Results 11 to 20 of about 8,900 (267)
Peptide-Directed Attachment of Hydroxylamines to Specific Lysines of IgG Antibodies for Bioconjugations with Acylboronates [PDF]
, 2023 The role of monoclonal antibodies as vehicles to deliver payloads has evolved as a powerful tool in cancer therapy in recent years. The clinical development of therapeutic antibody-conjugates with precise payloads holds great promise for targeted ...
Sohei, Majima +5 more
core +2 more sources
2-aminophenols containing electron-withdrawing groups from N-aryl hydroxylamines [PDF]
, 2010 Reaction of substituted N-aryl hydroxylamines with methanesulfonyl chloride, p-toluenesulfonyl chloride, or trifluoromethanesulfonic anhydride under basic conditions leads to the rearranged 2-aminophenols (45-94%).
Cooper, Anthony W. J. +7 more
core +4 more sources
Urea Synthesis from Isocyanides and O-Benzoyl Hydroxylamines Catalyzed by a Copper Salt
Molecules, 2022 In the presence of CuOAc, a series of unsymmetric ureas can be generated in moderate to good yields under mild reaction conditions (10 mol% of CuOAc, 2 equiv t-BuONa or PhONa, 30 °C), using aryl isocyanides and O-benzoyl hydroxylamines as the readily ...
Ning Yu +5 more
doaj +1 more source
Molecules, 2022 Herein the reaction mechanism and the origin of stereoselectivity of asymmetric hydrogenation of oximes to hydroxylamines catalyzed by the cyclometalated iridium (III) complexes with chiral substituted single cyclopentadienyl ligands (Ir catalysts A1 and
Qaim Ali +6 more
doaj +1 more source
Copper-catalyzed coupling of hydroxylamines with aryl iodides.
, 2008 An efficient method for the copper-catalyzed N-arylation of hydroxylamines with aryl iodides is described. A variety of N- and O-functionalized hydroxylamines, e.g., I, were transformed in good to excellent yield with a broad range of aryl coupling ...
Hall, Adrian +4 more
core +4 more sources
Kinetic resolution of indolines by asymmetric hydroxylamine formation
Nature Communications, 2021 Catalytic kinetic resolution of amines is a longstanding challenge in chemical synthesis. Here, the authors report on titanium‐catalysed asymmetric oxygenation with hydrogen peroxide for kinetic resolution of secondary amines through oxygenation to ...
Gang Wang +3 more
doaj +1 more source
O-((Ferrocenyl)(3-fluorophenyl)methyl)hydroxylamine
Molbank, 2022 Based on the diaryl hydroxylamine scaffold, which exhibits the potential to inhibit all three enzymes of the first step of the kynurenine pathway, the main tryptophan degradation pathway in mammals, which is often activated in cancer, we report herein ...
Angeliki S. Foscolos +3 more
doaj +1 more source
Dynamic Amide Formation by Reversible Nitrone Exchange of Potassium Acyltrifluoroborates (KATs) and Hydroxylamines in Aqueous Conditions [PDF]
, 2021 The condensation of potassium acyltrifluoroborates (KATs) and hydroxylamines occurs under ambient, aqueous conditions to form KAT nitrones in a reversible manner.
Yi-Chung, Dzeng, Jeffrey, Bode
core +2 more sources
Molecules, 2016 Alkyl aryl sulfones were prepared in high yields via the reaction of N-arylsulfonyl hydroxylamines with electron-deficient alkenes. These reactions have the advantages of simplicity, easily available starting materials and mild reaction conditions.
Yunhui Bin, Ruimao Hua
doaj +1 more source
Expedient Organocatalytic Syntheses of 4-Substituted Pyrazolidines and Isoxazolidines
Molecules, 2016 The efficient organocatalytic synthesis of heterocyclic systems of biological relevance is a subject of growing interest. We have found that the pyrrolidine/benzoic acid-catalyzed reaction of α-substituted propenals such as methacrolein, 2-benzylpropenal
Tarek Yousfi +4 more
doaj +1 more source