Statins induce lethal effects in acute myeloblastic lymphoma cells within 72 hours [PDF]
, 2007 HMG-CoA Reductase inhibitors (statins) induce apoptosis in acute myeloid leukemia (AML) cells in vitro; however, the concentrations associated with cell death in AML cells are higher than those clinically tolerated during prolonged therapy.
Burke, Lillian P., Kukoly, Cynthia A.
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The FASEB Journal, Volume 39, Issue 17, 15 September 2025.Schematic representation of how gut microbiota‐derived metabolites—such as SCFAs, TMAO, and tryptophan derivatives—modulate cardiac energy metabolism, inflammation, and epigenetic regulation, contributing to the pathogenesis of diabetic cardiomyopathy. Therapeutic strategies targeting the gut–heart axis hold translational promise for metabolic cardiac ...
Jing‐yu Jin +12 more
wiley +1 more source
Evaluating an implementation strategy in cardiovascular prevention to improve prescribing of statins in Germany: an intention to treat analysis [PDF]
, 2013 BACKGROUND: The prescription of statins is an evidence-based treatment to reduce the risk of cardiovascular events in patients with elevated cardiovascular risk or with a cardiovascular disorder (CVD).
Baum, Erika +7 more
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Comprehensive Reviews in Food Science and Food Safety, Volume 24, Issue 5, September 2025.ABSTRACT Pleurotus mushrooms are fungi widely consumed due to their high nutritional value and potential applications as nutraceuticals. Their sustainable cultivation and rich composition of bioactive compounds provide significant health benefits. This review examines the scientific evidence regarding the safety, efficacy, and nutraceutical potential ...
Patrícia Lima Araújo +7 more
wiley +1 more source
Lipid-lowering drugs (statins) and peripheral neuropathy
Electronic Physician, 2018 Background and aim: Peripheral neuropathy is a disorder with often unknown causes. Some drugs, including statins, are proposed to be among the causes of peripheral neuropathy.
Mohammadreza Emad +3 more
doaj +1 more source
Spielen Statine eine Rolle als adjuvante Therapie bei Entzündung? / Do statins play a role as an adjuvant therapy in inflammation? [PDF]
, 2010 Despite recent advances in management of patients in intensive care units, sepsis and septic shock are the major causes of morbidity and mortality. Prompt and adequate antibiotic therapy accompanied by surgical removal of the infectious material are the ...
Almog +83 more
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BMC Gastroenterology, 2012 Background The aetiology of colorectal cancer (CRC) remains elusive in the majority of cases. There is experimental evidence to show that HMG-CoA reductase inhibitors (statins) may inhibit proliferation and induce cause apoptosis in CRC cells and ...
Broughton Thomas +2 more
doaj +1 more source
AMPK:a cellular energy sensor primarily regulated by AMP [PDF]
, 2014 AMPK (AMP-activated protein kinase) is a cellular energy sensor that monitors the ratio of AMP/ATP, and possibly also ADP/ATP, inside cells. Once activated by falling cellular energy levels, it acts to restore energy homoeostasis by switching on ...
Gowans, Graeme J., Hardie, D. Grahame
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Improvement of clinical outcomes in patients undergoing peritoneal dialysis using hydroxymethylglutaryl-CoA reductase inhibitors: A systematic review and meta-analysis. [PDF]
J Chin Med Assoc, 2023 Lee DY +5 more
europepmc +1 more source
Accessing the genomic information of unculturable oceanic picoeukaryotes by combining multiple single cells [PDF]
, 2017 Mangot, Jean-François et al.-- 12 pages, 7 figures, 2 tables, supplementary information https://dx.doi.org/10.1038/srep41498Pico-sized eukaryotes play key roles in the functioning of marine ecosystems, but we still have a limited knowledge on their ...
Latorre, Fran +4 more
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