Results 351 to 360 of about 189,846 (385)

MGMT Hydroxymethylation in glioblastoma

Pathology, 2012
O 6 -methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme which is commonly hypermethylated in glioblas-tomas. Methylation of the MGMT promoter is associated with an improved response to alkylating agent chemotherapy and patient survival.
Cheryl C. Y. Li, Cheryl C. Y. Li, Catherine M. Suter, Simon Flanagan, Simon Flanagan, Michael E. Buckland, Michael E. Buckland, Maggie Lee, Maggie Lee, Ruta Gupta, Ruta Gupta   +10 more
openaire   +2 more sources

2‐(Hydroxymethyl)androstene Derivatives [PDF]

Liebigs Annalen der Chemie, 1987
Abstract3‐Hydroxy‐2‐hydroxymethyl‐ (2 and 3) and 3‐hydroxymethyl‐3‐oxoandrostenes 4 were prepared from 2‐hydroxymethylene derivatives 1. The configurations of the chiral centers were determined on the basis of chiroptical, spectroscopical, and X‐ray analytical data. Furthermore, elimination reaction products (5, 6) were identified.
Vincze Irén, Somlai Csaba, Schneider Gyula, Dombi György, Kálmán Alajos   +4 more
openaire   +2 more sources

Hydroxymethylation and cyanoethylation of nitroimidazoles

Journal of Heterocyclic Chemistry, 1979
AbstractA series of nitroimidazoles were subjected to hydroxymethylations under a variety of conditions. Hydroxymethylation of 1‐(2‐hydroxyethyl), 1‐(2‐acetoxyethyl), and 1‐(2‐chloroethyl) substituted 5‐nitroimidazoles with paraformaldehyde in dimethyl sulfoxide yielded the respective 2‐hydroxymethyl analogs (5–7). However, attempts to hydroxymethylate
Raj K. Sehgal, Krishna C. Agrawal
openaire   +2 more sources

9-Glutathionyl-6,7-dihydro-1-hydroxymethyl-5H-pyrrolizine Is the Major Pyrrolic Glutathione Conjugate of Retronecine-Type Pyrrolizidine Alkaloids in Liver Microsomes and in Rats.

Chemical Research in Toxicology, 2016
Retronecine-, otonecine-, and heliotridine-type pyrrolizidine alkaloids (PAs) are all reported to be hepatotoxic. These PAs are suggested to be metabolized to the corresponding electrophilic dehydropyrrolizidine alkaloids (dehydro-PAs) and subsequently ...
Meixia Chen, Liang Li, D. Zhong, S. Shen, Jiang Zheng, Xiaoyan Chen   +5 more
semanticscholar   +1 more source

The conversion of 5-hydroxymethyl furfural (HMF) to maleic anhydride with vanadium-based heterogeneous catalysts

, 2016
Heterogeneous catalytic systems using vanadium-based solid catalysts with or without silica support were developed for the oxidation of 5-hydroxymethyl furfural (HMF) to maleic anhydride (MA) and up to 79% yield of MA was achieved.
Xiukai Li, Yugen Zhang
semanticscholar   +1 more source

Hydroxymethylated DNA Immunoprecipitation (hmeDIP)

2013
5-hydroxymethylcytosine (5hmC) was recently identified as an abundant epigenetic mark in mammals. Subsequent research has implicated 5hmC in normal mammalian development and disease pathogenesis in humans. Many of the techniques commonly used to assay for canonical 5-methylcytosine (5mC) cannot distinguish between 5hmC and 5mC.
Richard R. Meehan, Colm E. Nestor, Colm E. Nestor   +2 more
openaire   +3 more sources

Hydrogenative ring-rearrangement of biomass derived 5-(hydroxymethyl)furfural to 3-(hydroxymethyl)cyclopentanol using combination catalyst systems of Pt/SiO2 and lanthanoid oxides

, 2017
Combination catalyst systems composed of Pt/SiO2 and lanthanoid oxides (Pt/SiO2 + LOx) efficiently catalyze the hydrogenative ring-rearrangement of 5-(hydroxymethyl)furfural (HMF) in water to produce 3-(hydroxymethyl)cyclopentanol (HCPO), which can be a ...
Junya Ohyama, Y. Ohira, A. Satsuma
semanticscholar   +1 more source

High yield 5-(hydroxymethyl)furfural production from biomass sugars under facile reaction conditions: a hybrid enzyme- and chemo-catalytic technology

, 2016
Correction for ‘High yield 5-(hydroxymethyl)furfural production from biomass sugars under facile reaction conditions: a hybrid enzyme- and chemo-catalytic technology’ by Siamak Alipour, Green Chem., 2016, 18, 4990–4998.
Siamak Alipour
semanticscholar   +1 more source

Insights into the interplay of Lewis and Brønsted acid catalysts in glucose and fructose conversion to 5-(hydroxymethyl)furfural and levulinic acid in aqueous media.

Journal of the American Chemical Society, 2013
5-(Hydroxymethyl)furfural (HMF) and levulinic acid production from glucose in a cascade of reactions using a Lewis acid (CrCl3) catalyst together with a Brønsted acid (HCl) catalyst in aqueous media is investigated.
V. Choudhary, S. H. Mushrif, Christopher R. Ho, A. Anderko, V. Nikolakis, N. Marinkovic, A. Frenkel, S. Sandler, D. Vlachos   +8 more
semanticscholar   +1 more source

Heterogeneous zirconia-supported ruthenium catalyst for highly selective hydrogenation of 5-hydroxymethyl-2-furaldehyde to 2,5-bis(hydroxymethyl)furans in various n-alcohol solvents

, 2016
5-Hydroxymethyl-2-furaldehyde (HMF) was hydrogenated to 2,5-bis(hydroxymethyl)furan (BHMF) (>99% yield) in various n-alcohol solvents using a Ru(OH)x/ZrO2 catalyst. The TON and TOF for the hydrogenation were calculated to be 912 and 304 h−1, respectively.
Jusung Han, Yohan Kim, Hyung-seok Jang, S. Hwang, J. Jegal, J. Kim, Yoon-Sik Lee   +6 more
semanticscholar   +1 more source