The Metabolomics of Childhood Atopic Diseases: A Comprehensive Pathway-Specific Review
Asthma, allergic rhinitis, food allergy, and atopic dermatitis are common childhood diseases with several different underlying mechanisms, i.e., endotypes of disease.
Mette S. Schjødt +2 more
doaj +1 more source
Tyrosine hydroxylase deficiency: a treatable disorder of brain catecholamine biosynthesis [PDF]
Tyrosine hydroxylase deficiency is an autosomal recessive disorder resulting from cerebral catecholamine deficiency. Tyrosine hydroxylase deficiency has been reported in fewer than 40 patients worldwide. To recapitulate all available evidence on clinical
Aeby, Alec +31 more
core
During the past decade, there has been a substantial rise in the knowledge about the effects of gut microbiota on host physiology and behavior, including depressive behavior.
Iva Lukić +3 more
doaj +1 more source
Telotristat ethyl in carcinoid syndrome: safety and efficacy in the TELECAST phase 3 trial [PDF]
Telotristat ethyl, a tryptophan hydroxylase inhibitor, was efficacious and well tolerated in the phase 3 TELESTAR study in patients with carcinoid syndrome (CS) experiencing ≥4 bowel movements per day (BMs/day) while on somatostatin analogs (SSAs ...
Anthony, Lowell B. +17 more
core +2 more sources
This meta‐analysis of seven RCTs (n = 489) demonstrates that acupuncture significantly improves depression scores, hirsutism, and BMI in PCOS patients, though anxiety symptoms show no significant improvement. Evidence quality is low, warranting cautious interpretation. ABSTRACT Introduction Preliminary studies have indicated that acupuncture may play a
Lanfeng Lai +7 more
wiley +1 more source
Regulatory Pathways of Monoamine Oxidase A during Social Stress
Social stress has a high impact on many biological systems in the brain, including serotonergic (5-HT) system—a major drug target in the current treatment for depression. Hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis and monoamine oxidase A (
Yuki Higuchi +2 more
doaj +1 more source
Synchronous primary papillary breast cancer, medullary thyroid carcinoma and neuroendocrine tumor in postmenopausal woman. [PDF]
Multiple endocrine neoplasia are syndromes involving two or more endocrine tissues, often correlated to RET proto-oncogene mutations. We herein present the first reported case of a 57-years-old woman with three synchronous primary cancers of breast ...
DE IULIIS, Francesca +7 more
core
Prediction of progression-free survival in patients with advanced, well-differentiated, neuroendocrine tumors being treated with a somatostatin analog: the GETNE-TRASGU study [PDF]
Artículo escrito por un elevado número de autores, sólo se referencian el que aparece en primer lugar, y los autores pertenecientes a la UAMSomatostatin analogs (SSAs) are recommended for the first-line treatment of most patients with well ...
Carmona Bayonas, Alberto +1 more
core +1 more source
Role of Tryptophan Metabolism in Cancer
This review systematically summarizes the functions and related mechanisms of tryptophan metabolism in various tumor types. It presents the latest progress in this field in a comprehensive manner and combines this with clinical practice to offer a new perspective on tumor treatment.
Zhehao Cui +5 more
wiley +1 more source
Neurotoxicity induced by mephedrone: an up-to-date review [PDF]
BACKGROUND: Mephedrone is a β-ketoamphetamine belonging to the family of synthetic cathinones, an emerging class of designer drugs known for their hallucinogenic and psychostimulant properties as well as for their abuse potential.
Busardo', FRANCESCO PAOLO +6 more
core +1 more source

