfer, Tsai, Wan-Chen   +7 more
core   +2 more sources

Variation in the human soluble epoxide hydrolase gene and risk of restenosis after percutaneous coronary intervention [PDF]

, 2009
Background Restenosis represents the major limiting factor for the long-term efficacy of percutaneous coronary intervention (PCI). Several genetic factors involved in the regulation of the vascular system have been described to play a role in the ...
Silke Kullmann, Priska Binner, Kirsten Rackebrandt, Andreas Huge, Georg Haltern, Mark Lankisch, Reiner Füth, Eberhard von Hodenberg, Hans-Peter Bestehorn, Thomas Scheffold, W McBride, DJ Cohen, M Loutfi, R Fattori, S Rosanio, L Gruberg, D Petrovic, PS Monraats, RJ Roman, A Sarkis, WB Campbell, JD Imig, JD Imig, K Node, WB Campbell, F Krotz, BT Larsen, M Spiecker, AA Spector, Z Yu, MJ Corenblum, M Fornage, CJ Sinal, A Luria, X Fang, Q Wei, KP Burdon, CR Lee, M Sandberg, BD Przybyla-Zawislak, HP Bestehorn, PK Srivastava, M Nakatani, RS Schwartz, M Fornage, S Kathiresan   +45 more
core   +1 more source

Arachidonic acid epoxygenase and 12(S)-lipoxygenase: evidence of their concerted involvement in ductus arteriosus constriction to oxygen [PDF]

, 2011
Oxygen promotes closure of the ductus arteriosus at birth. We have previously presented a scheme for oxygen action with a cytochrome P450 (CYP450) hemoprotein and endothelin-1 (ET-1) being, respectively, sensor and effector, and a hypothetical ...
B. Baragatti, F. Coceani
core   +1 more source

Does influenza A infection increase oxidative damage? [PDF]

, 2014
Considerable data implicate oxidative damage in influenza pathogenesis. We examined temporal changes in oxidative damage using accurate biomarkers in an adult cohort with acute influenza infection and their relationships with clinical parameters ...
Halliwell, B, Lee, JCY, Lim, ECH, Loke, WM, Ng, MPE, Quek, AML, Seet, RCS, Yeo, LLL   +7 more
core   +1 more source

20-hydroxyeicosatetraenoic acid, endothelial dysfunction and hypertension

Medicinski glasnik Ljekarske komore Zeničko-dobojskog kantona, 2011
20-hydroxyeicosatrienoic acid (20-HETE) is a metabolite of arachidonic acid formed by the enzymatic activity of cytochrome P450 omega hydroxylases of the 4A and 4F isoform families (CYP 450 4A and 4F). The role of the metabolites of arachidonic acid (AA) formed by cyclooxygenases and lipoxygenases in mediating cardiovascular function have been studied ...
Kunert, Mary Pat, Drenjancevic, Ines
openaire   +2 more sources

Glycerolipid Composition of the Red Macroalga Agarophyton Chilensis and Comparison to the Closely Related Agarophyton Vermiculophyllum Producing Different Types of Eicosanoids

Marine Drugs, 2019
The red macroalga Agarophyton chilensis is a well-known producer of eicosanoids such as hydroxyeicosatetraenoic acids, but the alga produces almost no prostaglandins, unlike the closely related A. vermiculophyllum.
Masaki Honda, Takashi Ishimaru, Yutaka Itabashi, Mikhail Vyssotski   +3 more
doaj   +1 more source

Vascular Endothelial Over-Expression of Human Soluble Epoxide Hydrolase (Tie2-sEH Tr) Attenuates Coronary Reactive Hyperemia in Mice: Role of Oxylipins and ω-Hydroxylases.

PLoS ONE, 2017
Cytochromes P450 metabolize arachidonic acid (AA) into two vasoactive oxylipins with opposing biologic effects: epoxyeicosatrienoic acids (EETs) and omega-(ω)-terminal hydroxyeicosatetraenoic acids (HETEs).
Ahmad Hanif, Matthew L Edin, Darryl C Zeldin, Christophe Morisseau, John R Falck, Mohammed A Nayeem   +5 more
doaj   +1 more source

5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1. [PDF]

, 2018
The reaction of 5 S,15 S-dihydroperoxyeicosatetraenoic acid (5,15-diHpETE) with human 5-lipoxygenase (LOX), human platelet 12-LOX, and human reticulocyte 15-LOX-1 was investigated to determine the reactivity and relative rates of producing lipoxins (LXs).
Freedman, Cody, Green, Abigail R, Holinstat, Michael, Holman, Theodore R, Liu, Benjamin, Tena, Jennyfer, Tourdot, Benjamin E   +6 more
core   +3 more sources