Results 181 to 190 of about 385,761 (370)

Feedback control of excitability and high K+ induced epileptiform bursts in male rat hippocampal slices with a photocaged adenosine A1 receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Adenosine is a potent regulator of neurotransmission and neuronal excitability, through activation of Gi coupled adenosine A1 receptors (A1Rs). Adenosine has gained interest as an anticonvulsant because of its endogenous involvement in ending seizure activity, but peripheral side effects require local application.
Erine Craey, Marijke Vergaelen, Serge Van Calenbergh, Jeroen Spanoghe, Evelien Carrette, Kristl Vonck, Paul Boon, Wytse J. Wadman, Robrecht Raedt   +8 more
wiley   +1 more source

Marked Impact of Regulatory Bans on Formaldehyde and Formaldehyde‐Releaser‐Induced Allergic Contact Dermatitis: A Retrospective Cohort Study (1996–2024) From Turkey

Contact Dermatitis, EarlyView.
The overall prevalence of sensitization to FA/FRs was 1.9% (48/2592). ACD was diagnosed in 37.5% (18/48), comprising non‐occupational ACD (83.3%) and occupational ACD (16.7%). FA 1%–2% aq. failed to detect FR sensitisation in 31.9% (n = 15/47) and FR‐induced ACD in 35.3% (n = 6/17) of patients.
Esen Özkaya, Ömer Mangır, Elizaveta Ayas   +2 more
wiley   +1 more source

Solubility of Tris(hydroxymethyl)aminomethane in Water + 1-Propanol Mixtures at Various Temperatures [PDF]

, 2014
Vahid Jouyban‐Gharamaleki, Karim Jouyban-Gharamaleki, Jafar Soleymani, William E. Acree, Abolghasem Jouyban   +4 more
openalex   +1 more source

Phycocyanobilin biosynthesis in Galdieria sulphuraria requires isomerization of phycoerythrobilin synthesized by bilin reductases

The FEBS Journal, EarlyView.
The biosynthesis of bilins, tetrapyrroles essential for light harvesting and sensing, is performed by specific enzymes (FDBRs). In Galdieria sulphuraria, both phycobiliprotein types bind phycocyanobilin, despite lacking the canonical synthesizing gene PCYA. Instead, PEBA and PEBB are encoded, producing phycoerythrobilin, proposed to be later isomerized
Federica Frascogna, Nathan C. Rockwell, Jana Hartmann, Julie M. Mudler, Nicole Frankenberg‐Dinkel   +4 more
wiley   +1 more source

Anti‐cancer drugs targeting the NADH‐binding site of VDAC rewire channel electrophysiology and partially suppress cation selectivity

The FEBS Journal, EarlyView.
VA molecules alter VDAC1 gating by increasing anion flow and reducing cation permeability. In cancer cells, which rely on ER‐mitochondria Ca2+ transfer and overexpress VDAC1, this imbalance triggers bioenergetic stress, ROS buildup, and mitochondrial collapse, leading to cell death.
Stefano Conti‐Nibali, Giuseppe Battiato, Salvatore Antonio Maria Cubisino, Cristina Arrigoni, Marco Lolicato, Simona Reina, Vito De Pinto   +6 more
wiley   +1 more source

Exploring causal correlations between oily fish intake and multiple sclerosis: A two-sample Mendelian randomization study. [PDF]

Asia Pac J Clin Nutr
Chang S, Shi K, Zhang M.
europepmc   +1 more source

Preparation and Stereochemistry of 12a-Hydroxymethyl Derivatives of Rotenone and Amorphigenin [PDF]

, 1983
Irena Kostova, I. Ognyanov
openalex   +1 more source

Contrasting effects of different molecular crowding environments on base‐pair opening/closing dynamics of DNA triplex structures

The FEBS Journal, EarlyView.
Base‐pair opening and closing regulate nucleic‐acid structure, stability, and function, but how these motions behave under intracellular molecular crowding remains unclear. Using NMR, we quantified these dynamics in a DNA triplex under two crowder‐reconstituted environments that mimic cellular crowding.
Tomoki Sakamoto, Yudai Yamaoki, Takashi Nagata, Masato Katahira   +3 more
wiley   +1 more source

The unexpected reduction of the vinyl group of chlorophyll B by sodium borohydriede in methanolic extracts of maize leaves and its inhibition by 8-hydroxyquinoline [PDF]

, 1993
Cmiel, E., Katheder, Ingrid, Porra, R. J., Scheer, Hugo, Schäfer, W.   +4 more
core   +1 more source

ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis

The FEBS Journal, EarlyView.
The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati, Chandra Sekhar Yadavalli, Md Monirul Hoque, Swapna Thota, Gadiparthi N. Rao   +4 more
wiley   +1 more source