Isolation and Characterization of a Rhodobacter Capsulatus hemC Mutant. [PDF]
Rhodobacter capsulatus, a purple, nonsulfur photosynthetic bacterium, uses the tetrapyrrole pathway to synthesize four end products: heme, bacteriochlorophyll, vitamin B12, and siroheme. This laboratory has focused on the regulation of the common pathway
Sullivan, Karen Coleman
core +2 more sources
European mtDNA Variants Are Associated With Differential Responses to Cisplatin, an Anticancer Drug: Implications for Drug Resistance and Side Effects. [PDF]
Background: Cisplatin, a powerful antitumor agent, causes formation of DNA adducts, and activation of apoptotic pathways. Presently, cisplatin resistance develops in up to 70% of patients but the underlying molecular mechanism(s) are unclear and there ...
Abedi, Sina +13 more
core +1 more source
Investigating the critical genes related to milk synthesis is essential for the improvement of the milk yield of the yak. Real-time quantitative polymerase chain reaction (RT-qPCR) is a reliable and widely used method to measure and evaluate gene ...
Xiaoyun Wu +9 more
doaj +1 more source
Peroxisome proliferator-activated receptor γ agonism attenuates endotoxaemia-induced muscle protein loss and lactate accumulation in rats [PDF]
The peroxisome proliferator-activated receptor γ (PPARγ) agonist rosiglitazone (Rosi) appears to provide protection against organ dysfunction during endotoxaemia.
Alamdari +49 more
core +2 more sources
Uneven distribution of cobamide biosynthesis and dependence in bacteria predicted by comparative genomics. [PDF]
The vitamin B12 family of cofactors known as cobamides are essential for a variety of microbial metabolisms. We used comparative genomics of 11,000 bacterial species to analyze the extent and distribution of cobamide production and use across bacteria ...
Haft, David R +6 more
core +1 more source
Meatal Swabs Contain Less Cellular Material and Are Associated with a Decrease in Gram Stain Smear Quality Compared to Urethral Swabs in Men [PDF]
Urethral swabs are the samples of choice for point-of-care Gram stain testing to diagnose Neisseria gonorrhoeae infection and nongonococcal urethritis (NGU) in men.
Aaron, Kristal J. +4 more
core +1 more source
Characterisation, genomic organisation, expression and function of the mEphA1 receptor Tyrosine Kinase [PDF]
The Eph receptor tyrosine kinases and their ephrin ligands are cell surface molecules with a wide range of biological functions. Specifically, the Eph/ephrin receptor-ligand family influences cell behaviour during both embryogenesis and adult life ...
Coulthard, Mark G.
core
Critical evaluation of HPV16 gene copy number quantification by SYBR green PCR
Background Human papilloma virus (HPV) load and physical status are considered useful parameters for clinical evaluation of cervical squamous cell neoplasia. However, the errors implicit in HPV gene quantification by PCR are not well documented.
Pett Mark R +7 more
doaj +1 more source
Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama +4 more
core +1 more source
Selection of suitable housekeeping genes for expression analysis in glioblastoma using quantitative RT-PCR [PDF]
Background: Considering the broad variation in the expression of housekeeping genes among tissues and experimental situations, studies using quantitative RT-PCR require strict definition of adequate endogenous controls.
Carlotti, Carlos G. +8 more
core +3 more sources

