Results 11 to 20 of about 132 (117)
Changes in 2-hydroxyestrone and 16alpha-hydroxyestrone metabolism with flaxseed consumption: modification by COMT and CYP1B1 genotype. [PDF]
Cancer Epidemiol Biomarkers Prev, 2007 Abstract Consumption of the phytoestrogen lignans, structurally similar to estrogen, has been associated with alterations in gene expression and estrogen metabolism. Furthermore, lignan consumption, subsequent changes in metabolizing enzyme expression, and genetic variability in these enzymes may alter estrogen metabolism and modify ...
McCann SE +10 more
europepmc +4 more sources
Effects of prune consumption on the ratio of 2-hydroxyestrone to 16α-hydroxyestrone [PDF]
The American Journal of Clinical Nutrition, 2002 A higher urinary ratio of the biologically inactive estrogen metabolite, 2-hydroxyestrone (2OHE1), to the biologically active metabolite, 16alpha-hydroxyestrone (16alphaOHE1), may be associated with a lower risk of breast cancer. High fiber intake is also associated with decreased breast cancer risk.We investigated the effects of prunes, which are ...
Sidika E, Kasim-Karakas +5 more
openaire +2 more sources
Urinary 2-Hydroxyestrone/16 -Hydroxyestrone Ratio and Risk of Breast Cancer in Postmenopausal Women [PDF]
JNCI Journal of the National Cancer Institute, 1999 It has been suggested that women who metabolize a larger proportion of their endogenous estrogen via the 16alpha-hydroxylation pathway may be at elevated risk of breast cancer compared with women who metabolize proportionally more estrogen via the 2-hydroxylation pathway. However, the supporting epidemiologic data are scant.
G, Ursin +6 more
openaire +2 more sources
Mass Spectrometry Reviews, Volume 42, Issue 4, Page 1424-1461, July/August 2023., 2023 Abstract Gestational diabetes (GDM) is one of the most common complications occurring during pregnancy. Diagnosis is performed by oral glucose tolerance test, but harmonized testing methods and thresholds are still lacking worldwide. Short‐term and long‐term effects include obesity, type 2 diabetes, and increased risk of cardiovascular disease.
Marco Roverso +6 more
wiley +1 more source
The Prostate, Volume 83, Issue 9, Page 823-830, June 15, 2023., 2023 Abstract Background Androgens are generally thought to cause prostate cancer, but the data from animal studies suggest that they must be aromatized to estrogen and act in concert with genotoxic estrogen metabolites. The objective of this study was to determine whether treatment with testosterone (T) combined with a nonestrogenic estrogen metabolite and
Maarten C. Bosland +3 more
wiley +1 more source
Pulmonary Circulation, Volume 13, Issue 2, April 2023., 2023 Abstract Pulmonary hypertension associated with bronchopulmonary dysplasia is a severe complication of preterm birth resulting in high mortality of up to 50% within the first 2 years of life. There is a direct relationship between bronchopulmonary dysplasia severity and incidence of associated pulmonary hypertension.
Roopa Siddaiah +8 more
wiley +1 more source
Urinary estrogen metabolites and gastric cancer risk among postmenopausal women
Cancer Reports, Volume 5, Issue 7, July 2022., 2022 Abstract Background The overall incidence of gastric cancer in women is half that in men for most global populations. Sex hormone pathways may be involved in carcinogenesis and estrogens have been postulated to protect women against gastric cancer. Aim To evaluate associations of gastric cancer with estrogen metabolites in postmenopausal women. Methods
M. Constanza Camargo +18 more
wiley +1 more source
Microbial Biotechnology, Volume 15, Issue 3, Page 949-966, March 2022., 2022 Actinobacteria were found to be key estrogen degraders in manure‐contaminated soils and estuarine sediments. In this study, we employed tiered comparative transcriptomics, gene disruption experiments, and mass spectrometry–based metabolite profile analysis to identify estrogen catabolic genes.
Tsun‐Hsien Hsiao +8 more
wiley +1 more source
Hypoxia: Role of SIRT1 and the protective effect of resveratrol in ovarian function
Reproductive Medicine and Biology, Volume 21, Issue 1, January/December 2022., 2022 Resveratrol may prevent mitochondrial dysfunction due to hypoxia or aging and that resveratrol treatment may be a potential therapy for treating infertility. Abstract Background Ovarian function is closely related to the degree of vascular network development surrounding the ovary.
Akemi Nishigaki +3 more
wiley +1 more source
SEPARATION SCIENCE PLUS, Volume 4, Issue 8, Page 286-295, August 2021., 2021 Abstract The detection of endocrine disrupting chemicals such as estrogenic compounds in environmental samples is a hot topic of research. In this context, this study describes a new screening method for 75 estrogenic chemicals from environmental water samples based on two databases built from the data obtained from liquid chromatography with ...
Mayuko Yagishita +4 more
wiley +1 more source