Results 321 to 330 of about 194,006 (386)

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Comprehensive <i>in vivo</i> and <i>in vitro</i> metabolic profiling of amphenmulin: a novel pleuromutilin derivative characterized by UHPLC-Q-TOF-MS/MS. [PDF]

Front Vet Sci
Wang W, Wang L, Deng Q, Su D, Tang Y, Ding H.   +5 more
europepmc   +1 more source

The curious family of cytochrome P450 4F fatty acid ω-hydroxylases: recent developments in their function and relevance for human health. [PDF]

Open Biol
Alves Chagas BC, Jia H, Brixius B, Brixius-Anderko S.   +3 more
europepmc   +1 more source

Inhibitory effects of Δ8-tetrahydrocannabinol on major hepatic cytochrome P450 enzymes and implications for drug disposition. [PDF]

Drug Metab Dispos
Zhao M, Coates S, Bardhi K, Lazarus P.
europepmc   +1 more source

Lactylation modification of HIF-1α enhances its stability by blocking VHL recognition. [PDF]

Cell Commun Signal
Li C, Fu C, Zhou W, Li H, Liu Z, Wu G, He T, Shen M, Liu H.   +8 more
europepmc   +1 more source

Ultrasound-triggered prodrug activation <i>via</i> sonochemically induced cleavage of a 3,5-dihydroxybenzyl carbamate scaffold. [PDF]

Chem Sci
Fu X, Xu B, Liyanage H, Zhang C, Kincaid WF, Ford AL, Westbrook LG, Brown SD, DeMarco T, Hougland JL, Franck JM, Hu X.   +11 more
europepmc   +1 more source

The neuroendocrine regulation of hepatic cytochrome P450 by N-methyl-D-aspartate receptors in the paraventricular and arcuate nuclei of the hypothalamus. [PDF]

Drug Metab Dispos
Pukło R, Bromek E, Basińska-Ziobroń A, Haduch A, Kuban W, Danek PJ, Daniel WA.   +6 more
europepmc   +1 more source

Electrochemical hydroxylation of alkenes with H2O

Guoqing Yang, Jingpei Jia, Yuan Deng, Youai Qiu   +3 more
openalex   +1 more source

Engineering Membrane-Bound Alkane Monooxygenase from Marinobacter sp. for Increased Activity in the Selective ω-Hydroxylation of Linear and Branched Aliphatic Esters

Spasic J, Nigl A, Cheon H, Kaiserer CL, Galušić S, van der Pol E, Malihan-Yap L, Park J, Kourist R.   +8 more
europepmc   +1 more source