Oxidation of N,N-Disubstituted Hydroxylamines to Nitrones: The Search for More Sustainable Selective and Practical Stoichiometric Oxidants [PDF]
CHIMIA, 2017 Nitrones are key intermediates for the total synthesis of nitrogen-containing natural products and analogues. The direct oxidation of the corresponding N,N-disubstituted hydroxylamines is one of the most straightforward methods to access such ...
Camilla Matassini, Francesca Cardona
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Noninvasive in vivo discrimination between mitochondrial ROS and global ROS production in solid tumors using EPR spectroscopy [PDF]
Redox BiologyBecause the precise site of ROS production plays a key role in cellular redox signaling and its (patho)physiological consequences, it is crucial to develop tools that enable site-specific detection of ROS in complex systems, including in vivo.
Barbara Mathieu +4 more
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Polar-to-Radical Crossover in Catalyst-Free Olefin Halo-Hydroxylamination: A Direct Route to Multifunctional Electrophilic Hydroxylamines [PDF]
JACS AuYoung-Do Kwon +7 more
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Peptide-Directed Attachment of Hydroxylamines to Specific Lysines of IgG Antibodies for Bioconjugations with Acylboronates [PDF]
, 2023 The role of monoclonal antibodies as vehicles to deliver payloads has evolved as a powerful tool in cancer therapy in recent years. The clinical development of therapeutic antibody-conjugates with precise payloads holds great promise for targeted ...
Sohei, Majima +5 more
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Urea Synthesis from Isocyanides and O-Benzoyl Hydroxylamines Catalyzed by a Copper Salt
Molecules, 2022 In the presence of CuOAc, a series of unsymmetric ureas can be generated in moderate to good yields under mild reaction conditions (10 mol% of CuOAc, 2 equiv t-BuONa or PhONa, 30 °C), using aryl isocyanides and O-benzoyl hydroxylamines as the readily ...
Ning Yu +5 more
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Molecules, 2022 Herein the reaction mechanism and the origin of stereoselectivity of asymmetric hydrogenation of oximes to hydroxylamines catalyzed by the cyclometalated iridium (III) complexes with chiral substituted single cyclopentadienyl ligands (Ir catalysts A1 and
Qaim Ali +6 more
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Dynamic Amide Formation by Reversible Nitrone Exchange of Potassium Acyltrifluoroborates (KATs) and Hydroxylamines in Aqueous Conditions [PDF]
, 2021 The condensation of potassium acyltrifluoroborates (KATs) and hydroxylamines occurs under ambient, aqueous conditions to form KAT nitrones in a reversible manner.
Yi-Chung, Dzeng, Jeffrey, Bode
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2,2,2-Trifluoroethyl Formate: A Versatile and Selective Reagent for the Formylation of Alcohols, Amines, and N-Hydroxylamines [PDF]
, 2016 Treatment of a variety of alcohols, amines, and N-hydroxylamines with 2,2,2-trifluoroethyl formate gave the corresponding formylated adducts in high ...
Chi-Nung Hsiao (1651861) +3 more
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Kinetic resolution of indolines by asymmetric hydroxylamine formation
Nature Communications, 2021 Catalytic kinetic resolution of amines is a longstanding challenge in chemical synthesis. Here, the authors report on titanium‐catalysed asymmetric oxygenation with hydrogen peroxide for kinetic resolution of secondary amines through oxygenation to ...
Gang Wang +3 more
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O-((Ferrocenyl)(3-fluorophenyl)methyl)hydroxylamine
Molbank, 2022 Based on the diaryl hydroxylamine scaffold, which exhibits the potential to inhibit all three enzymes of the first step of the kynurenine pathway, the main tryptophan degradation pathway in mammals, which is often activated in cancer, we report herein ...
Angeliki S. Foscolos +3 more
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