Results 61 to 70 of about 189,846 (385)

Enzymatic separation of epimeric 4-C-hydroxymethylated furanosugars: Synthesis of bicyclic nucleosides

Beilstein Journal of Organic Chemistry, 2017
Conversion of D-glucose to 4-C-hydroxymethyl-1,2-O-isopropylidene-α-D-ribofuranose, which is a key precursor for the synthesis of different types of bicyclic/spiro nucleosides, led to the formation of an inseparable 1:1 mixture of the desired product and
Neha Rana, Manish Kumar, Vinod Khatri, Jyotirmoy Maity, Ashok K. Prasad   +4 more
doaj   +1 more source

Tissue-Specific Differences in DNA Modifications (5-Hydroxymethylcytosine, 5-Formylcytosine, 5-Carboxylcytosine and 5-Hydroxymethyluracil) and Their Interrelationships.

PLoS ONE, 2015
BackgroundReplication-independent active/enzymatic demethylation may be an important process in the functioning of somatic cells. The most plausible mechanisms of active 5-methylcytosine demethylation, leading to activation of previously silenced genes ...
Daniel Gackowski, Ewelina Zarakowska, Marta Starczak, Martyna Modrzejewska, Ryszard Olinski   +4 more
doaj   +1 more source

A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of β-N-acetylglucosaminidases [PDF]

, 2007
The synthesis of an analogue of 6-epi-valienamine bearing an acetamido group and its characterisation as an inhibitor of β-N-acetylglucosaminidases are described.
Adrian Scaffidi, Backvall, Bailey, Beer, Chen, Chretien, David J. Vocadlo, Davies, Davies, Dennis, Dong, Dorfmueller, Edward J. Taylor, Emsley, Esnouf, Fairweather, Gideon J. Davies, Horsch, Junge, Kappes, Keith A. Stubbs, Knapp, Kraulis, Legler, Lin, Liu, Liu, Macauley, Mark, Money, Murshudov, Namiki, Nicotra, Ogawa, Rana, Rao, Rebecca J. Dennis, Robert V. Stick, Salleh, Scaffidi, Shanmugasundaram, Shitara, Sigurskjold, Stubbs, Stubbs, Svensson, Tanaka, Terinek, Tews, Vocadlo   +49 more
core   +1 more source

Efficient and Selective Electrochemical and Photoelectrochemical Reduction of 5-Hydroxymethylfurfural to 2,5-Bis(hydroxymethyl)furan using Water as the Hydrogen Source

, 2016
Reductive biomass conversion has been conventionally conducted using H2 gas under high-temperature and -pressure conditions. In this study, efficient electrochemical reduction of 5-hydroxymethylfurfural (HMF), a key intermediate for biomass conversion ...
J. Roylance, Tae Woo Kim, Kyoung-Shin Choi   +2 more
semanticscholar   +1 more source

DNA methylation/hydroxymethylation in melanoma

Oncotarget, 2017
Melanoma is a malignant tumor of melanocytes and is considered to be the most aggressive cancer among all skin diseases. The pathogenesis of melanoma has not been well documented, which may restrict the research and development of biomarkers and therapies.
Fu, Siqi, Wu, Haijing, Zhang, Huiming, Lu, Qianjin, Lian, Christine   +4 more
openaire   +4 more sources

Covalent Binding of Dexamethasone to Polyimide Improves Biocompatibility of Neural Implantable Devices

Advanced Healthcare Materials, EarlyView.
The covalent binding of dexamethasone to the surface of polyimide represents the electrically inert part of implantable intraneural devices. This ensures a sustained release of the drug for 9 weeks. In vitro and in vivo tests confirm the reduction of the foreign body reactions and the improved biocompatibility of dexamethasone functionalized polyimide.
Giulia Turrin, Jose Crugeiras, Chiara Bisquoli, Davide Barboni, Martina Catani, Bruno Rodríguez‐Meana, Rita Boaretto, Michele Albicini, Stefano Caramori, Claudio Trapella, Thomas Stieglitz, Yara Baslan, Hanna Karlsson‐Fernberg, Fernanda L. Narvaez‐Chicaiza, Edoardo Marchini, Alberto Cavazzini, Ruben López‐Vales, Maria Asplund, Xavier Navarro, Stefano Carli   +19 more
wiley   +1 more source

Inhibition of sterol biosynthesis in animal cells by 14 alpha-hydroxymethyl sterols.

Journal of Lipid Research, 1980
The chemical syntheses of a number of 14 alpha-hydroxymethyl sterols and 14 alpha -hydroxymethyl-15 alpha-hydroxysterols and their derivatives have been pursued to permit evaluation of their activity in the inhibition of sterol biosynthesis in animal ...
G J Schroepfer, Jr, E J Parish, R A Pascal, Jr, A A Kandutsch   +3 more
doaj  

Tris(hydroxymethyl)methanaminium trifluoroacetate

Acta Crystallographica Section E, 2012
In the crystal structure of the title salt, C4H12NO3+·C2F3O2−, N—H...O and O—H...O hydrogen bonds link the ions, forming a complex three-dimensional network.
Ming-Liang Liu
doaj   +1 more source

New ferrocene-derived hydroxymethylphosphines: FcP(CH₂OH)₂ [Fc=(η⁵-C₅H₅)Fe(η⁵-C₅H₄)] and the dppf analogue 1,1′-Fc′[P(CH₂OH)₂]₂ [Fc′=Fe(η⁵-C₅H₄)₂] [PDF]

, 2001
Reactions of the ferrocene-phosphines FcPH₂ and 1,1′-Fc′(PH₂)₂ with excess formaldehyde gives the new hydroxymethylphosphines FcP(CH₂OH)₂ 1 and 1,1′-Fc′[P(CH₂OH)₂]₂ 2, respectively. Phosphine 1 is an air-stable crystalline solid, whereas 2 is isolated as
Alley, Steven R., Henderson, William
core   +2 more sources

Investigation on the Influence of Protein Corona and Platelet Adhesion on Storage Bag Surface on the Platelet Storage Lesion

Advanced Healthcare Materials, EarlyView.
Platelet quality deteriorates during storage due to protein and platelet adhesion to current bag materials. Here, polymer coatings are identified that reduce adhesion and translated them to mini‐storage bags. Platelet quality are not impacted, despite significantly reducing adhesion.
Nicolas Pereyra, Kai Yu, Jason Rogalski, Taylor Olivia Da Silva, Parisa Golesorkhi, Madeleine Goldstein, Dana V. Devine, Jayachandran N. Kizhakkedathu   +7 more
wiley   +1 more source