Results 171 to 180 of about 142,060 (347)

Total synthesis of hydroxymethyl isonucleosides as potential antiviral agents

open access: yesARKIVOC, 2003
Vasu Nair, Byoung-Kwon Chun
doaj   +1 more source

Glycans and Chirality: Stereoselectivity at the Core of DC‐SIGN's Recognition. A Novel View of the Optimum Minimal Ligand Epitope

open access: yesChemistry – A European Journal, EarlyView.
The stereochemical diversity of the “glycan code” enables similar chiral motifs to arise from both D‐ and L‐sugars. Focused on DC‐SIGN–glycan recognition, two diverse monosaccharide scaffolds, D‐Man (D‐Rha) and L‐Gal (L‐Fuc), maintain the exquisite stereochemistry encoded in the minimal binding epitope.
J. Daniel Martínez   +7 more
wiley   +1 more source

Oxidative Dehydrogenation of N‐Heteroaromatic Alkyl Alcohols and Amines Facilitated by Dearomative Tautomerization

open access: yesChemistry – A European Journal, EarlyView.
N‐heteroaromatic alkyl alcohols and amines are inherently unstable in acidic and/or basic solution due to an irreversible dehydrogenation that proceeds from a minority tautomer. In many cases, this reaction results in quantitative oxidation to the corresponding aldehyde, providing a simple, convenient, and green approach for preparing versatile ...
Omid Ghasemloo   +4 more
wiley   +1 more source

Recent Advances in Detergent Chemistry and Handling Support Membrane Protein Analysis Including Lipid Interactions

open access: yesChemistry – A European Journal, EarlyView.
Detergent design parameters determine experimental successes in membrane protein research. Recent progresses in detergent chemistry are reviewed to promote the top‐down design of non‐ionic detergents for the purification and analysis of intact membrane proteins, including lipid interactions.
Katharina Alker   +2 more
wiley   +1 more source

Synthesis and biological characterization of 4,4‐difluoro‐3(phenoxymethyl)piperidine scaffold as dopamine 4 receptor (D4R) antagonist in vitro tool compounds

open access: yesChemMedChem, Accepted Article.
We report the discovery and characterization of a novel series of 4,4‐difluoropiperidine etherbased dopamine D4 receptor antagonists. Structure‐activity relationship studies led to the identification of compound 14a, which displays exceptional binding affinity for the D4 receptor (Ki = 0.3 nM) and remarkable selectivity over other dopamine receptor ...
Saeedeh Saeedi   +3 more
wiley   +1 more source

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