Results 111 to 120 of about 154 (134)
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Steroids, 1999
The ratio of urinary 2-hydroxyestrone (2-OHE1) to 16alpha-hydroxyestrone (16alpha-OHE1) has been suggested as a potential biomarker for breast cancer risk. We evaluated within-person variability of this biomarker in ten healthy Caucasian women aged 23-58 years. Each study participant was asked to provide an overnight fasting morning urine sample once a
Z, Chen +5 more
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The ratio of urinary 2-hydroxyestrone (2-OHE1) to 16alpha-hydroxyestrone (16alpha-OHE1) has been suggested as a potential biomarker for breast cancer risk. We evaluated within-person variability of this biomarker in ten healthy Caucasian women aged 23-58 years. Each study participant was asked to provide an overnight fasting morning urine sample once a
Z, Chen +5 more
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Simple total synthesis of 18-hydroxyestrone
Tetrahedron Letters, 1981Abstract A simple total synthesis of 18-hydroxyestrone ( 7 ) was carried out by the cycloaddition of o-quinodimethane intermediate. 2-Methoxycarbonyl-3-vinyl-cyclopentanone ( 1 ) was used as the D ring component.
Jiro Tsuji +3 more
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4-hydroxyestrone, isolation and identification in human urine
Steroids, 1980Portions of pregnancy and midcycle urines were submitted to hot acid hydrolysis, extracted with benzene/ethyl acetate and the extracts washed with ascorbic acid buffer. From the remaining organic phase the catecholestrogens were removed with borate buffer and further purified on Sephadex LH-20 columns.
G, Emons +3 more
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ChemInform Abstract: Practical Synthesis of 11α‐Hydroxyestrone.
ChemInform, 1999AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
L. E. Golubovskaya, V. M. Rzheznikov
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Cancer Causes & Control, 2005
Estrogen is metabolized in the body through two mutually exclusive pathways yielding metabolites with different biological activities: the low estrogenic 2-hydroxyestrone (2-OHE1) and the highly estrogenic 16alpha-hydroxyestrone (16alpha-OHE1). The ratio of these metabolites (2/16) may be predictive of risk for developing breast cancer.
Ann T, Bentz +2 more
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Estrogen is metabolized in the body through two mutually exclusive pathways yielding metabolites with different biological activities: the low estrogenic 2-hydroxyestrone (2-OHE1) and the highly estrogenic 16alpha-hydroxyestrone (16alpha-OHE1). The ratio of these metabolites (2/16) may be predictive of risk for developing breast cancer.
Ann T, Bentz +2 more
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Steroids, 1982
The synthesis of [2H8] estradiol, [2H7] estrone, [2H6] 2-hydroxyestrone and [2H6] 4-hydroxyestrone from estrone (as a source) is described. The high isotopical purity renders the labelled compounds as suitable carriers and internal standards for quantitative gas chromatography - mass spectrometry. The content of protonium-form (i.e.
R, Knuppen, O, Haupt, H O, Hoppen
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The synthesis of [2H8] estradiol, [2H7] estrone, [2H6] 2-hydroxyestrone and [2H6] 4-hydroxyestrone from estrone (as a source) is described. The high isotopical purity renders the labelled compounds as suitable carriers and internal standards for quantitative gas chromatography - mass spectrometry. The content of protonium-form (i.e.
R, Knuppen, O, Haupt, H O, Hoppen
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Role of 2-Hydroxyestrone in Estrogen Metabolism
The Journal of Clinical Endocrinology & Metabolism, 1963The importance of 2-hydroxyestrone as a product of the metabolism of estradiol in man is discussed. The substantial losses of this metabolite in the various stages of isolation from urine have been estimated.
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The Journal of Clinical Endocrinology & Metabolism, 1980
Metabolism of estradiol in men with cirrhosis and subjects with systemic lupus erythematosus results in an excessive formation of 16 alpha-hydroxyestrone. Examination of the biological activity of this metabolite showed that it is a potent uterotropic agent and that it exhibits minimal affinity for the human sex hormone-binding globulin.
J, Fishman, C, Martucci
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Metabolism of estradiol in men with cirrhosis and subjects with systemic lupus erythematosus results in an excessive formation of 16 alpha-hydroxyestrone. Examination of the biological activity of this metabolite showed that it is a potent uterotropic agent and that it exhibits minimal affinity for the human sex hormone-binding globulin.
J, Fishman, C, Martucci
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RAPID METABOLIC CLEARANCE OF THE CATECHOL ESTROGEN 2-HYDROXYESTRONE
The Journal of Clinical Endocrinology & Metabolism, 1980The plasma metabolic clearance rate (MCRp) of 2-hydroxyestrone was measured in normal young adults by two methods: infusion of unlabeled 2-OHE1 to equilibrium with radioimmunoassay of plasma 2-OHE1 levels, and infusion of [3H]2-OHE1 to equilibrium with measurement of chromatographically purified plasma [3H]2-OHE1. MCR's were 40--70,000 L/day and 15--50,
G R, Merriam +5 more
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Effective synthesis of a hexacyclic-steroid derivative from 4-hydroxyestrone
Steroids, 2020Several studies have been reported for the preparation of hexacyclic-steroid derivatives; however, some reagents are expensive and require special conditions for handling. In this way, the objective of this study was to synthesize a hexacyclic-steroid derivative from 4-hydroxyestrone. The chemical structure was evaluated through both 1H NMR and 13C NMR
Figueroa-Valverde, Lauro +6 more
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