Results 101 to 110 of about 350,851 (339)
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Hachimoji DNA and RNA: A genetic system with eight building blocks [PDF]
, 2019 Reported here are DNA and RNA-like systems built from eight (hachi-) nucleotide letters (-moji) that form four orthogonal pairs. This synthetic genetic biopolymer meets the structural requirements needed to support Darwinism, including a polyelectrolyte ...
Bates, Alison M. +15 more
core +1 more source
Thermally Gated Dual‐Cascade Nanozyme for Enhanced Mild‐Temperature Photothermal Therapy
Advanced Science, EarlyView.A thermo‐responsive cascade nanozyme (Ru‐GOx‐PNN) synergistically enhances mild photothermal therapy by dual suppression of HSP70 through ROS‐induced lipid peroxidation and ATP depletion. This intelligent system effectively overcomes thermotolerance and amplifies apoptosis, offering a safe and precise strategy for tumor treatment.
Shuyu Wang +7 more
wiley +1 more source
Acta Pharmaceutica Sinica B, 2012 Eight new 9,10-anthraquinones (1–8) including three acetonide derivatives of 3-hydroxy-2-hydroxymethyl-9,10-anthraquinones (6–8) were isolated from an ethanol extract of the roots of Knoxia valerianoides. On the basis of chemical transformation reactions
Feng Zhao +10 more
doaj +1 more source
The Role of Organic Peroxides in the Induction of Mutations [PDF]
, 1949 The discovery by Wyss, Stone, and Clark' that bacteria grown on a substrate recently exposed to ultra-violet light are subject to high mutation rates shows clearly that some meta-stable chemical substance, probably of no great complexity, is an ...
Cleland, George H. +2 more
core +1 more source
Measures of hydroxymethylation
, 2017 Hydroxymethylcytosine (5hmC) methylation is known to be a possible epigenetic mark impacting genome stability. In this paper, we address the existing 5hmC measure $ $ and discuss its properties both analytically and empirically on real data. Then we introduce several alternative hydroxymethylation measures and compare their properties with those of $
Slynko, Alla, Benner, Axel
openaire +2 more sources
Development of Dimethylsulfonium Probes for Broad Profiling of Methyllysine Reader Proteins
Advanced Science, EarlyView.Development of oligoglycine‐based dimethylsulfonium probes for unbiased crosslinking to methyllysine readers. The general probe facilitates profiling of site‐specific methyllysine readers, evaluation of selectivity and activity of reader inhibitors, and global profiling of methyllysine readers.
Jinyu Yang +3 more
wiley +1 more source
Crystal structure of potassium (1R)-d-ribit-1-ylsulfonate
Acta Crystallographica Section E, 2014 The title compound, K+·C5H11O8S− [systematic name: potassium (1R,2R,3R,4R)-1,2,3,4,5-pentahydroxypentane-1-sulfonate], formed by reaction of d-ribose with potassium hydrogen sulfite in water, crystallizes as colourless plates. The anion has an open-chain
Alan H. Haines, David L. Hughes
doaj +1 more source
Advanced Science, EarlyView.Under the weakly alkaline condition, at pH 12, the *OH adsorption–mediated mechanism of direct aldehyde oxidation is demonstrated to complete HMF oxidation to FDCA, obtaining >95% selectivity and yield. In OH−‐deficient media, high FDCA selectivity is achieved on the CuO/NiOOH interface, a synergistic active site, where Cu enhances *OH utilization, and
Eunchong Lee +8 more
wiley +1 more source