Results 51 to 60 of about 6,864 (172)

Regulatory Pathways of Monoamine Oxidase A during Social Stress

Frontiers in Neuroscience, 2017
Social stress has a high impact on many biological systems in the brain, including serotonergic (5-HT) system—a major drug target in the current treatment for depression. Hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis and monoamine oxidase A (
Yuki Higuchi, Tomoko Soga, Ishwar S. Parhar   +2 more
doaj   +1 more source

Validation of an ELISA assay for measurement of the metabolite of serotonin, 5‐hydroxyindole acetic acid (5‐HIAA), in canine urine

Journal of Small Animal Practice, Volume 67, Issue 8, Page 680-685, August 2026.
Objectives Serotonin (5‐hydroxytryptophan), implicated in a number of canine diseases, has a very short half‐life in the serum. Urine concentration of its breakdown product 5‐hydroxyindole acetic acid after an 8 hour fast is a more reliable measure of circulating serotonin in humans.
D. Castillo, A. Swallow, T. Williams, P. Watson   +3 more
wiley   +1 more source

Increase of Urinary 5-Hydroxyindoleacetic Acid Excretion but Not Serum Chromogranin a Following Over-The-Counter 5-Hydroxytryptophan Intake

Canadian Journal of Gastroenterology, 2008
BACKGROUND: 5-hydroxyindoleacetic acid (5-HIAA) excretion is commonly measured for biochemical detection of carcinoid tumours. A 77-year-old woman was referred for elevated 24 h urine 5-HIAA excretion (510 μmol/day; normal is less than 45 μmol/day) and ...
Tisha Joy, Grace Walsh, Sonya Tokmakejian, Stan HM Van Uum   +3 more
doaj   +1 more source

Cerebrospinal Fluid Concentrations of Biogenic Amines: Potential Biomarkers for Diagnosis of Bacterial and Viral Meningitis

Pathogens, 2018
Catecholamine and serotonin are biogenic amines (BAs) that serve as neurotransmitters and play an important role in the regulation of cardinal functions that are mainly altered during central nervous system (CNS) infections.
Aneela Taj, Nusrat Jamil
doaj   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, Volume 13, Issue 39, 13 July 2026.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Metabolic Fingerprints of High‐Risk Individuals for Pancreatic Cancer: A Multibiospecimen Investigation

Analysis &Sensing, Volume 6, Issue 4, July 2026.
This study presents a multimatrix untargeted metabolomics analysis of fecal, plasma, and urine samples from individuals at high risk for pancreatic cancer development. Integrated multivariate and cofactor‐adjusted models were applied to characterize cross‐matrix metabolomic associations, incorporating pancreatic magnetic resonance imaging data, sex ...
Vladyslav Dovhalyuk, Quang‐Dong Bui, Vincent Ripoll, Wiktor Rutkowski, Miroslav Vujasinovic, J.‐Matthias Löhr, Daniel Globisch   +6 more
wiley   +1 more source

The Effects of Transcranial Magnetic Stimulation on Tryptophan Metabolism and Depressive‐Like Behavior in Mice

Brain and Behavior, Volume 16, Issue 7, July 2026.
Repetitive transcranial magnetic stimulation (rTMS) ameliorates chronic unpredictable mild stress (CUMS)‐induced depressive‐like behaviors in mice by modulating key tryptophan metabolism pathways, as evidenced by the restoration of serotonin levels and reduction of neuroactive metabolites.
Gao Yuan, Wang Zihao, Leng Yujia, Luan Rongrong, Zhao Xin, Yang Juanini, Liu Junchang, Feng Yuchao, Wang Peng   +8 more
wiley   +1 more source

Urinary 5-HIAA as a Potential Diagnostic Marker in Acute Appendicitis: A Preliminary Report of Its Promising Role in Early Detection

Medicina
Background: Acute appendicitis (AA) is a common surgical emergency worldwide. Over the past few decades, diagnostic imaging has become a cornerstone in the identification of acute appendicitis, significantly contributing to the reduction in unnecessary ...
Murat Demir, Alper Gumus, Huseyin Kilavuz, Feyyaz Gungor, Sibel Yaman, Baki Ekci, Idris Kurtulus   +6 more
doaj   +1 more source

Aging Enhances Serotonergic Signaling via 5‐HT7 Receptors Underlying Mechanical Alloknesis

Aging Cell, Volume 25, Issue 7, July 2026.
Aging selectively enhances mechanical alloknesis. This is associated with altered systemic serotonin homeostasis and increased 5‐HT7 receptor expression in dorsal root ganglion neurons and spinal dorsal horn (laminae III–IV). Pharmacological inhibition of serotonergic signaling attenuates itch behavior.
Qiaofeng Zhao, Alberto Leguina‐Ruzzi, Mitsutoshi Tominaga, Yayoi Kamata, Atsuko Kamo, Huiying Wan, Bin Yin, Yuping Ran, Kenji Takamori   +8 more
wiley   +1 more source