Recent Advances in N-O Bond Cleavage of Oximes and Hydroxylamines to Construct N-Heterocycle
Molecules, 2023 Oximes and hydroxylamines are a very important class of skeletons that not only widely exist in natural products and drug molecules, but also a class of synthon, which have been widely used in industrial production.
Xuan-Hui Ouyang, Jin-Heng Li
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Recent Advances in the Synthesis of Di- and Trisubstituted Hydroxylamines
Molecules, 2023 As an underrepresented functional group in bioorganic and medicinal chemistry, the hydroxylamine unit has historically received little attention from the synthetic community.
Jarvis Hill, Thomas Beckler, David Crich
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Ceria–Zirconia-Supported Pt as an Efficient Catalyst for the Sustainable Synthesis of Hydroxylamines and Primary Amines via the Hydrogenation of Oximes Under Ambient Conditions [PDF]
MoleculesAmines and hydroxylamines are essential compounds in the synthesis of pharmaceuticals and other functionalized molecules. However, the synthesis of primary amines and particularly hydroxylamines remains a challenging task.
Elena Redina +5 more
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Crown-hydroxylamines are pH-dependent chelating N,O-ligands with a potential for aerobic oxidation catalysis [PDF]
Nature Communications, 2023 Despite the rich coordination chemistry, hydroxylamines are rarely used as ligands for transition metal coordination compounds. This is partially because of the instability of these complexes that undergo decomposition, disproportionation and oxidation ...
Vladislav K. Lesnikov +4 more
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Competition of the Addition/Cycloaddition Schemes in the Reaction Between Fluorinated Nitrones and Arylacetylenes: Comprehensive Experimental and DFT Study [PDF]
MoleculesThe course of the reactions of acetylenes with fluorinated nitrones in the presence of Zn(OTf)2 and Et2Zn was investigated. The formation of hydroxylamines and/or 1,2-oxazolines as products was observed.
Szymon Jarzyński +4 more
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Expedient Organocatalytic Syntheses of 4-Substituted Pyrazolidines and Isoxazolidines [PDF]
Molecules, 2016 The efficient organocatalytic synthesis of heterocyclic systems of biological relevance is a subject of growing interest. We have found that the pyrrolidine/benzoic acid-catalyzed reaction of α-substituted propenals such as methacrolein, 2-benzylpropenal
Tarek Yousfi +4 more
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Trifluoroethanol-assisted asymmetric propargylic hydrazination to α-tertiary ethynylhydrazines enabled by sterically confined pyridinebisoxazolines [PDF]
Nature CommunicationsWe report the highly enantioselective Cu-catalyzed asymmetric propargylic substitution (APS) of α-tertiary propargylic electrophiles using hydrazines and hydroxylamines as a fruitful strategy to access multifunctional α-tertiary hydrazines or ...
Yi Gong +10 more
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Application of a fully 3D printed carbon electrode for the double potential step Chronoamperometric determination of 2,4-dinitrophenol in environmental water samples [PDF]
Frontiers in ChemistryIntroductionThe detection of nitrophenolic compounds in environmental water sources is critical due to their toxicity and persistence. This study presents the first reported application of a fully 3D printed carbon nanofiber-graphite-polystyrene working ...
Daniel Steven Shaw +4 more
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Examining the effects of additives and precursors on the reactivity of rhodium alkyl nitrenes generated from substituted hydroxylamines [PDF]
Frontiers in Chemistry, 2023 In this study, the reactivity of the alkyl nitrenes, generated from the substituted hydroxylamine precursors, was determined using the same rhodium catalyst. The results revealed that in competitive C–H insertion experiments, the regioselectivity between
Hidetoshi Noda +2 more
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Noninvasive in vivo discrimination between mitochondrial ROS and global ROS production in solid tumors using EPR spectroscopy [PDF]
Redox BiologyBecause the precise site of ROS production plays a key role in cellular redox signaling and its (patho)physiological consequences, it is crucial to develop tools that enable site-specific detection of ROS in complex systems, including in vivo.
Barbara Mathieu +4 more
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