Results 91 to 100 of about 132 (117)
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Does 2-Hydroxyestrone Suppress Prolactin in Women=*
The Journal of Clinical Endocrinology & Metabolism, 1982The catechol estrogen 2-hydroxyestrone was administered iv to six normal women at a dose of 80 µg/h for 4 h. In contrast to previous studies, no suppression of plasma PRL concentrations and no effect on LH or FSH were observed. We found no evidence to suggest that this compound behaves peripherally as anything other than a weak ...
G R, Merriam +3 more
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Radioimmunoassay of 2-Hydroxyestrone in Human Plasma
The Journal of Clinical Endocrinology & Metabolism, 1971ABSTRACT Rabbit anti-2-hydroxyestrone antiserum was obtained using 2-hydroxyestrone coupled to bovine serum albumin as the antigen. A radioimmunoassay procedure for 2-hydroxyestrone utilizing the highly specific antiserum was developed and permitted the measurement of this labile material in body fluids.
I, Yoshizawa, J, Fishman
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Steroids, 1999
The ratio of urinary 2-hydroxyestrone (2-OHE1) to 16alpha-hydroxyestrone (16alpha-OHE1) has been suggested as a potential biomarker for breast cancer risk. We evaluated within-person variability of this biomarker in ten healthy Caucasian women aged 23-58 years. Each study participant was asked to provide an overnight fasting morning urine sample once a
Z, Chen +5 more
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The ratio of urinary 2-hydroxyestrone (2-OHE1) to 16alpha-hydroxyestrone (16alpha-OHE1) has been suggested as a potential biomarker for breast cancer risk. We evaluated within-person variability of this biomarker in ten healthy Caucasian women aged 23-58 years. Each study participant was asked to provide an overnight fasting morning urine sample once a
Z, Chen +5 more
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Simple total synthesis of 18-hydroxyestrone
Tetrahedron Letters, 1981Abstract A simple total synthesis of 18-hydroxyestrone ( 7 ) was carried out by the cycloaddition of o-quinodimethane intermediate. 2-Methoxycarbonyl-3-vinyl-cyclopentanone ( 1 ) was used as the D ring component.
Jiro Tsuji +3 more
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4-hydroxyestrone, isolation and identification in human urine
Steroids, 1980Portions of pregnancy and midcycle urines were submitted to hot acid hydrolysis, extracted with benzene/ethyl acetate and the extracts washed with ascorbic acid buffer. From the remaining organic phase the catecholestrogens were removed with borate buffer and further purified on Sephadex LH-20 columns.
G, Emons +3 more
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ChemInform Abstract: Practical Synthesis of 11α‐Hydroxyestrone.
ChemInform, 1999AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
L. E. Golubovskaya, V. M. Rzheznikov
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Cancer Causes & Control, 2005
Estrogen is metabolized in the body through two mutually exclusive pathways yielding metabolites with different biological activities: the low estrogenic 2-hydroxyestrone (2-OHE1) and the highly estrogenic 16alpha-hydroxyestrone (16alpha-OHE1). The ratio of these metabolites (2/16) may be predictive of risk for developing breast cancer.
Ann T, Bentz +2 more
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Estrogen is metabolized in the body through two mutually exclusive pathways yielding metabolites with different biological activities: the low estrogenic 2-hydroxyestrone (2-OHE1) and the highly estrogenic 16alpha-hydroxyestrone (16alpha-OHE1). The ratio of these metabolites (2/16) may be predictive of risk for developing breast cancer.
Ann T, Bentz +2 more
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Steroids, 1982
The synthesis of [2H8] estradiol, [2H7] estrone, [2H6] 2-hydroxyestrone and [2H6] 4-hydroxyestrone from estrone (as a source) is described. The high isotopical purity renders the labelled compounds as suitable carriers and internal standards for quantitative gas chromatography - mass spectrometry. The content of protonium-form (i.e.
R, Knuppen, O, Haupt, H O, Hoppen
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The synthesis of [2H8] estradiol, [2H7] estrone, [2H6] 2-hydroxyestrone and [2H6] 4-hydroxyestrone from estrone (as a source) is described. The high isotopical purity renders the labelled compounds as suitable carriers and internal standards for quantitative gas chromatography - mass spectrometry. The content of protonium-form (i.e.
R, Knuppen, O, Haupt, H O, Hoppen
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Role of 2-Hydroxyestrone in Estrogen Metabolism
The Journal of Clinical Endocrinology & Metabolism, 1963The importance of 2-hydroxyestrone as a product of the metabolism of estradiol in man is discussed. The substantial losses of this metabolite in the various stages of isolation from urine have been estimated.
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The Journal of Clinical Endocrinology & Metabolism, 1980
Metabolism of estradiol in men with cirrhosis and subjects with systemic lupus erythematosus results in an excessive formation of 16 alpha-hydroxyestrone. Examination of the biological activity of this metabolite showed that it is a potent uterotropic agent and that it exhibits minimal affinity for the human sex hormone-binding globulin.
J, Fishman, C, Martucci
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Metabolism of estradiol in men with cirrhosis and subjects with systemic lupus erythematosus results in an excessive formation of 16 alpha-hydroxyestrone. Examination of the biological activity of this metabolite showed that it is a potent uterotropic agent and that it exhibits minimal affinity for the human sex hormone-binding globulin.
J, Fishman, C, Martucci
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