Results 71 to 80 of about 10,848 (250)

Thermally Gated Dual‐Cascade Nanozyme for Enhanced Mild‐Temperature Photothermal Therapy

Advanced Science, EarlyView.
A thermo‐responsive cascade nanozyme (Ru‐GOx‐PNN) synergistically enhances mild photothermal therapy by dual suppression of HSP70 through ROS‐induced lipid peroxidation and ATP depletion. This intelligent system effectively overcomes thermotolerance and amplifies apoptosis, offering a safe and precise strategy for tumor treatment.
Shuyu Wang, Shenghui Wang, Mengyuan Cao, Lulu Wang, Wei Jiang, Xiyun Yan, Ying Liu, Bing Jiang   +7 more
wiley   +1 more source

Preparation of substituted tetrahydroisoquinolines by Pd(II)-catalyzed NH2-directed insertion of Michael acceptors into C-H bonds followed by NH2-conjugated additions [PDF]

, 2017
3,3-Disubstituted tetrahydroisoquinolines are prepared in one step from Michael acceptors and 2-phenylethylamines under Pd catalysis and Ag2CO3 as an oxidant. Presumably, activation of an ortho C-H bond of the aromatic ring with Pd(II) is directed by the
Alamillo, Carla, Albert Mach, Joan, Ariza Piquer, Xavier, Etxabe, Haizea, Farràs i Soler, Jaume, García Gómez, Jordi, Granell Sanvicente, Jaime Ramón, Mancinelli, Andrea, Quijada, F. Javier   +8 more
core   +1 more source

Bifunctional Artificial Enzymes‐Loaded Microgels With LOX‐ and CAT‐Like Activities for Metabolic Reprogramming and Scarless Wound Repair

Advanced Science, EarlyView.
A bifunctional lactate oxidase‐like and catalase‐like artificial enzyme (Metazyme) is integrated into a rod‐shaped microgel (MetaRgel) to enable cascade lactate oxidation and oxygen regeneration. By reprogramming the wound metabolic microenvironment, MetaRgel alleviates excessive lactate accumulation, oxidative stress, hypoxia, and inflammation ...
Yongyuan Kang, Pai Peng, Liang Song, Qiaoxuan Wang, Zilong Zhong, Dongchao Qiu, Yunfan Liu, Kefei Zhao, Xiaofei Dong, Changyou Gao   +9 more
wiley   +1 more source

A Biomimetic Total Synthesis of Clivonine

, 2011
The first chapter of this thesis discusses the biomimetic total synthesis of clivonine. Clivonine is a member of the Amaryllidaceae family of alkaloids and was isolated from the plant Clivia miniata Regel by Wildman in 1956.
Paddock, Victoria L., Paddock, Victoria L.   +1 more
core   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Mechanism of Two-/Four-Electron Reduction of Nitroaromatics by Oxygen-Insensitive Nitroreductases: The Role of a Non-Enzymatic Reduction Step

Molecules, 2018
Oxygen-insensitive NAD(P)H:nitroreductases (NR) reduce nitroaromatics (Ar-NO2) into hydroxylamines (Ar-NHOH) through nitroso (Ar-NO) intermediates. Ar-NO may be reduced both enzymatically and directly by reduced nicotinamide adenine dinucleotide or its ...
Benjaminas Valiauga, Lina Misevičienė, Michelle H. Rich, David F. Ackerley, Jonas Šarlauskas, Narimantas Čėnas   +5 more
doaj   +1 more source

Ethylamine-driven amination of organic particles: mechanistic insights via key intermediates identification [PDF]

Atmospheric Chemistry and Physics
Atmospheric amines critically contribute to secondary aerosols formation via heterogeneous reactions, yet the molecular mechanisms governing heterogeneous amination chemistry of aerosols remain unclear.
P. Liu, J. Gao, Y. Hu, W. Yuan, Z. Zhou, F. Qi, M. Zeng   +6 more
doaj   +1 more source

Comparison of boron-assisted oxime and hydrazone formations leads to the discovery of a fluorogenic variant [PDF]

, 2016
We use kinetic data, photophysical properties, and mechanistic analyses to compare recently developed high-rate constant oxime and hydrazone formations.
Gillingham, Dennis, Schmidt, Pascal, Stress, Cedric   +2 more
core   +1 more source

Molecular Probes for Evaluation of Oxidative Stress by In Vivo EPR Spectroscopy and Imaging: State-of-the-Art and Limitations

Magnetochemistry, 2019
Oxidative stress, defined as a misbalance between the production of reactive oxygen species and the antioxidant defenses of the cell, appears as a critical factor either in the onset or in the etiology of many pathological conditions.
Nikola Babić, Fabienne Peyrot
doaj   +1 more source

Redox nanoparticle therapeutics to cancer — increase in therapeutic effect of doxorubicin, suppressing its adverse effect [PDF]

, 2013
The ultimate goal of cancer chemotherapy is to achieve a cure without causing any adverse effects. We have developed a pH-sensitive redox nanoparticle (RNPN), which disintegrates under acidic conditions and exposes nitroxide radicals, leading to strongly
Nagasaki Yukio, Ozaki Yuki, Thangavel Sindhu, Yoshitomi Toru, 吉冨 徹, 長崎 幸夫   +5 more
core   +1 more source