Results 321 to 330 of about 142,060 (347)
Some of the next articles are maybe not open access.
Dynamics of DNA Hydroxymethylation in Zebrafish
Zebrafish, 2015During embryonic development in mammals, most of the methylated cytosines in the paternal genome are converted to 5-hydroxymethyldeoxycytidine (hmC), as part of DNA methylation reprogramming. Recent data also suggest tissue-specific functional roles of hmC, perhaps as an epigenetic mark.
Peter Aleström +3 more
openaire +3 more sources
General Pharmacology: The Vascular System, 1997
1. The N-(hydroxymethyl) melamines are analogs of the antitumor agent hexamethylmelamine (HMM) which do not require bioactivation to exert their antitumor effects. 2. Trimelamol (N2,N4,N6-trihydroxymethyl-N2,N4,N6-trimethylmelamine; TM) was developed as a water-soluble antitumor agent for intravenous administration. 3.
openaire +4 more sources
1. The N-(hydroxymethyl) melamines are analogs of the antitumor agent hexamethylmelamine (HMM) which do not require bioactivation to exert their antitumor effects. 2. Trimelamol (N2,N4,N6-trihydroxymethyl-N2,N4,N6-trimethylmelamine; TM) was developed as a water-soluble antitumor agent for intravenous administration. 3.
openaire +4 more sources
2-(Hydroxymethyl)pyridinium dihydrogenphosphate
Acta Crystallographica Section C Crystal Structure Communications, 2003The title compound, C(6)H(8)NO(+).H(2)PO(4)(-), consists of 2-(hydroxymethyl)pyridinium and dihydrogenphosphate ions. The dihydrogenphosphate moieties are linked into chains by pairs of P-O-H.O-P hydrogen bonds. The 2-(hydroxymethyl)pyridinium cations are connected to the dihydrogenphosphate units by O-H.O and N-H.O hydrogen bonds.
Demir, S +2 more
openaire +4 more sources
ChemInform Abstract: Trialkylsilylmethyltris(hydroxymethyl)methanes.
ChemInform, 1989AbstractAldol condensation of the β‐trialkylsilylpropanals (I) with formaldehyde (II) and subsequent Cannizzaro reaction in the presence of KOH give the title compounds (III) which are transformed into the urethanes (V), the cyanoethyl ether (VII), and the acetate (IX).
A. K. Ustinov +2 more
openaire +3 more sources
ChemInform Abstract: An Efficient Hydroxymethylation of Lactams.
ChemInform, 1995AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Bruno Jouglet +2 more
openaire +3 more sources
Tracking genomic hydroxymethylation by the base
Nature Methods, 2011A method uses single-molecule, real-time DNA sequencing to detect the modified base 5-hydroxymethylcytosine, an epigenetic mark recently suspected of having essential roles in genome regulation.
Salbert, Gilles, Weber, Michael
openaire +2 more sources
Heat of formation of hydroxymethyl [PDF]
The Journal of Physical Chemistry, 1993 Threshold photoionization mass spectrometry has been used to measure the appearance energy for the formation of CH 2 OH + from methanol. A value of 708.5±0.8 kJ-mol -1 is obtained for the 298 K cationic heat of formation, which results in a corresponding heat of formation for the hydroxymethyl radical of -18.9±1.0 kJ mol -1 .
John C. Traeger, John L. Holmes
openaire +1 more source
Hydroxymethylation of pyrimidine mononucleotides with formaldehyde
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1967Abstract The 5-hydroxymethyl derivatives of the 5′-mononucleotides corresponding to uracil and cytosine, both in the ribose and deoxyribose series, have been obtained by the direct coupling of formaldehyde to the pyrimidine ring, catalyzed by base.
Alvaro H. Alegria, Alvaro H. Alegria
openaire +3 more sources
MGMT Hydroxymethylation in glioblastoma
Pathology, 2012O 6 -methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme which is commonly hypermethylated in glioblas-tomas. Methylation of the MGMT promoter is associated with an improved response to alkylating agent chemotherapy and patient survival.
Cheryl C. Y. Li +10 more
openaire +2 more sources
2‐(Hydroxymethyl)androstene Derivatives [PDF]
Liebigs Annalen der Chemie, 1987 Abstract3‐Hydroxy‐2‐hydroxymethyl‐ (2 and 3) and 3‐hydroxymethyl‐3‐oxoandrostenes 4 were prepared from 2‐hydroxymethylene derivatives 1. The configurations of the chiral centers were determined on the basis of chiroptical, spectroscopical, and X‐ray analytical data. Furthermore, elimination reaction products (5, 6) were identified.
Vincze Irén +4 more
openaire +2 more sources