Results 111 to 120 of about 189,846 (385)

Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

Advanced Science, EarlyView.
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu, Zhengyuan Zhou, Sascha Schäuble, Wolfgang Vivas, Karen Dlubatz, Michael Bauer, Sebastian Weis, Mervyn Singer, Roman Lukaszewski, Gianni Panagiotou   +9 more
wiley   +1 more source

Electrochemical Deoxygenative Silylation of Alcohols

Angewandte Chemie, EarlyView.
Herein, electroreductive deoxysilylation of benzylic and allylic alcohols is demonstrated. The cathodic transformation proceeds via carbanionic intermediates and can be extended to aldehydes and ketones. Mechanistic studies reveal that the reaction outcome is dependent on the thermodynamics and kinetics for the coupling step in combination with the ...
Piret Villo, Malin Lill, Ziwei Fan, Kevin Breitwieser, Jai White, Sergio Pérez Morente, Mårten Ahlquist, Helena Lundberg   +7 more
wiley   +2 more sources

REACTIVITY OF CHLOROPHYLL a/b-PROTEINS AND MICELLAR TRITON X-100 COMPLEXES OF CHLOROPHYLLS a OR b WITH BOROHYDRIDE [PDF]

, 1989
The reaction of several plant chlorophyll-protein complexes with NaBH4 has been studied by absorption spectroscopy. In all the complexes studied, chlorophyll b is more reactive than Chi a, due to preferential reaction of its formyl substituent at C-7 ...
Arnon D. I., Beese D., Brody S. S., Brune D. C., Ford R. C., Holt A. S., Holten D., Michel H., Olson J. M., Omata T., Ryrie I. J., Scheer H., Scheer H., Schoch S., Siefermann-Harms D., Smith K. M.   +15 more
core   +1 more source

β‐Mangostin Attenuates TET2‐Mediated DNA Demethylation of Prkcg in the Prevention of Intervertebral Disc Degeneration

Advanced Science, EarlyView.
β‐Mangostin alleviates intervertebral disc degeneration through dual modulation of macrophage polarization and the TET2‐Prkcg axis in nucleus pulposus cells. Abstract Intervertebral disc degeneration (IDD) induced lower back pain is a main cause of disability, resulting in a substantial workforce loss worldwide and placing a substantial burden on the ...
Xiangzhen Kong, Hanwen Gu, Yuanqiang Zhang, Qunbo Meng, Qi Li, Kangle Song, Yanlin Li, Kaiwen Liu, Zhenchuan Liu, Rui Hu, Haoxi Zhai, Tian Li, Zemin Ling, Zhijian Wei, Fuxin Wei, Lei Cheng   +15 more
wiley   +1 more source

Rapid Synthesis and Diversification of Thymine‐Containing Bridged Nucleic Acids Through Cascade Cyclization Reactions

Angewandte Chemie, EarlyView.
Several processes are reported that enable the rapid diversification of bridged nucleoside analogues (NAs) starting from a common and readily prepared fluorohydrin. Also, several clinically relevant bridged nucleosides are now prepared in as few as three synthetic steps, creating new opportunities for examining structure‐activity relationships within ...
Cohan Huxley, Ethan Fung, Bara Singh, Guillermo Caballero‐García, Garrett Muir, Steven M. Silverman, Louis‐Charles Campeau, Robert Britton   +7 more
wiley   +2 more sources

(S)-2,2′-Dihydroxy-N,N′-(6-hydroxyhexane-1,5-diyl)dibenzamide

Acta Crystallographica Section E, 2013
In the title compound, C20H24N2O5, the dihedral angle between the two roughly planar salicylamide fragments [r.m.s. deviations = 0.043 (2) and 0.149 (2) Å] is 25.50 (5)°.
Sabine Wilbrand, Christian Neis, Kaspar Hegetschweiler   +2 more
doaj   +1 more source

Experimental and theoretical investigation of ligand effects on the synthesis of ZnO nanoparticles [PDF]

, 2012
ZnO nanoparticles with highly controllable particle sizes(less than 10 nm) were synthesized using organic capping ligands in Zn(Ac)2 ethanolic solution.
A Dev, A Dijken van, A Forleo, A Neubauer, A Wood, AD Becke, AJ Morfa, B Luo, B Meyer, BJ Norris, C Deng, C Pacholski, D Jian, DW Bahnemann, E Wahlström, EA Meulenkamp, EM Wong, Eric R. Waclawik, FA Kroger, G Ballerini, H Usui, H Xu, J Dvorak, J Mao, J Wang, JBL Martins, Jin Chang, JJ Wu, JM Vohs, JM Vohs, JR Heath, K Park, K Westermark, KJ Choi, KJ Klabunde, L Liao, L Qian, L Spanhel, L Spanhel, LL Xu, M Anpo, M Kahn, M Shim, M Yin, MP Shortell, NS Norberg, NS Pesika, NU Zhanpeisov, PD Cozzoli, PJ Hay, PJ Hay, PLA Popelier, PW Sadik, R Bader, R Wahab, RG Parr, S Irrera, S Sakohara, S Sakohara, SF Boys, U Koch, WR Wadt, WU Huynh, X Lü, X Xing, XH Liu, Y Jouane, Y Li, Y Paukku   +68 more
core   +3 more sources

Rapid intraoperative visualization of breast lesions with γ-glutamyl hydroxymethyl rhodamine green

Scientific Reports, 2015
We previously developed γ-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG) as a tool to detect viable cancer cells, based on the fact that the enzyme γ-glutamyltranspeptidase (GGT) is overexpressed on membranes of various cancer cells, but is not ...
H. Ueo, Y. Shinden, Taro Tobo, A. Gamachi, Mitsuaki Udo, H. Komatsu, Sho Nambara, Tomoko Saito, M. Ueda, H. Hirata, S. Sakimura, Yuki Takano, R. Uchi, J. Kurashige, S. Akiyoshi, T. Iguchi, H. Eguchi, K. Sugimachi, Y. Kubota, Y. Kai, K. Shibuta, Y. Kijima, H. Yoshinaka, S. Natsugoe, M. Mori, Y. Maehara, M. Sakabe, M. Kamiya, J. Kakareka, T. Pohida, P. Choyke, Hisataka Kobayashi, H. Ueo, Y. Urano, K. Mimori   +34 more
semanticscholar   +1 more source

Molten‐Salt‐Mediated Synthesis of Atomic Manganese/Cobalt Catalysts on Bioceramic Microparticles for Catalytic Anti‐Osteoarthritis Treatments

Advanced Science, EarlyView.
Microparticle‐based antioxidants capable of scavenging multiple reactive oxygen species (ROS) have been developed. When retained within the articular cavity of osteoarthritic mice, Mn‐ or Co‐AKT‐MPs protect the inherent homeostasis between cartilage anabolism and catabolism, and inhibit synovial inflammation.
Ronghui Deng, Zining Zhang, Aijun Wu, Chaoqin Shu, Shitang Song, Fuzhen Yuan, Zijie Xu, Meng Yang, Jing Ye, Yifan Song, Yufang Zhu, Jia‐Kuo Yu   +11 more
wiley   +1 more source

Polymorphic α‐Glucans as Structural Scaffolds in Cryptococcus Cell Walls for Chitin, Capsule, and Melanin: Insights From 13C and 1H Solid‐State NMR

Angewandte Chemie, EarlyView.
Cryptococcus neoformans cell wall α‐1,3‐glucans as dual anchors for melanin and capsule: Solid‐state NMR of intact C. neoformans cells reveals five forms of α‐1,3‐glucans that structurally bridge melanin and capsule layers. These polysaccharides interact with chitin, chitosan, and β‐glucans to create a molecular scaffold that underlies virulence and ...
Ankur Ankur, Jayasubba Reddy Yarava, Isha Gautam, Faith J. Scott, Frederic Mentink‐Vigier, Christine Chrissian, Li Xie, Dibakar Roy, Ruth E. Stark, Tamara L. Doering, Ping Wang, Tuo Wang   +11 more
wiley   +2 more sources