Results 121 to 130 of about 154 (134)

Increased urinary excretion of 2-hydroxyestrone but not 16alpha-hydroxyestrone in premenopausal women during a soya diet containing isoflavones.

Cancer research, 2000
Asian diets high in soy are associated with lower risk for breast cancer compared with Western diets. Moreover, higher levels of two putative carcinogenic metabolites of 17beta-estradiol, 4- and 16alpha-hydroxyestrogen, and lower amounts of anticarcinogenic metabolites, 2-hydroxyestrogens, have been associated with greater breast cancer risk.
L J, Lu, M, Cree, S, Josyula, M, Nagamani, J J, Grady, K E, Anderson   +5 more
openaire   +2 more sources

The Excretion of 2-Hydroxyestrone During the Menstrual Cycle*

The Journal of Clinical Endocrinology & Metabolism, 1975
A double isotope derivative determination technique was developed to investigate the excretion of 2-hydroxyestrone inhuman menstrual cycle. The method is highly specific, accurate and precise within the range of 0.2-20 nmol 2-hydroxyestrone/20ml of urine.
P, Ball, H P, Gelbke, R, Knuppen
openaire   +2 more sources

2-hydroxyestrone: the 'good' estrogen.

The Journal of endocrinology, 1996
The issue of the role of 2-hydroxyestrone (2-OHE1) in breast cancer has been the subject of considerable controversy as to whether it is carcinogenic or anticarcinogenic. The expanding data base outlined below is most consistent with the conclusion that 2-OHE1 is anticarcinogenic.
H L, Bradlow, N T, Telang, D W, Sepkovic, M P, Osborne   +3 more
openaire   +1 more source

Urinary equol excretion in relation to 2-hydroxyestrone and 16α-hydroxyestrone concentrations: an observational study of young to middle-aged women

The Journal of Steroid Biochemistry and Molecular Biology, 2003
Approximately one-third to one-half of individuals harbor the colonic bacteria that are capable of metabolizing the soy isoflavone daidzein to equol. Results of prior studies suggest beneficial effects of producing equol in relation to breast cancer risk, potentially through effects on endogenous hormones.
Atkinson, C, Skor, HE, Fitzgibbons, DE, Scholes, D, Chen, C, Wahala, K, Schwartz, SM, Lampe, JW   +7 more
openaire   +3 more sources

Structure of lysine adducts with 16α-hydroxyestrone and cortisol

Journal of Steroid Biochemistry, 1986
Recent studies indicate that steroids containing a vicinal hydroxyketone moiety can react with proteins both in vitro and in vivo to form covalent addition products. This reaction is non-enzymatic and occurs via the Heyns rearrangement of an initial Schiff base adduct between the steroid carbonyl and the epsilon-amino group of lysine residues.
R, Bucala, P C, Ulrich, B T, Chait, F A, Bencsath, A, Cerami   +4 more
openaire   +2 more sources

Metabolic Clearance Rate and Uterotropic Activity of 2-Hydroxyestrone in Rats*

Endocrinology, 1981
2-Hydroxyestrone (2-OHE1) has much lower uterotropic potency than might be predicted from its uterine estrogen receptor affinity. 2-OHE1 displaces saturably bound [3H]estradiol from rat uterine cytosol with a competitive inhibition constant of 8.6 nM, while the dissociation constant for 17 beta-estradiol (E2) is 0.42 nM.
S, Kono, D D, Brandon, G R, Merriam, D L, Loriaux, M B, Lipsett   +4 more
openaire   +2 more sources

4-Hydroxyestrone: A new metabolite of estradiol-17β from humans

Steroids, 1974
Abstract 4-Hydroxyestrone has been identified, by reverse isotope dilution, as a urinary metabolite after injection of a mixture of 4- 3 H- and 4- 14 C-estradiol-17β into a 23 year old woman and a 39 year old man. This new metabolite accounted for 1.1% of the - 14 C dose administered to the woman and 0.51% of the - 14 C dose administered to the man ...
J G, Williams, C, Longcope, K I, Williams   +2 more
openaire   +2 more sources

Radioimmunoassay for 4-Hydroxyestrone 4-Methyl Ether in Human Urine

Hormone and Metabolic Research, 1982
4-Hydroxyestrone 4-methyl ether (4-OHE1 4-Me) was converted to its 17-(O-carboxymethyl)oxime and then coupled to bovine serum albumin. The injection of this steroid-protein conjugate into rabbits induced the formation of antibodies with high specificity and affinity for 4-OHE1 4-Me. With this antiserum a radioimmunoassay was developed which allowed the
G, Emons, B, Klinger, O, Haupt, P, Ball
openaire   +2 more sources

Conjugation of 2-Hydroxyestrone in Man

The Journal of Clinical Endocrinology & Metabolism, 1969
I, Yoshizawa, J, Fishman
openaire   +2 more sources

Species difference in the structure of urinary 2-hydroxyestrone “glucuronide”

Steroids, 1970
Abstract Metabolism of radioactive estrone by female rats and hamsters leads to excretion of urinary 2-hydroxyestrone conjugated with “glucuronic acid” exclusively at the 2 position. Simular experiments with the human are reported to give 2-hydroxyestrone conjugated at the 3 position (Yoshizawa and Fishman, J. Clin. Endocrin. Metab. 29 , 1123 (1969).
openaire   +2 more sources