Results 111 to 120 of about 16,480 (226)

Isoprenoid biosynthesis in the erythrocytic stages of Plasmodium falciparum [PDF]

, 2011
The development of new drugs is one strategy for malaria control. Biochemical pathways localised in the apicoplast of the parasite, such as the synthesis of isoprenic precursors, are excellent targets because they are different or absent in the human ...
JORDÃO, Fabiana Morandi, KATZIN, Alejandro Miguel, KIMURA, Emília Akemi   +2 more
core   +3 more sources

Regulation of human leukocyte microsomal hydroxymethylglutaryl-CoA reductase activity by a phosphorylation and dephosphorylation mechanism

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1984
The activity of microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase (EC 1.1.1.34), obtained from cultured human IM-9 lymphoid cells or freshly isolated human peripheral blood leukocytes, is modulated by a phosphorylation/dephosphorylation mechanism.
Division of Endocrinology and Metabolism, University of Florida, College of Medicine, Gainesville, FL 32610 U.S.A. ( host institution ), Harwood, H.James ( author ), Schneider, Marita ( author ), Stacpoole, Peter W. ( author )   +3 more
openaire   +3 more sources

Antimicrobial Potential of Hydroxymethylglutaryl-Coa Reductases Inhibitors

The 1st International Electronic Conference on Clinical Medicine, 2021
Hélida Maravilha Dantas e Sousa Almeida, Igor de Sousa Oliveira, Sávio Benvindo Ferreira   +2 more
openaire   +1 more source

Short-Term Therapy with High Dose Atorvastatin in Patients with Coronary Artery Disease Can Reduce Inflammatory Process [PDF]

Acta Medica Iranica, 2010
Coronary heart disease is the leading cause of death and disability in adults. The association between acute coronary syndrom (ACS) and elevated serum high sensitivity c-reactive protein (hsCRP) suggests that chronic inflammation of the coronary arterial
Vida Nesar Hossein, Keivan Yosef Nejad, Fatemeh Abdollahian   +2 more
doaj   +1 more source

The Effect of Statins on Mortality in Septic Patients: a Meta-Analysis of Randomized Controlled Trials [PDF]

, 2013
OBJECTIVE: Statins are among the most prescribed drugs worldwide and their recently discovered anti-inflammatory effect seems to have an important role in inhibiting proinflammatory cytokine production, chemokines expression and counteracting the harmful
Belletti, A, Cabrini, L, Carozzo, A, Castro, ML, Chiesa, R, Feltracco, P, Finco, G, Landoni, G, Pasin, L, Zangrillo, A   +9 more
core  

Transcriptome analysis reveals in vitro cultured Withania somnifera leaf and root tissues as a promising source for targeted withanolide biosynthesis [PDF]

, 2015
Arul Nagappan, Gon Kim, Irene Mariam Roy, Kalaiselvi Rajasekaran, Kalaiselvi Senthil, Murukarthick Jayakodi, Pankajavalli Thirugnanasambantham, Pradeepa Duraisamy, Preethi M Purushotham, Sang Lee, Senthil Natesan, Shobana Nancy Charles, Tae Yang, Tae-Sun Min, Yun Lee   +14 more
core   +1 more source

Inhibition of yeast hydroxymethylglutaryl‐CoA reductase by a rat liver mitochondrial preparation [PDF]

FEBS Letters, 1974
Madhosingh, C., Migicovsky, B.B., Wood, I.M.   +2 more
openaire   +2 more sources

Simvastatin pre-treatment improves survival and mitochondrial function in a 3-day fluid-resuscitated rat model of sepsis [PDF]

, 2017
Statins may offer protective effects in sepsis through anti-inflammatory, mitochondrial protection and other actions. We thus evaluated the effects of simvastatin on survival, organ and mitochondrial function, tissue and plasma ubiquinone levels and ...
Backman, JT, Bauer, M, Bläss, M, Brealey, D, Hargreaves, I, Lindig, S, McAuley, DF, Morel, J, Neergheen, V, Singer, M   +9 more
core  

Regulation of Macrophage Cholesterol Efflux through Hydroxymethylglutaryl-CoA Reductase Inhibition [PDF]

Journal of Biological Chemistry, 2005
Carmen A. Argmann, Jane Y. Edwards, Cynthia G. Sawyez, Caroline H. O'Neil, Robert A. Hegele, J. Geoffrey Pickering, Murray W. Huff   +6 more
openaire   +1 more source

The discovery of PCSK9 inhibitors: A tale of creativity and multifaceted translational research. [PDF]

, 2013
Elguindy, A, Yacoub, MH
core   +1 more source