Randomized controlled trial comparing the efficacy of daily and every other day atorvastatin therapy and its correlation with serum hydroxymethylglutaryl-CoA reductase enzyme levels in naïve dyslipidemic patients [PDF]
Indian Heart Journal, 2018 Objective: Data regarding efficacy comparison of daily regimen (DR) versus every other day regimen (EODR) atorvastatin therapy is not validated by estimation of serum hydroxymethylglutaryl-CoA reductase (HMGCR) levels and HMGCR correlation with lipid ...
Manoj Kumar +4 more
doaj +2 more sources
Regulation of hydroxymethylglutaryl-CoA reductase in rat leukocytes
Journal of Lipid Research, 1977 Methods were developed for the assay of hydroxymethylglutaryl-CoA reductase (NADPH) activity in microsomes from rat leukocytes. The activity in freshly isolated leukocytes is low compared to rat liver but can be assayed reliably. The patterns of response
N L Young, V W Rodwell
doaj +3 more sources
The Biochemical Basis of Hydroxymethylglutaryl-CoA Reductase Inhibitors as Neuroprotective Agents in Aneurysmal Subarachnoid Hemorrhage [PDF]
Pharmaceuticals, 2010 Aneurysmal subarachnoid hemorrhage (SAH) has the highest morbidity and mortality rates of all types of stroke. Many aneurysmal SAH patients continue to suffer from significant neurological morbidity and mortality directly related to delayed cerebral ...
George Kwok Chu Wong, Wai Sang Poon
doaj +2 more sources
Production of borneol, camphor, and bornyl acetate using engineered Saccharomyces cerevisiae [PDF]
Metabolic Engineering CommunicationsMicrobial production of bicyclic monoterpenes is of great interest because their production primarily utilizes non-sustainable resources. Here, we report an engineered Saccharomyces cerevisiae yeast that produces bicyclic monoterpenes, including borneol,
Masahiro Tominaga +5 more
doaj +2 more sources
Integrated transcriptomic and metabolomic analysis reveal the mechanism of citral production in Camphora officinarum Nees ex Wall leaves [PDF]
Frontiers in Plant ScienceCamphora officinarum Nees ex Wall (C. officinarum), a citral-rich aromatic plant, is recognized as an unrivalled natural source of citral for spice production.
Qingyan Ling +7 more
doaj +2 more sources
Role of Blood Lipid Levels and Lipid-Lowering Therapy in Stroke Patients with Different Levels of Cerebral Artery Diseases: Reconsidering Recent Stroke Guidelines [PDF]
Journal of Stroke, 2021 Hyperlipidemia is an important risk factor for ischemic stroke; the Stroke Prevention by Aggressive Reduction in Cholesterol Level and Treat Stroke to Target studies have shown that statins are beneficial for patients with stroke and that a low target ...
Jong S. Kim
doaj +1 more source
Early efficacy and safety of statin therapy in Korean patients with hypercholesterolemia: Daegu and Gyeongbuk Statin Registry [PDF]
The Korean Journal of Internal Medicine, 2020 Background/Aims To date, prospective data are limited on efficacy and safety profiles of statin therapy in Korean hypercholesterolemic patients. Hence, the aim of this study was to evaluate the practice patterns of statin therapy and its efficacy and ...
Han Joon Bae +11 more
doaj +1 more source
A hydroxymethylglutaryl-CoA reductase inhibitor synthesized by yeasts [PDF]
FEMS Microbiology Letters, 1995 Screening of different yeast species showed that they are able to synthesize hydroxymethylglutaryl-CoA (HMGCoA) reductase inhibitors. Crude methanol extracts and the purified inhibitors from Pichia labacensis and Candida cariosilignicola were tested for their biological activity on the solubilized microsomal HMGCoA reductase from Chinese hamster ovary ...
N, Gunde-Cimerman +2 more
openaire +4 more sources
Beneficial Effects of Statins on Seizures Independent of Their Lipid-Lowering Effect: A Narrative Review [PDF]
Iranian Journal of Medical Sciences, 2023 Among the many types of central nervous system (CNS) disorders, seizures and epilepsy severely affect the quality of life and routine daily activity of the sufferers.
Arash Amanlou +4 more
doaj +1 more source
Should all patients with psoriasis receive statins? Analysis according to different strategies, [PDF]
Anais Brasileiros de Dermatologia, 2020 Background: Different strategies have been proposed for the cardiovascular risk management of patients with psoriasis. Objective: To estimate the cardiovascular risk and evaluate two cardiovascular prevention strategies in patients with psoriasis ...
Walter Masson +3 more
doaj +1 more source